Results 101 to 110 of about 373,948 (350)
Hierarchical microplates as drug depots with controlled geometry, rigidity and therapeutic efficacy [PDF]
arXiv, 2019 A variety of microparticles have been proposed for the sustained and localized delivery of drugs whit the objective of increasing therapeutic indexes by circumventing filtering organs and biological barriers. Yet, the geometrical, mechanical and therapeutic properties of such microparticles cannot be simultaneously and independently tailored during the
arxiv
Targeting dexamethasone to macrophages
Drug Delivery, 1995 AbstractDexamethasone-21-phosphate (Dex-21-P) was encapsulated in human erythrocytes by a procedure of hypotonic hemolysis and isotonic resealing in a wide range of concentrations (0.2 to 8.5 mm). The erythrocyte membrane was then modified by the addition of Zn and bis(sulfosuccinimidyl)suberate inducing the formation of stable antigenic sites that are
MAGNANI, MAURO +4 more
openaire +3 more sources
Intrinsically Soft Implantable Electronics for Long‐term Biosensing Applications
Advanced Sensor Research, EarlyView.Intrinsically soft implantable biosensors address the mechanical mismatch of conventional rigid implants, improving biocompatibility and stability. This review explores soft encapsulation matrices, stretchable conductors, implantation strategies, and chronic fixation techniques.
Su Hyeon Lee +5 more
wiley +1 more source
Asparaginase Potentiates Glucocorticoid-Induced Osteonecrosis in a Mouse Model.
PLoS ONE, 2016 Osteonecrosis is a common dose-limiting toxicity of glucocorticoids. Data from clinical trials suggest that other medications can increase the risk of glucocorticoid-induced osteonecrosis.
Chengcheng Liu +8 more
doaj +1 more source
Emerging Therapeutic Strategies for Hearing Loss
Advanced Therapeutics, EarlyView.Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han +9 more
wiley +1 more source
Efficacy of Three Different Prophylactic Treatments for Postoperative Nausea and Vomiting after Vitrectomy: A Randomized Clinical Trial [PDF]
, 2019 Postoperative nausea and vomiting (PONV) after vitreoretinal surgery may potentially be associated with severe complications, such as suprachoroidal hemorrhage.
Astuto, M. +18 more
core +3 more sources
Drug Design, Development and Therapy, 2016 Cody P Coyne,1 Lakshmi Narayanan2 1Department of Basic Sciences, 2Department of Clinical Sciences, College of Veterinary Medicine, Mississippi State University, Starkville, MS, USA Purpose: Corticosteroids are effective in the management of a variety ...
Coyne CP, Narayanan L
doaj
Advanced Science, EarlyView.The article presents the development of artificial lipid droplets (aLDs) as biomimetic nanocarriers to enhance intramuscular fat (IMF) content in pigs. These aLDs, loaded with oleic acid, significantly increase IMF by up to 35% in muscle tissues without adverse side effects. This innovative approach improves pork quality by enhancing marbling, offering
Pengxiang Zhao +8 more
wiley +1 more source
Regulation of transforming growth factor-beta 1 gene expression by glucocorticoids in normal human T lymphocytes. [PDF]
, 1991 Glucocorticoids (GC) modulate immune function in a number of ways, including suppression of T cell proliferation and other IL-2-mediated T cell functions.
AyanlarBatuman, O. +3 more
core +1 more source
Advanced Science, EarlyView.Based on a well‐established in vitro directed differentiation model and an integrated analysis of high‐density cell lineage trees (CLTs) and single‐cell transcriptomes, it is demonstrated that many subclones are formed by sub‐CLTs resembling each other in terms of both cell type compositions and topological structures.
Xiaoyu Zhang +14 more
wiley +1 more source