Results 301 to 310 of about 2,744,821 (349)

Developmental toxicity of chlorpropham in mice

Reproductive Toxicology, 1997
The present studies were designed to evaluate the developmental toxicity of chlorpropham in mice. The first study was conducted to determine administration time, and the second study was designed to evaluate dose-response effects. Chlorpropham was administered to pregnant mice by gavage on Days 8, 8.3, 9, 9.3, 10, and 11 of gestation at a level of 3000
T, Tanaka, T, Fujitani, O, Takahashi, S, Oishi, M, Yoneyama   +4 more
openaire   +2 more sources

Developmental toxicity of cobalt in the rat

Journal of Toxicology and Environmental Health, 1988
To determine the potential developmental toxicity of cobalt, pregnant Sprague-Dawley rats were given by gavage a daily dose of 0, 25, 50; and 100 mg/kg cobalt(II) chloride on d 6-15 of gestation. Females were sacrificed on d 20. Maternal effects included significant reductions in weight gain and food consumption, particularly at 100 mk/kg.d. Hematocrit,
J L, Paternain, J L, Domingo, J, Corbella   +2 more
openaire   +2 more sources

Size-dependent maternal-fetal transfer and fetal developmental toxicity of ZnO nanoparticles after oral exposures in pregnant mice.

Ecotoxicology and Environmental Safety, 2019
The widespread application of nanomaterial-based products has caused safety concerns worldwide, especially for susceptible pregnant population. Here, we revealed the effect of the size of ZnO nanoparticles (ZnO NPs) on placental and fetal developmental ...
Chuanfeng Teng, Jianbo Jia, Zhiping Wang, V. Sharma, B. Yan   +4 more
semanticscholar   +1 more source

Developmental toxicity of valproic acid

Life Sciences, 1991
Valproic acid is a very effective anticonvulsant agent widely used in the management of various forms of epilepsy. Administration of the drug during pregnancy results in increased incidence of congenital abnormalities in both humans and experimental animals.
D, Cotariu, J L, Zaidman
openaire   +2 more sources

Macrolides induce severe cardiotoxicity and developmental toxicity in zebrafish embryos.

Science of the Total Environment, 2019
Macrolide antibiotics (MALs) are widely used for both human and animal health. Most MALs and their metabolites transfer into aquatic organisms and environment resulting in violent consequences.
Zhaoyang Yan, Xiaoyong Huang, Yangzhouyun Xie, Meirong Song, Kui Zhu, S. Ding   +5 more
semanticscholar   +1 more source

Developmental toxicity in zebrafish exposed to polyethylene microplastics under static and semi-static aquatic systems.

Science of the Total Environment, 2019
Different studies have reported the ecotoxicological effects of polyethylene microplastics (PE MPs) on aquatic organisms; however, little is known about their toxicity in the early life stages of aquatic vertebrates living in freshwater ecosystems. Thus,
G. Malafaia, Andreza Martins de Souza, A. C. Pereira, S. Gonçalves, Amanda Pereira da Costa Araújo, Renan Xavier Ribeiro, T. L. Rocha   +6 more
semanticscholar   +1 more source

In Silico Models for Developmental Toxicity

2022
Modeling developmental toxicity has been a challenge for (Q)SAR model developers due to the complexity of the endpoint. Recently, some new in silico methods have been developed introducing the possibility to evaluate the integration of existing methods by taking advantage of various modeling perspectives. It is important that the model user is aware of
Marco, Marzo, Alessandra, Roncaglioni, Sunil, Kulkarni, Tara S, Barton-Maclaren, Emilio, Benfenati   +4 more
openaire   +2 more sources

Effects of spinetoram on the developmental toxicity and immunotoxicity of zebrafish.

Fish and Shellfish Immunology, 2019
Our study investigated the effects of spinetoram on the developmental toxicity and immunotoxicity of zebrafish. 10 h post-fertilization (hpf) zebrafish embryos were exposed to several concentrations of spinetoram (0, 5.0 mg/L, 7.5 mg/L, 10 mg/L) for up ...
Bo Cheng, Hua Zhang, Kun Jia, E. Li, Shouhua Zhang, Huiyun Yu, Zigang Cao, Guanghua Xiong, Chengyu Hu, Huiqiang Lu   +9 more
semanticscholar   +1 more source

Developmental toxicity of dichloroacetate in the rat

Teratology, 1992
AbstractDichloroacetic acid (DCA) is a principal by‐product of the chlorine disinfection of water containing humic and fulvic acids, and is also a drug of interest in the therapeutic management of metabolic disorders. The developmental effects of DCA were evaluated in the pregnant Long‐Evans rat.
M K, Smith, J L, Randall, E J, Read, J A, Stober   +3 more
openaire   +2 more sources

Developmental toxicity of diacetoxyscirpenol in the mouse

Toxicology, 1987
Mycotoxins (frequently referred to as secondary metabolites of toxigenic fungi) are commonly found in foodstuffs and are important because of their association with disease. The mycotoxin diacetoxyscirpenol, or 3-hydroxy-4,15-diacetoxy-12,13-epoxytrichothec-9-ene (DAS), is produced by numerous species of Fusarium and is reportedly toxic to humans and ...
K, Mayura, E E, Smith, B A, Clement, R B, Harvey, L F, Kubena, T D, Phillips   +5 more
openaire   +2 more sources