Results 221 to 230 of about 130,891 (267)

Human developmental toxicity and mutagenesis

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1998
A previously described SAR model of human developmental toxicity was analyzed further. The model shows a number of mechanistic similarities with SAR models of other toxicological phenomena (systemic toxicity, chromosomal and genomic effects). This implies that there are many targets associated with developmental effects.
H S, Rosenkranz, Y P, Zhang, O T, Macina, D R, Mattison, G, Klopman   +4 more
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Developmental toxicity of cesium in the mouse

General Pharmacology: The Vascular System, 1994
1. Maternal intake of 1 mEq CsCl in drinking water at conception until weaning the offspring mice resulted in certain maternal mediated neonatal and developmental toxicity. 2. Initial reduction in body and brain weights were determined in male offspring due to maternal exposure to Cs salt before they attained the control levels. 3.
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Developmental Toxicity of Methoxyflurane in Mice

Anesthesia & Analgesia, 1980
The developmental toxicity of trace, subanesthetic, and anesthetic exposure to methoxyflurane was examined in Swiss/ICR mice. No adverse effects on reproduction or fetal development were demonstrated following exposure to trace (2 ppm) and subanesthetic (60 ppm) concentrations of methoxyflurane for 4 hours daily on days 6 through 15 of pregnancy ...
R S, Wharton, T S, Sievenpiper, R I, Mazze   +2 more
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Developmental toxicity of chlorpropham in mice

Reproductive Toxicology, 1997
The present studies were designed to evaluate the developmental toxicity of chlorpropham in mice. The first study was conducted to determine administration time, and the second study was designed to evaluate dose-response effects. Chlorpropham was administered to pregnant mice by gavage on Days 8, 8.3, 9, 9.3, 10, and 11 of gestation at a level of 3000
T, Tanaka, T, Fujitani, O, Takahashi, S, Oishi, M, Yoneyama   +4 more
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Developmental toxicity of cobalt in the rat

Journal of Toxicology and Environmental Health, 1988
To determine the potential developmental toxicity of cobalt, pregnant Sprague-Dawley rats were given by gavage a daily dose of 0, 25, 50; and 100 mg/kg cobalt(II) chloride on d 6-15 of gestation. Females were sacrificed on d 20. Maternal effects included significant reductions in weight gain and food consumption, particularly at 100 mk/kg.d. Hematocrit,
J L, Paternain, J L, Domingo, J, Corbella   +2 more
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Developmental Toxicity Testing of Vaccines

2012
Preventative and therapeutic vaccines are increasingly used during pregnancy and present special considerations for developmental toxicity testing. The various components of the vaccine formulation (i.e., protein or polysaccharide antigen, adjuvants, and excipients) need to be assessed for direct effects on the developing conceptus.
Paul C, Barrow, Linda, Allais
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Developmental toxicity of valproic acid

Life Sciences, 1991
Valproic acid is a very effective anticonvulsant agent widely used in the management of various forms of epilepsy. Administration of the drug during pregnancy results in increased incidence of congenital abnormalities in both humans and experimental animals.
D, Cotariu, J L, Zaidman
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The developmental toxicity of uranium in mice

Toxicology, 1989
To evaluate the developmental toxicity of uranium, 5 groups of 20 pregnant Swiss mice were given by gavage daily doses of 0, 5, 10, 25 and 50 mg/kg of uranyl acetate dihydrate on gestational days 6-15. Cesarean sections were performed on all females on gestation day 18. Fetuses were examined for external, visceral, and skeletal abnormalities.
J L, Domingo, J L, Paternain, J M, Llobet, J, Corbella   +3 more
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Developmental toxicity of diacetoxyscirpenol in the mouse

Toxicology, 1987
Mycotoxins (frequently referred to as secondary metabolites of toxigenic fungi) are commonly found in foodstuffs and are important because of their association with disease. The mycotoxin diacetoxyscirpenol, or 3-hydroxy-4,15-diacetoxy-12,13-epoxytrichothec-9-ene (DAS), is produced by numerous species of Fusarium and is reportedly toxic to humans and ...
K, Mayura, E E, Smith, B A, Clement, R B, Harvey, L F, Kubena, T D, Phillips   +5 more
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Developmental Toxicity — Magnitude of the Problem

1994
Human reproduction is a complex process, and can be disturbed in many phases by host as well as environmental factors. It has therefore been difficult to distinguish environmental causes of abnormal development from other factors related to the parents’ innate properties.
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