Results 281 to 290 of about 2,744,821 (349)

Developmental Toxicants Risk Assessment

Pediatrics, 1992
To The Editor.— Because of their physical vulnerability and diminutive stature, infants and children often are assumed by the general public and by some health professionals to be more susceptible to the potential toxic effects of the chemicals found in the environment.
P S, Guzelian, C J, Henry, W H, Farland, S S, Olin   +3 more
openaire   +2 more sources

Developmental toxicity of methylamines in mice

Journal of Toxicology and Environmental Health, 1991
Monomethylamine (MMA), dimethylamine (DMA), and trimethylamine (TMA) are endogenous substances as well as metabolites of methyl isocyanate, the chemical involved in the 1984 accident at Bhopal, India. Although methylamines exert several toxic effects including inhibition of protein turnover and oocyte RNA synthesis, their reproductive toxicity has not ...
I, Guest, D R, Varma
openaire   +2 more sources

Zinc oxide nanoparticles impacts: cytotoxicity, genotoxicity, developmental toxicity, and neurotoxicity

Toxicology Mechanisms and Methods, 2019
Zinc oxide (ZnO) is the most commonly used nanoparticles among different nanoparticles. Its applications ranged from personal care products, sensors, antibacterial creams, and biomedical applications.
Sanjiv Singh
semanticscholar   +1 more source

Developmental toxicity and neurotoxicity of penconazole enantiomers exposure on zebrafish (Danio rerio).

Environmental Pollution, 2020
Penconazole is a widely used chiral triazole bactericide that may adversely affect the environment. It contains two corresponding enantiomers and there may be differences in toxicity between the isomers.
Ming Jia, Miaomiao Teng, Sinuo Tian, Jin Yan, Zhiyuan Meng, Sen Yan, Ruisheng Li, Zhiqiang Zhou, Wentao Zhu   +8 more
semanticscholar   +1 more source

Reproductive and Developmental Toxicity of Phthalates

Journal of Toxicology and Environmental Health, Part B, 2009
The purposes of this review are to (1) evaluate human and experimental evidence for adverse effects on reproduction and development in humans, produced by exposure to phthalates, and (2) identify knowledge gaps as for future studies. The widespread use of phthalates in consumer products leads to ubiquitous and constant exposure of humans to these ...
Lyche, J.L., Gutleb, A.C., Bergman, A., Eriksen, G.S., Murk, A.J., Ropstad, E., Saunders, M., Skaare, J.U.   +7 more
openaire   +3 more sources

Photo-Oxidative Degradation Mitigated the Developmental Toxicity of Polyamide Microplastics to Zebrafish Larvae by Modulating Macrophage-Triggered Proinflammatory Responses and Apoptosis.

Environmental Science and Technology, 2020
Microplastics (MPs) are ubiquitous in the environment and pose substantial threats to the water ecosystem. However, the impact of natural aging of MPs on their toxicity has rarely been considered.
Wei Zou, Mengli Xia, K. Jiang, Zhiguo Cao, Xingli Zhang, Xiangang Hu   +5 more
semanticscholar   +1 more source

Human developmental toxicity and mutagenesis

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1998
A previously described SAR model of human developmental toxicity was analyzed further. The model shows a number of mechanistic similarities with SAR models of other toxicological phenomena (systemic toxicity, chromosomal and genomic effects). This implies that there are many targets associated with developmental effects.
H S, Rosenkranz, Y P, Zhang, O T, Macina, D R, Mattison, G, Klopman   +4 more
openaire   +2 more sources

Exposure to pyrimethanil induces developmental toxicity and cardiotoxicity in zebrafish.

Chemosphere, 2020
Pyrimethanil is a broad-spectrum fungicide commonly used in the prevention and treatment of Botrytis cinerea. However, little information is available in the literature to show the toxicity of Pyrimethanil to cardiac development.
Yunlong Meng, Keyuan Zhong, Ju-hua Xiao, Yong Huang, You Wei, L. Tang, Suping Chen, Juan Wu, Jinze Ma, Zigang Cao, Xinjun Liao, Huiqiang Lu   +11 more
semanticscholar   +1 more source

Developmental toxicity of isomalt in rats

Food and Chemical Toxicology, 1989
The sugar replacer isomalt, a 1:1 mixture of the disaccharides glucopyranosylsorbitol and glucopyranosylmannitol, was incorporated in the diet of rats. Female Bay FB:30 rats were adapted to isomalt by feeding them a diet containing a gradually increasing amount of isomalt for several days, prior to mating. Subsequently, they were mated. Isomalt was fed
Waalkens-Berendsen, D.H., Koeter, H.B.W.M., Schluter, G., Renhof, M.   +3 more
openaire   +3 more sources

AHR-mediated ROS production contributes to the cardiac developmental toxicity of PM2.5 in zebrafish embryos.

Science of the Total Environment, 2019
Recent studies have shown an association between maternal exposure to ambient fine particle matter (PM2.5) and congenital heart defects in the offspring, but the underlying molecular mechanisms are yet to be elucidated.
Fei Ren, Cheng Ji, Yujie Huang, Stanley Aniagu, Yan Jiang, Tao Chen   +5 more
semanticscholar   +1 more source