Results 251 to 260 of about 275,688 (307)

Machine learning-based analysis of microfluidic device immobilized C. elegans for automated developmental toxicity testing. [PDF]

Sci Rep
DuPlissis A, Medewar A, Hegarty E, Laing A, Shen A, Gomez S, Mondal S, Ben-Yakar A.   +7 more
europepmc   +1 more source

Probiotics Alleviate Microcystin-LR-Induced Developmental Toxicity in Zebrafish Larvae. [PDF]

Toxics
Wu Q, Gong A, Liu X, Hou J, Liu H, Yang Z, Zhu Y.   +6 more
europepmc   +1 more source

Pluripotent stem cells for target organ developmental toxicity testing. [PDF]

Toxicol Sci
Wu X, Chen Y, Kreutz A, Silver B, Tokar EJ.   +4 more
europepmc   +1 more source

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Developmental Toxicity Prediction

2012
Developmental toxicity may be estimated using commercial and noncommercial software that is already available in the market and/or literature, or models may be built from scratch using both commercial and noncommercial software packages. In this chapter, commonly available software programs that can predict the developmental toxicity of chemicals are ...
Raghuraman, Venkatapathy, Nina Ching Y, Wang   +1 more
openaire   +2 more sources

Developmental Toxicants Risk Assessment

Pediatrics, 1992
To The Editor.— Because of their physical vulnerability and diminutive stature, infants and children often are assumed by the general public and by some health professionals to be more susceptible to the potential toxic effects of the chemicals found in the environment.
P S, Guzelian, C J, Henry, W H, Farland, S S, Olin   +3 more
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Developmental toxicity of pyrethroids

Archives of Toxicology, 2003
A series of studies by Eriksson (1997) has shown persisting changes in neurochemistry and behaviour of mice after administration of very low doses of a range of pesticides to the neonate. Since these studies had all been made in one laboratory and the effects were seen at dose levels which are otherwise without effect, we set out (funded by the ...
Bala Y, Muhammad, Richard D, Verschoyle, David D, Ray   +2 more
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Developmental aspects of neurobehavioural toxicity

Toxicology Letters, 1992
Previous work on the developmental aspects of neurobehavioural toxicity in rats and mice has shown the reliability of a variety of procedures aimed at assessing changes that may have widespread functional consequences, for example: (i) modified Fox batteries to study the maturation of various reflexes and responses after birth, (ii) activity ...
BIGNAMI G, LAVIOLA G, ALLEVA E, CAGIANO R, LACOMBA C, CUOMO, VINCENZO   +5 more
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Developmental Toxicity Study of Dimethylpiperidone

Drug and Chemical Toxicology, 2004
The potential maternal and developmental toxicity of dimethylpiperidone (DMPD) was assessed in rats. Groups of 25 mated female Crl:CD (SD)IGS BR rats were exposed by inhalation (whole-body exposures) for approximately six hours per day over days 7-21 of gestation (G); day 1G was the day of copulation plug detection. The exposure levels were 0, 52, 260,
Susan M, Munley, Arthur J, O'Neill, Deborah L, Tyler, Mark E, Hurtt, Gerald L, Kennedy   +4 more
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Human developmental toxicity and mutagenesis

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1998
A previously described SAR model of human developmental toxicity was analyzed further. The model shows a number of mechanistic similarities with SAR models of other toxicological phenomena (systemic toxicity, chromosomal and genomic effects). This implies that there are many targets associated with developmental effects.
H S, Rosenkranz, Y P, Zhang, O T, Macina, D R, Mattison, G, Klopman   +4 more
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Developmental Toxicity Guidelines Critique

JAPCA, 1987
The toxicity guidelines include the following major sections: definitions and terminology; qualitative assessment which provides a brief description of the most commonly used developmental toxicity experimental protocol; endpoint assays; functional effects; short term testing; pharmacokinetics; studies of humans; structure-activity relationships ...
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