Results 191 to 200 of about 510,342 (390)

DKK3 Initially Preserves Acinar Integrity Through MEK‐Fos Signaling, but Later Switches to an Oncogenic Role in Pancreatic Cancer

Advanced Science, EarlyView.
In pancreatic cancer, the protein DKK3 is found to play a complex role: it initially slows early tumor growth but later promotes tumor aggressiveness. DKK3 expression evolves during progression and drives cancer severity by orchestrating cellular and molecular signaling pathways.
Dharini Srinivasan, Elodie Roger, Lukas Perkhofer, Eleni Zimmer, Thomas F.E. Barth, Julia P. Mosler, Anna Härle, Stephanie E. Weissinger, Nadine T. Gaisa, Peter Möller, Nico Fischer, Chantal Allgöwer, J.‐Matthias Löhr, Dirk Grimm, Thomas Seufferlein, Stefan Liebau, Ninel Azoitei, Michael K. Melzer, Frank Arnold, Johann Gout, Alexander Kleger   +20 more
wiley   +1 more source

The Pathogenic Roles of Local Vitamin D Metabolism Defect in Valve Inflammation and Calcification

Advanced Science, EarlyView.
This study identifies the valvular interstitial cell populations responsible for valvular calcification induced by hyperphosphatemia and likely aging, uncovers local vitamin D metabolism defect‐induced inflammation as a critical pathogenic factor of calcific aortic valve disease, and highlights active vitamin D and ERK inhibitor as potential preventive
Ruichen Yang, Chong Han, Yangli Xie, Shoutao Qiu, Shaoyang Zhang, Jingjia He, Zejian Wang, Zhenlin Zhang, Huijuan Liu, Lin Chen, Baojie Li   +10 more
wiley   +1 more source

Influence of prenatal exposure to dexamethasone on neurodevelopmental behaviour [PDF]

, 2020
Alexandra Cruz, Carsten Ulrik Henriques, A. Ferreira, Sofia Galvão, Christian Neves, Rita Gaspar, A. F. Ambrósio, Catarina A. Gomes, Filipa I. Baptista   +8 more
openalex   +1 more source

Efficacy of intravitreal dexamethasone implant used as monotherapy for the treatment of macular edema in non-infectious uveitis: a retrospective analysis [PDF]

, 2023
Rishi B. Gupta, Julius Vladimir Ilin, Chloe Gottlieb   +2 more
openalex   +1 more source

Epigenetic Targeting of Senescent Cells Prevents the Deleterious Effects of Obstructive Sleep Apnea on Growing Skeleton

Advanced Science, EarlyView.
Chronic intermittent hypoxia induces premature senescence of osteoprogenitor cells in long bone metaphysis via HIF1α‐mediated EZH2‐H3k27me3 downregulation, leading to impaired bone growth. Restoration of H3K27me3 level via UTX inhibition rescues osteogenesis and growth impairment in young mice.
Xiaonan Liu, Peilin Zhang, Zhongyi Su, Yong Feng, Zhenger Zhou, Sa Pang, Yicheng Wang, Jiacheng Hu   +7 more
wiley   +1 more source

Prospective cohort study evaluating risk factors for the development of pasture-associated laminitis in the United Kingdom [PDF]

, 2016
Arita, Asplin, Bailey, Bailey, Beltowski, Blakesley, Borer, Bremer, Brooks, Carter, Cywinska, Dallmeier, Efstathiou, El-Mesallamy, Fesus, Finding, Firshman, Frank, Frank, Giles, Giordano, Greiner, Heinrichs, Henneke, Hinckley, Holbrook, Hotta, Huang, Ingelsson, Johnson, Kearns, Kim, Kullmann, Laat, Lam, Lavoie-Lamoureux, Lim, Luszczynski, Lygren, Macieira, Maleki, Mattu, Morgan, Orth, Ouchi, Pischon, Pleasant, Pollock, Popot, Pratt, Ragab, Reimers, Robin, Rosen, Ruan, Ruan, Ryu, Salazar-Ortiz, Salonen, Sandhu, Schultz, Smith, Stephenson, Takiguchi, Torres, Treiber, Treiber, Treiber, Treiber, Troncoso, Trujillo, Wannamethee, Wray, Wyse, Yang   +74 more
core   +2 more sources

Dexamethasone nanomedicines for COVID-19

Nature Nanotechnology, 2020
T. Lammers, Alexandros Marios Sofias, R. van der Meel, R. Schiffelers, G. Storm, F. Tacke, S. Koschmieder, T. Brümmendorf, F. Kiessling, J. Metselaar   +9 more
semanticscholar   +1 more source

Endothelial BMP6 Drives Hemodynamic‐Dependent VSMCs Calcification in Carotid Atherosclerosis

Advanced Science, EarlyView.
The study demonstrates that endothelial cell (EC)‐derived BMP6 promotes the osteogenic differentiation of vascular smooth muscle cells (VSMCs) through cell‐cell interactions. Additionally, the researchers preliminarily explore the driving effect of hemodynamic factors on BMP6‐induced calcification and reveal the regulatory role of KLF4 on BMP6.
Shen Li, Shuang Cao, Peipei Li, Feng Zhang, Gangfeng Ren, Xin Wang, Jiawei Zhao, Chen Liu, Yuan Gao, Jie Xu, Yongjun Wang, Zongping Xia, Yuming Xu   +12 more
wiley   +1 more source

Sensitive Gold Nanostar-Based Adsorption Sensor for the Determination of Dexamethasone [PDF]

Riccarda Thelma MacDonald, Keagan Pokpas, Emmanuel I. Iwuoha, Candice Franke   +3 more
openalex   +1 more source

The effect of perioperative of dexamethasone on postoperative complications after pancreaticoduodenectomy (PANDEX): a study protocol for a pragmatic multicenter randomized controlled trial [PDF]

, 2023
Haoda Chen, Ying Wang, Chao Wang, Xiaojian Lu, Yilong Li, Bei Sun, Kuirong Jiang, Yudong Qiu, Rufu Chen, Liping Cao, Shi Chen, Yan Luo, Baiyong Shen   +12 more
openalex   +1 more source