Results 61 to 70 of about 373,948 (350)

Current and Future Cornea Chip Models for Advancing Ophthalmic Research and Therapeutics

Advanced Biology, EarlyView.
This review analyzes cornea chip technology as an innovative solution to corneal blindness and tissue scarcity. The examination encompasses recent developments in biomaterial design and fabrication methods replicating corneal architecture, highlighting applications in drug screening and disease modeling while addressing key challenges in mimicking ...
Minju Kim, Kanghoon Choi, Amy Lin, Jungkyu Kim   +3 more
wiley   +1 more source

Dr-COVID: Graph Neural Networks for SARS-CoV-2 Drug Repurposing [PDF]

arXiv, 2020
The 2019 novel coronavirus (SARS-CoV-2) pandemic has resulted in more than a million deaths, high morbidities, and economic distress worldwide. There is an urgent need to identify medications that would treat and prevent novel diseases like the 2019 coronavirus disease (COVID-19).
arxiv  

3D Bioprinting of Thick Adipose Tissues with Integrated Vascular Hierarchies

Advanced Functional Materials, Volume 35, Issue 12, March 18, 2025.
An advanced 3D bioprinting technique is used here to create thick adipose tissues with a central, vessel and extensive branching. The construct is made using alginate, gelatin and collagen‐based bioinks. Flow through the complex vessel network is demonstrated as well as its successful integration with a femoral artery following implantation in a rat ...
Idit Goldfracht, Majd Machour, Inbal Michael, Maria Bulatova, Janette Zavin, Shulamit Levenberg   +5 more
wiley   +1 more source

The Association of Oleic Acid and Dexamethasone Acetate into Nanocapsules Enables a Reduction in the Effective Corticosteroid Dose in a UVB Radiation-Induced Sunburn Model in Mice

Pharmaceutics
Dexamethasone has a high anti-inflammatory efficacy in treating skin inflammation. However, its use is related to the rebound effect, rosacea, purple, and increased blood glucose levels.
Natháli Schopf Pegoraro, Mailine Gehrcke, Camila Camponogara, Maria Fernanda Pessano Fialho, Letícia Cruz, Sara Marchesan Oliveira   +5 more
doaj   +1 more source

Dexamethasone Therapy for Bacterial Meningitis: Better Never Than Late?

Canadian Journal of Infectious Diseases, 1994
A multicentre randomized controlled trial was conducted in children with bacterial meningitis using dexamethasone or placebo for four days within 24 h of starting antibiotics. Primary outcomes were hearing loss and neurological abnormalities at 12 months
Susan M King, Barbara Law, Joanne M Langley, Helen Heurter, Diane Bremner, Elaine E Wang, Ronald Gold   +6 more
doaj   +1 more source

yCD/HPyCD Mixtures as Solubilizer: Solid-State Characterization and Sample Dexamethasone Eye Drop Suspension

Journal of Pharmacy & Pharmaceutical Sciences, 2010
Purpose. Study the complexation of dexamethasone in combinations of y-cyclodextrin (yCD) and 2-hydroxypropyl-y-cyclodextrin (HPyCD) with emphasis on solid characterization and development of aqueous dexamethasone eye drop suspension for drug delivery ...
Phatsawee Jansook, Garnpimol C. Ritthidej, Haruhisa Ueda, Einar Stefánsson, Thorsteinn Loftsson   +4 more
doaj   +1 more source

Dexamethasone Treatment of Newborn Rats Decreases Cardiomyocyte Endowment in the Developing Heart through Epigenetic Modifications. [PDF]

PLoS ONE, 2015
The potential adverse effect of synthetic glucocorticoid, dexamethasone therapy on the developing heart remains unknown. The present study investigated the effects of dexamethasone on cardiomyocyte proliferation and binucleation in the developing heart ...
Maresha S Gay, Yong Li, Fuxia Xiong, Thant Lin, Lubo Zhang   +4 more
doaj   +1 more source

Information Mining for COVID-19 Research From a Large Volume of Scientific Literature [PDF]

arXiv, 2020
The year 2020 has seen an unprecedented COVID-19 pandemic due to the outbreak of a novel strain of coronavirus in 180 countries. In a desperate effort to discover new drugs and vaccines for COVID-19, many scientists are working around the clock. Their valuable time and effort may benefit from computer-based mining of a large volume of health science ...
arxiv  

Mesenchymal Stem Cells‐Derived Extracellular Vesicles Mimetics as Osteoinductive Mediators for Bone Healing

Advanced Functional Materials, EarlyView.
Mesenchymal stem cell‐derived nanoghosts (MSC‐NGs) mimic naturally secreted extracellular vesicles (MSC‐EVs) in structure and physicochemical properties but can be synthesized at more translatable yields. As osteogenic agents, MSC‐NGs demonstrate superior outcomes compared to MSC‐EVs.
Antoine Karoichan, Ling Li, Celine J. Agnes, Bettina M. Willie, Maryam Tabrizian   +4 more
wiley   +1 more source

Smoking in asthma is associated with elevated levels of corticosteroid resistant sputum cytokines—an exploratory study [PDF]

, 2013
<p>Background: Current cigarette smoking is associated with reduced acute responses to corticosteroids and worse clinical outcomes in stable chronic asthma. The mechanism by which current smoking promotes this altered behavior is currently unclear.
A McKay, A Sykes, B Pedersen, Carl de Wet, Charles McSharry, Christopher J. Weir, E Goleva, E Goleva, E Irusen, E Juniper, E Livingston, GJ Zijlstra, GW Chalmers, GW Chalmers, H Kerstjens, J Kam, J St-Laurent, JEM Tomlinson, M Althuis, M Broekema, M Spears, Marco Idzko, Mark Spears, MR Edwards, MR Miller, MR Stämpfli, NC Thomson, Neil C. Thomson, R Chaudhuri, R Chaudhuri, R Crapo, R Meijer, R Sher, Rekha Chaudhuri, S Holgate, SC Lazarus, SE Pedersen, SE Wenzel, WE Naugler, Z Qiu, Z Xing   +40 more
core   +4 more sources