Results 231 to 240 of about 130,891 (267)

Developmental Exposure to Environmental Toxicants

Pediatric Clinics of North America, 2015
Children interact with the physical environment differently than adults, and are uniquely susceptible to environmental toxicants. Routes of absorption, distribution, metabolism, and target organ toxicities vary as children grow and develop. This article summarizes the sources of exposure and known adverse effects of toxicants that are ubiquitous in our
Alison J, Falck, Sandra, Mooney, Shiv S, Kapoor, Kimberly M R, White, Cynthia, Bearer, Dina, El Metwally   +5 more
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Developmental toxicity screening in zebrafish

Birth Defects Research Part C: Embryo Today: Reviews, 2011
Given the ever-increasing toxic exposure ubiquitously present in our environment as well as emerging evidence that these exposures are hazardous to human health, the current rodent-based regulations are proving inadequate. In the process of overhauling risk assessment methodology, a nonrodent test organism, the zebrafish, is emerging as tractable for ...
Catherine W, McCollum, Nicole A, Ducharme, Maria, Bondesson, Jan-Ake, Gustafsson   +3 more
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Developmental toxicity of dichloroacetate in the rat

Teratology, 1992
AbstractDichloroacetic acid (DCA) is a principal by‐product of the chlorine disinfection of water containing humic and fulvic acids, and is also a drug of interest in the therapeutic management of metabolic disorders. The developmental effects of DCA were evaluated in the pregnant Long‐Evans rat.
M K, Smith, J L, Randall, E J, Read, J A, Stober   +3 more
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Developmental Toxicity of Urethan

Toxicology and Industrial Health, 1985
T F, Collins, R E, Sotomayor
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NSAIDs and developmental toxicity

Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2003
Melissa S, Tassinari, Jon C, Cook, Mark E, Hurtt   +2 more
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Maternal factors in developmental toxicity

Teratogenesis, Carcinogenesis, and Mutagenesis, 1987
AbstractThe maternal organism provides the developing embryo with its physical environment, nutrients, and a mechanism for eliminating metabolic wastes. Since the physiological state of the pregnant female affects her ability to provide those requirements for the developing embryo, it is not surprising that there are maternal factors that can affect ...
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Developmental Toxicity Guidelines Critique

JAPCA, 1987
The toxicity guidelines include the following major sections: definitions and terminology; qualitative assessment which provides a brief description of the most commonly used developmental toxicity experimental protocol; endpoint assays; functional effects; short term testing; pharmacokinetics; studies of humans; structure-activity relationships ...
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The Developmental Toxicity Testing of Biologics

2012
The characteristics of biologic drugs, as compared with small molecules, confer significant advantages for both the drug developer and the prospective patients. The necessity for, and the timing of, developmental toxicity testing in the preclinical program must be considered.
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Radiation therapy-associated toxicity: Etiology, management, and prevention

Ca-A Cancer Journal for Clinicians, 2021
Kyle Wang, Joel E Tepper
exaly  

Navigating financial toxicity in patients with cancer: A multidisciplinary management approach

Ca-A Cancer Journal for Clinicians, 2022
Maria Pisu, Grace L Smith, Matthew P Banegas   +2 more
exaly