Results 311 to 320 of about 2,744,821 (349)

Maternal exposure causes mitochondrial dysfunction in brain, liver, and heart of mouse fetus: An explanation for perfluorooctanoic acid induced abortion and developmental toxicity

Environmental Toxicology, 2019
Perfluorooctanoic acid (PFOA) is an octanoic acid and is found in wildlife and humans. We have investigated mitochondrial toxicity in isolated mitochondria from, placenta, brain, liver, and heart after oral exposure with PFOA in mice during gestational ...
A. Salimi, Mahnia Nikoosiar Jahromi, J. Pourahmad   +2 more
semanticscholar   +1 more source

Developmental Exposure to Environmental Toxicants

Pediatric Clinics of North America, 2015
Children interact with the physical environment differently than adults, and are uniquely susceptible to environmental toxicants. Routes of absorption, distribution, metabolism, and target organ toxicities vary as children grow and develop. This article summarizes the sources of exposure and known adverse effects of toxicants that are ubiquitous in our
Alison J, Falck, Sandra, Mooney, Shiv S, Kapoor, Kimberly M R, White, Cynthia, Bearer, Dina, El Metwally   +5 more
openaire   +2 more sources

Developmental toxicity screening in zebrafish

Birth Defects Research Part C: Embryo Today: Reviews, 2011
Given the ever-increasing toxic exposure ubiquitously present in our environment as well as emerging evidence that these exposures are hazardous to human health, the current rodent-based regulations are proving inadequate. In the process of overhauling risk assessment methodology, a nonrodent test organism, the zebrafish, is emerging as tractable for ...
Catherine W, McCollum, Nicole A, Ducharme, Maria, Bondesson, Jan-Ake, Gustafsson   +3 more
openaire   +2 more sources

Reproductive and developmental toxicity study of caffeic acid in mice.

Food and Chemical Toxicology, 2019
Caffeic acid is an antioxidant commonly used to promote hematopoiesis and hemostasis. However, little is known about its systemic safety profile in reproduction and development.
Yang Liu, S. Qiu, Lingjun Wang, Na Zhang, Yan Shi, Hai Zhou, Xinguang Liu, Linlin Shao, Xue-na Liu, Jian Chen, M. Hou   +10 more
semanticscholar   +1 more source

Developmental toxicity of fipronil in early development of zebrafish (Danio rerio) larvae: Disrupted vascular formation with angiogenic failure and inhibited neurogenesis.

Journal of Hazardous Materials, 2019
Fipronil has been widely used in agriculture to prevent aggressive insects from damaging agricultural products. Fipronil residues circulate in the environment and they have been detected in non-targeted organisms in aquatic environments.
Hahyun Park, Jin-young Lee, Sunwoo Park, G. Song, W. Lim   +4 more
semanticscholar   +1 more source

The Developmental Toxicity Testing of Biologics

2012
The characteristics of biologic drugs, as compared with small molecules, confer significant advantages for both the drug developer and the prospective patients. The necessity for, and the timing of, developmental toxicity testing in the preclinical program must be considered.
openaire   +2 more sources

Perspectives On Reproductive and Developmental Toxicity

Toxicology and Industrial Health, 1986
Human reproduction and development is a cycle of interdependent events. Virtually all of its phases have been shown to be the primary target of one or more non-mutagenic exogenous agents (Table 1). Such agents interfere with certain of the countless epigenetic or ontogenic events essential for normal completion of the cycle. Mutagens disrupt this cycle
openaire   +2 more sources

NSAIDs and developmental toxicity

Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2003
Melissa S, Tassinari, Jon C, Cook, Mark E, Hurtt   +2 more
openaire   +2 more sources

Developmental Toxicity — Magnitude of the Problem

1994
Human reproduction is a complex process, and can be disturbed in many phases by host as well as environmental factors. It has therefore been difficult to distinguish environmental causes of abnormal development from other factors related to the parents’ innate properties.
openaire   +2 more sources

Developmental Toxicity Guidelines Critique

JAPCA, 1987
The toxicity guidelines include the following major sections: definitions and terminology; qualitative assessment which provides a brief description of the most commonly used developmental toxicity experimental protocol; endpoint assays; functional effects; short term testing; pharmacokinetics; studies of humans; structure-activity relationships ...
openaire   +2 more sources