Results 261 to 270 of about 275,688 (307)

Predicting developmental toxicity through toxicogenomics

Birth Defects Research Part C: Embryo Today: Reviews, 2010
AbstractGlobal analysis of gene expression in target cells or tissues in response to a toxicant holds significant promise for predictive toxicology. Toxicants elicit a characteristic pattern of gene expression that is dependent on mechanism of action.
George P, Daston, Jorge M, Naciff
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Developmental toxicity of valproic acid

Life Sciences, 1991
Valproic acid is a very effective anticonvulsant agent widely used in the management of various forms of epilepsy. Administration of the drug during pregnancy results in increased incidence of congenital abnormalities in both humans and experimental animals.
D, Cotariu, J L, Zaidman
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Developmental Toxicity of Engineered Nanomaterials

2017
Abstract Engineering of nanosized particles provides new material properties due to large surface area, design and control of particle shape, and surface coatings. Toxicological properties of nanoparticles may therefore differ from bulk material. Developmental toxicity of nanoparticles may occur due to “traditional” toxicity, relating to specific ...
Hougaard K. S., Campagnolo L., Fadeel B., Gulumian M., Kagan V. E., Moller P., Jacobsen N. R., Savolainen K. M.   +7 more
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Developmental toxicity screening in zebrafish

Birth Defects Research Part C: Embryo Today: Reviews, 2011
Given the ever-increasing toxic exposure ubiquitously present in our environment as well as emerging evidence that these exposures are hazardous to human health, the current rodent-based regulations are proving inadequate. In the process of overhauling risk assessment methodology, a nonrodent test organism, the zebrafish, is emerging as tractable for ...
Catherine W, McCollum, Nicole A, Ducharme, Maria, Bondesson, Jan-Ake, Gustafsson   +3 more
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Developmental Exposure to Environmental Toxicants

Pediatric Clinics of North America, 2015
Children interact with the physical environment differently than adults, and are uniquely susceptible to environmental toxicants. Routes of absorption, distribution, metabolism, and target organ toxicities vary as children grow and develop. This article summarizes the sources of exposure and known adverse effects of toxicants that are ubiquitous in our
Alison J, Falck, Sandra, Mooney, Shiv S, Kapoor, Kimberly M R, White, Cynthia, Bearer, Dina, El Metwally   +5 more
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Developmental toxicity of one marine dinoflagellate toxicant - Saxitoxin

Planta Medica, 2012
This journal issue entitled: 8th Joint Meeting of AFERP, ASP, GA, PSE and SIF ... 2012. The abstracts' web site is located at https://www.thieme-connect.de/ejournals/issue/10.1055/s-002-23510/grouping/020261/10.1055/s ...
Tian, L, Wang, M
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Developmental Toxicity Testing of Vaccines

2012
Preventative and therapeutic vaccines are increasingly used during pregnancy and present special considerations for developmental toxicity testing. The various components of the vaccine formulation (i.e., protein or polysaccharide antigen, adjuvants, and excipients) need to be assessed for direct effects on the developing conceptus.
Paul C, Barrow, Linda, Allais
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Toxicity Testing, Developmental

2005
Teratology, the original term for the study of birth defects, is now better designated developmental toxicology. Developmental toxicity is defined as any structural or functional alteration caused by environmental insult that interferes with normal growth, differentiation, development, and/or behavior.
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Maternal factors in developmental toxicity

Teratogenesis, Carcinogenesis, and Mutagenesis, 1987
AbstractThe maternal organism provides the developing embryo with its physical environment, nutrients, and a mechanism for eliminating metabolic wastes. Since the physiological state of the pregnant female affects her ability to provide those requirements for the developing embryo, it is not surprising that there are maternal factors that can affect ...
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NSAIDs and developmental toxicity

Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2003
Melissa S, Tassinari, Jon C, Cook, Mark E, Hurtt   +2 more
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