Results 81 to 90 of about 275,688 (307)

Integrated mRNA- and miRNA-sequencing analyses unveil the underlying mechanism of tobacco pollutant-induced developmental toxicity in zebrafish embryos

Journal of Translational Medicine
Tobacco pollutants are prevalent in the environment, leading to inadvertent exposure of pregnant females. Studies of these pollutants' toxic effects on embryonic development have not fully elucidated the potential underlying mechanisms.
Jiasheng Chen, Yuxin Lin, Deyi Gen, Wanxian Chen, Rui Han, Hao Li, Shijie Tang, Shukai Zheng, Xiaoping Zhong   +8 more
doaj   +1 more source

Leveraging Epidemiology to Improve Risk Assessment. [PDF]

, 2011
The field of environmental public health is at an important crossroad. Our current biomonitoring efforts document widespread exposure to a host of chemicals for which toxicity information is lacking.
Burke, Thomas A, Fox, Mary A, Nachman, Keeve E, Rodricks, Joseph V, Sheehan, Mary C, Woodruff, Tracey J   +5 more
core  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Enantioselective Toxicity of Tetramethrin to Different Developmental Stages of Zebrafish (Danio rerio)

Toxics
Chiral pesticides exhibit enantioselective differences in processes such as biological absorption, metabolism, and toxic effects. Organisms have different physiological characteristics at different developmental stages. Therefore, conducting enantiomeric
Jiqin Feng, Xintong Xu, Wenfei Huang, Honghong Gong, Xiaohui Sun, Jinsong Liu, Chao Xu, Weiping Liu   +7 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Particulate Matter 2.5 Induced Developmental Cardiotoxicity in Chicken Embryo and Hatchling

Frontiers in Pharmacology, 2020
Particulate matter poses health risk to developing organisms. To investigate particulate matters with a diameter smaller than 2.5 um (PM2.5)-induced developmental cardiotoxicity, fertile chicken eggs were exposed to PM2.5 via air cell injection at doses ...
Qixiao Jiang, Chao Zhang, Shen Chen, Limei Shi, Dao Chuan Li, Na Lv, Lianhua Cui, Yanxia Chen, Yuxin Zheng   +8 more
doaj   +1 more source

Fish and amphibians as test organisms for evaluation of effects caused by chemicals [PDF]

, 2007
A large number of chemicals can contaminate aquatic environments and therefore be exposed to fish and amphibians during their sensitive stages of development.
Carlsson, Gunnar
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Evaluation of the Developmental Toxicity Induced by E804 in Zebrafish Embryos

Frontiers in Pharmacology, 2020
E804, a derivative of indirubin, have multi-biological activities such as anticancer and anti-inflammatory activities, but little is known about its developmental toxicity.
Rongchun Wang, Kechun Liu, Yun Zhang, Xiqiang Chen, Xue Wang   +4 more
doaj   +1 more source

Effect of phenytoin on development and life-history traits of Drosophila melanogaster [PDF]

, 2013
Phenytoin is an antiepileptic drug which has been used in the present study to assess its effect on developmental toxicity from egg to adult eclosion and also life-history traits in Drosophila melanogaster.
Gayathri, D.S., Harini, B.P.
core