Results 121 to 130 of about 2,744,821 (349)

Analysis of MicroRNA Expression in Embryonic Developmental Toxicity Induced by MC-RR

, 2011
As cynobacterial blooms frequently occur in fresh waters throughout the world, microcystins (MCs) have caused serious damage to both wildlife and human health.
xieping@ihb.ac.cn, Zhao, Yanyan, Xiong, Qian, Zhao, YY (reprint author), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosys, Wuhan, Peoples R China, Xie, Ping   +4 more
core  

Gold Nanoparticles Reduce Food Sensation in Caenorhabditis elegans via the Voltage-Gated Channel EGL-19 [Corrigendum]

International Journal of Nanomedicine, 2023
Wang M, Zhang Z, Sun N, et al. Int J Nanomedicine. 2023;18:1659—1676. The authors have advised the affiliation list on page 1659 is incorrect. The correct author list and affiliation is as follows.
Wang M, Zhang Z, Sun N, Yang B, Mo J, Wang D, Su M, Hu J, Wang M, Wang L   +9 more
doaj  

Safety assessment of cerium oxide nanoparticles: combined repeated-dose toxicity with reproductive/developmental toxicity screening and biodistribution in rats

Nanotoxicology, 2019
Cerium oxide nanoparticles (CeO2 NPs) are widely used in various commercial applications because of their characteristic properties. People can be easily exposed to CeO2 NPs in real life, but the safety assessment of CeO2 NPs has not been fully ...
Jinsoo Lee, J. Jeong, Sang Yun Kim, Seung-Jin Lee, Young-Jun Shin, W. Im, Sung‐Hwan Kim, Kwangsik Park, E. Jeong, S. Nam, Wook-Joon Yu   +10 more
semanticscholar   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Ritonavir Has Reproductive Toxicity Depending on Disrupting PI3K/PDK1/AKT Signaling Pathway

Ritonavir (RTV) is an antiviral and a component of COVID-19 treatments. Moreover, RTV demonstrates anti-cancer effects by suppressing AKT. However, RTV has cytotoxicity and suppresses sperm functions by altering AKT activity.
Eun-Ju Jung, Jae-Hwan Jo, Claudine Uwamahoro, Seung-Ik Jang, Woo-Sung Kwon, Woo-Jin Lee, Ju-Mi Hwang, Jeong-Won Bae   +7 more
core   +1 more source

Best practices for developmental toxicity assessment for classification and labeling. [PDF]

, 2018
Many chemicals are going through a hazard-based classification and labeling process in Europe. Because of the significant public health implications, the best science must be applied in assessing developmental toxicity data.
dIRAS RA-1, Connie Chen, Isabelle Leconte, Foreman, Jennifer, Manon Beekhuijzen, Nina Hallmark, Hallmark, Nina, Chen, Connie, Piersma, Aldert, Sub RIVM, Attias, Leonello, Daston, George, Leonello Attias, Leconte, Isabelle, George Daston, Aldert Piersma, Jennifer Foreman, Beekhuijzen, Manon   +17 more
core   +1 more source

Expression classifiers for developmental toxicants

EXCLI journal, 2015
EXCLI Journal; 14:Doc1291; ISSN 1611 ...
openaire   +3 more sources

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

The Aryl Hydrocarbon Receptor Mediates the Neurodevelopmental Toxicity of Perfluorooctane Sulfonamide in Zebrafish Larvae

Perfluorooctane sulfonamide (PFOSA), the direct precursor to perfluorooctane sulfonate (PFOS), is widely present in the environment. Research has indicated that PFOSA is cardiotoxic and hepatotoxic, but its impact on neurodevelopment remains unclear.
Tao Chen, Yan Jiang, Jie Zhang, Pinyi Chen, Kang Wang   +4 more
core   +1 more source