Results 131 to 140 of about 2,744,821 (349)

In vitro Morphogenesis in Developmental Toxicity Testing: Assay Validation and the Search for Teratogenic Mechanisms [PDF]

, 2018
Teratogens are chemicals that can cause birth defects in the developing embryo during pregnancy. Major structural birth defects affect 2-5% of children, but the etiology of this developmental error is often unknown. Exposure to teratogens (chemicals that
Warkus, Erica L. L.
core  

Dictyostelium discoideum: An Alternative Nonanimal Model for Developmental Toxicity Testing [PDF]

, 2021
A critical aspect of toxicity evaluation is developmental and reproductive toxicity (DART) testing. Traditionally, DART testing has been conducted in vivo in mammalian model systems.
Thompson, CRL, Baines, RP, Wolton, K
core  

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Developmental toxicity of engineered nanomaterials

, 2016
Study of air pollution indicates that minute particles may adversely interfere with pregnancy and fetal development. As engineering of nanoparticles have emerged, so has concern that these might interfere with reproductive and developmental functions ...
Pesch, Sandra Goericke, Halappanavar, Sabina, Yauk, Carole, Hansen, Jitka S., Vogel, Ulla, Kyjovska, Zdenka O., Jensen, Keld A., Hougaard, Karin S., Jackson, Petra, Wallin, Hakan, Skovmand, Astrid, Boisen, Anne Mette Z.   +11 more
core   +1 more source

Progress in the study of reproductive toxicity of platinum-based antitumor drugs and their means of prevention

Frontiers in Pharmacology
Platinum-based antitumor drugs are broad-spectrum agents with unique mechanisms of action. Combination chemotherapy regimens based on platinum drugs are commonly used in cancer treatment.
Zhan Jin, Liu Zhao-Xia, Peng Fan-Ke, Zhang Wen-Juan, Wei Min-Li, Zeng Han-Yi, Zeng Han-Yi   +6 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

PregPred: an In-Silico Alternative to Animal Testing for Predicting Developmental Toxicity Potential

Background: Understanding potential prenatal and development toxicity hazard associated with the use of pharmaceutical and cosmetic products is an important component of women health.
Alexander, Tropsha, Holli-Joi, Martin, Helena, Hogberg-Durdock, James, Wellnitz, Eugene, Muratov, Ricardo, Tieghi, Nicole, Kleinstreuer, Marielle, Rath, Jose, Moreira-Filho, Kathleen, Gates   +9 more
core   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source