Results 101 to 110 of about 496,062 (355)

Glucocorticoids for human skin: New aspects of the mechanism of action [PDF]

, 2005
Topical glucocorticoids have always been considered first-line drugs for inflammatory diseases of the skin and bronchial system. Applied systemically, glucocorticoids are used for severe inflammatory and immunological diseases and the inhibition of ...
Ahmed, M., Holtje, H. D., Kleuser, B., Korting, Hans Christian, Schäfer-Korting, Monika   +4 more
core   +1 more source

Adverse side‐effects of dexamethasone in surgical patients – an abridged Cochrane systematic review

Anaesthesia, 2019
In the peri‐operative period, dexamethasone is widely and effectively used for prophylaxis of postoperative nausea and vomiting. The objective of this meta‐analysis was to assess the adverse effects of an incidental steroid load of dexamethasone in adult
J. Polderman, V. Farhang-Razi, S. Dieren, Peter Kranke, J. DeVries, M. Hollmann, B. Preckel, J. Hermanides   +7 more
semanticscholar   +1 more source

Biomimetic, Suturable, and Extensible Electrospun Scaffolds for Lower Urinary Tract Surgical Reconstruction

Advanced Healthcare Materials, EarlyView.
Biomimetic, suturable, biodegradable fibrous scaffolds are engineered to mimic the tensile properties of LUT tissue using photocrosslinked 5:5% weight per volume elastin‐like peptide and methacrylated gelatin (5E5G). In vitro, urothelium, smooth muscle, and fibroblast 7 day cytocompatibility is demonstrated.
Renea M. Sturm, Yadi Huo, Felix Yiu, Yimin Gu, Ronak Afshari, Zijian Zhong, Ruby Jimenez, Rebekah Jung, Aljohn Cabuan, Keshav Shukla, Karen Harrison, Judy Su, George E. Aninwene II, Victoria Lee, Mahsa Ghovvati, Kaavian Shariati, Nicholas Jackson, Song Li, Nasim Annabi   +18 more
wiley   +1 more source

Conditioned Media from Mechanically Stimulated Macrophages Upregulate Osteogenic Genes in Human Mesenchymal Stromal Cells

Advanced Healthcare Materials, EarlyView.
Bone fracture healing is a complex, timely orchestrated scenario involving multiple cell types and a plethora of cytokines and regulatory factors. To gain further insight, an in vitro model to a) study macrophage polarization under mechanical load in a fibrin hydrogel and b) subsequently assess the effect of conditioned media derived from macrophages ...
Anne Géraldine Guex, Ursula Menzel, Yann Ladner, Angela R. Armiento, Martin J. Stoddart   +4 more
wiley   +1 more source

Dexamethasone-(C21-phosphoramide)-[anti-EGFR]: molecular design, synthetic organic chemistry reactions, and antineoplastic cytotoxic potency against pulmonary adenocarcinoma (A549)

Drug Design, Development and Therapy, 2016
Cody P Coyne,1 Lakshmi Narayanan2 1Department of Basic Sciences, 2Department of Clinical Sciences, College of Veterinary Medicine, Mississippi State University, Starkville, MS, USA Purpose: Corticosteroids are effective in the management of a variety ...
Coyne CP, Narayanan L
doaj  

Nanocarrier‐Based Targeting of Pattern Recognition Receptors as an Innovative Strategy for Enhancing Sepsis Therapy

Advanced Healthcare Materials, EarlyView.
This review highlights recent progress in nanocarriers targeting pattern recognition receptors (PRRs), including Toll‐like and NOD‐like receptors, for enhancing the treatment of bacterial sepsis and related complications. These nanomedicines deliver antibiotics and anti‐inflammatory agents while modulating immune responses.
Eman A. Ismail, Vincent O. Nyandoro, Calvin A. Omolo, Thirumala Govender   +3 more
wiley   +1 more source

Use and Outcomes of Dexamethasone in the Management of Malignant Small Bowel Obstruction

Annals of Surgery Open
Objective:. To describe rates of dexamethasone use in the nonoperative management of malignant small bowel obstruction (mSBO) and their outcomes. Background:. mSBO is common in patients with advanced abdominal-pelvic cancers.
Frank F. Yang, MD, Elina Serrano, MD, Kyle S. Bilodeau, MD, Michael Weykamp, MD, Caitlin J. Silvestri, MD, Ashleigh C. M. Bull, MD, Brenda Lin, MD, Sara L. Schaefer, MD, Colette Galet, PhD, Luis J. Garcia, MD, FACS, Baraka Gitonga, BS, David T. Kolodziej, BS, Samantha Esposito, BS, Molly Parker-Brigham, BS, Rohan Luhar, BS, Avinash Mamgain, MS, Kendrick C. Brown, BS, Summer Dewdney, MD, Thea P. Price, MD, FACS, Nicole Siparsky, MD, FACS, Sarah Knerr, PhD, Pauline K. Park, MD, FACS, Sabrina Sanchez, MD, FACS, Dionne A. Skeete, MD, FACS, Katherine N. Fischkoff, MD, FACS, David R. Flum, MD, FACS   +25 more
doaj   +1 more source

An Organ‐on‐Chip Platform for Strain‐Controlled, Tissue‐Specific Compression of Cartilage and Mineralized Osteochondral Interface to Study Mechanical Overloading in Osteoarthritis

Advanced Healthcare Materials, EarlyView.
A mechanically active OsteoChondral Unit (OCU)‐on‐Chip platform mimicking the OCU's functional anatomy and the strain gradient across the osteochondral interface is presented. Upon compartment‐specific hyperphysiological compression, the model replicates mechanisms observed in osteoarthritis (OA) progression, such as calcium crystal accumulation ...
Andrea Mainardi, Anastasiya Börsch, Paola Occhetta, Robert Ivanek, Martin Ehrbar, Lisa Krattiger, Philipp Oertle, Marko Loparic, Ivan Martin, Marco Rasponi, Andrea Barbero   +10 more
wiley   +1 more source

Influence of 17 beta-estradiol, progesterone, and dexamethasone on diapedesis and viability of bovine blood polymorphonuclear leukocytes [PDF]

, 2004
The aim of the current study was to investigate whether polymorphonuclear leukocyte (PMN) diapedesis and viability are influenced by steroid hormones.
Burvenich, Christian, Duchateau, Luc, Lamote, Inge, Meyer, Evelyne   +3 more
core   +1 more source

Therapeutic Implants: Mechanobiologic Enhancement of Osteogenic, Angiogenic, and Myogenic Responses in Human Mesenchymal Stem Cells on 3D‐Printed Titanium Truss

Advanced Healthcare Materials, EarlyView.
This study investigates a synergistic effect between 3D‐printed surface features and mechanical micro‐strain in enhancing the osteogenic, angiogenic, and myogenic responses of human mesenchymal stem cells (hMSCs). Load‐induced mechanotransduction, facilitated by the implant's architectural design, significantly amplifies hMSC differentiation.
Se‐Hwan Lee, Ali Kiapour, Brendan D. Stoeckl, Ellen Y. Zhang, Matthew R. Begley, Jarod Oldham, Lewis Harrison, Jessee Hunt, Robert L. Mauck, Su Chin Heo   +9 more
wiley   +1 more source