Trial of Dexamethasone for Chronic Subdural Hematoma.
New England Journal of Medicine, 2020 BACKGROUND Chronic subdural hematoma is a common neurologic disorder that is especially prevalent among older people. The effect of dexamethasone on outcomes in patients with chronic subdural hematoma has not been well studied.
P. Hutchinson +32 more
semanticscholar +1 more source
Life, 2021 Cancer stem cells (CSCs) have high tumor-initiating capacity and are resistant to chemotherapeutic reagents; thus eliminating CSCs is essential to improving the prognosis.
Shuhei Suzuki +8 more
doaj +1 more source
Optimizing adipogenic transdifferentiation of bovine mesenchymal stem cells: a prominent role of ascorbic acid in FABP4 induction [PDF]
, 2020 Adipocyte differentiation of bovine adipose-derived stem cells (ASC) was induced by foetal bovine serum (FBS), biotin, pantothenic acid, insulin, rosiglitazone, dexamethasone and 3-isobutyl-1-methylxanthine, followed by incubation in different media to ...
Aschenbach, Jörg R. +6 more
core +1 more source
Nanoparticle-in-Hydrogel Delivery System for the Sequential Release of Two Drugs
PharmaceuticsBackground/Objectives: Glioblastoma is the most common and lethal primary brain tumor. Patients often suffer from tumor- and treatment induced vasogenic edema, with devastating neurological consequences.
Demian van Straten +4 more
doaj +1 more source
The protective Effect of Nigella sativa on sperm parameter in mice treated with dexamethasone
مجله علمی دانشگاه علوم پزشکی کردستان, 2020 Background and Aim: Dexamethasone affects testis hemostasis through reduction of testosterone level . In one study dexamethasone induced spermatogenesis defects through epithelial vacuolizations and sloughing of germ cell layer.
saeid miri +7 more
doaj
Dexamethasone in the management of covid -19
British medical journal, 2020 Preliminary trial results are mostly good news, but timing is ...
Raymond M. Johnson, J. Vinetz
semanticscholar +1 more source
Vascular endothelial growth factor production and regulation in rodent and human pituitary tumor cells in vitro [PDF]
, 2001 Angiogenesis, the formation of a new blood supply, is an essential step in tumorigenesis. Although vascular endothelial growth factor (VEGF) is known to be a very potent angiogenic factor in most solid tumors, little is known about its production and ...
Gloddek, Jutta +7 more
core +1 more source
Dexamethasone-induced immunosuppression: mechanisms and implications for immunotherapy
Journal of Immunotherapy for Cancer, 2018 BackgroundCorticosteroids are routinely utilized to alleviate edema in patients with intracranial lesions and are first-line agents to combat immune-related adverse events (irAEs) that arise with immune checkpoint blockade treatment.
Amber J. Giles +12 more
semanticscholar +1 more source
Concurrent Dexamethasone Limits the Clinical Benefit of Immune Checkpoint Blockade in Glioblastoma
Clinical Cancer Research, 2020 Purpose: Dexamethasone, a uniquely potent corticosteroid, is frequently administered to patients with brain tumors to decrease tumor-associated edema, but limited data exist describing how dexamethasone affects the immune system systemically and ...
J. Iorgulescu +22 more
semanticscholar +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source