Results 31 to 40 of about 236,981 (311)

Dexamethasone Sensitizes Cancer Stem Cells to Gemcitabine and 5-Fluorouracil by Increasing Reactive Oxygen Species Production through NRF2 Reduction

Life, 2021
Cancer stem cells (CSCs) have high tumor-initiating capacity and are resistant to chemotherapeutic reagents; thus eliminating CSCs is essential to improving the prognosis.
Shuhei Suzuki, Masahiro Yamamoto, Tomomi Sanomachi, Keita Togashi, Asuka Sugai, Shizuka Seino, Takashi Yoshioka, Masashi Okada, Chifumi Kitanaka   +8 more
doaj   +1 more source

Nanoparticle-in-Hydrogel Delivery System for the Sequential Release of Two Drugs

Pharmaceutics
Background/Objectives: Glioblastoma is the most common and lethal primary brain tumor. Patients often suffer from tumor- and treatment induced vasogenic edema, with devastating neurological consequences.
Demian van Straten, Jaime Fernández Bimbo, Wim E. Hennink, Tina Vermonden, Raymond M. Schiffelers   +4 more
doaj   +1 more source

The protective Effect of Nigella sativa on sperm parameter in mice treated with dexamethasone

مجله علمی دانشگاه علوم پزشکی کردستان, 2020
Background and Aim: Dexamethasone affects testis hemostasis through reduction of  testosterone level . In one study dexamethasone induced spermatogenesis defects through epithelial vacuolizations and sloughing of germ cell layer.
saeid miri, morteza abouzaripour, Mohammad Jafar Rezaie, Fardin Fathi, bahram nikkho, daem roshani, shiva khalesro, Erfan daneshi   +7 more
doaj  

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Effects of dexamethasone on intracochlear inflammation and residual hearing after cochleostomy: A comparison of administration routes. [PDF]

PLoS ONE, 2018
Preservation of residual hearing after cochlear implant is an important issue with regards to hearing performance. Various methods of steroid administration have been widely used in clinical practice to reduce inflammation and preserve residual hearing ...
Ah-Ra Lyu, Dong Hyun Kim, Seung Hun Lee, Dong-Sik Shin, Sun-Ae Shin, Yong-Ho Park   +5 more
doaj   +1 more source

Electrical pulse stimulation reflecting the episodic nature of real‐life exercise modulates metabolic and secretory profile of primary human myotubes

FEBS Open Bio, EarlyView.
Here, we introduced an intermittent electrical stimulation protocol mimicking the episodic nature of real‐life exercise in vitro by alternating low‐ and high‐frequency stimulation. In comparison with widely used continuous stimulation, it enhanced the rate of glucose and fatty acid oxidation, but not the myokine release.
Klára Gabrišová, Tímea Kurdiová, Daria Barkova, Natália Pálešová, Jana Babulicová, Silvia Tyčiaková, Marta Novotová, Mária Balážová, Miroslav Sabo, Václav Pustka, Jozef Ukropec, Barbara Ukropcová   +11 more
wiley   +1 more source

SYHA1813, A VEGFR and CSF1R Inhibitor, in Patients With Recurrent High‐Grade Gliomas: A Multicenter, Open‐Label Phase I Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recurrent high‐grade gliomas have a poor prognosis and limited therapeutic options. This study aimed to evaluate the safety and efficacy of SYHA1813, a dual inhibitor of VEGFR and CSF1R, in patients with recurrent high‐grade gliomas.
Zhuang Kang, Shenglan Li, Liang Wang, Qianxue Chen, Weiguo Hu, Ting Lei, Ying Mao, Jing Zhang, Xiaojun Xiang, Qiming Wang, Zhengwen He, Tao Sun, Yulei Wang, Mengqian Huang, Rong Zhang, Feng Chen, Wenbin Li   +16 more
wiley   +1 more source

Dexamethasone Therapy for Bacterial Meningitis: Better Never Than Late?

Canadian Journal of Infectious Diseases, 1994
A multicentre randomized controlled trial was conducted in children with bacterial meningitis using dexamethasone or placebo for four days within 24 h of starting antibiotics. Primary outcomes were hearing loss and neurological abnormalities at 12 months
Susan M King, Barbara Law, Joanne M Langley, Helen Heurter, Diane Bremner, Elaine E Wang, Ronald Gold   +6 more
doaj   +1 more source

yCD/HPyCD Mixtures as Solubilizer: Solid-State Characterization and Sample Dexamethasone Eye Drop Suspension

Journal of Pharmacy & Pharmaceutical Sciences, 2010
Purpose. Study the complexation of dexamethasone in combinations of y-cyclodextrin (yCD) and 2-hydroxypropyl-y-cyclodextrin (HPyCD) with emphasis on solid characterization and development of aqueous dexamethasone eye drop suspension for drug delivery ...
Phatsawee Jansook, Garnpimol C. Ritthidej, Haruhisa Ueda, Einar Stefánsson, Thorsteinn Loftsson   +4 more
doaj   +1 more source

Loss of Stat3 in Prx1+ Progenitors Impairs Molar Root Development

Advanced Biology, EarlyView.
Stat3 critically regulates mandibular first molar and alveolar bone morphogenesis. Conditional ablation of Stat3 disrupts the osteogenic capacity of Prx1+ mesenchymal progenitors, as evidenced across in vivo and in vitro models. Abstract Signal Transducer and Activator of Transcription 3 (Stat3) acts as a central transcriptional modulator coordinating ...
Xin Feng, Wangyu Luo, Yichen Yao, Lichieh Lin, Laiting Chan, Jiarui Lu, Zijing Huang, Jingyi Feng, Le Zhao, Xiaolei Zhang, Liu Yang   +10 more
wiley   +1 more source