Results 201 to 210 of about 280,561 (284)

Ganoderic Acids Alleviate Dexamethasone‐Induced Muscle Atrophy Potentially via Regulating Protein Synthesis/Degradation, Attenuating Oxidative Stress, and Antagonizing Glucocorticoid Receptor

Phytotherapy Research, EarlyView.
This work proposes a mechanism in which ganoderic acid A (GAA), the active monomer of ganoderic acids (GA) from Ganoderma lucidum, binds to the glucocorticoid receptor (GR) to form a GR‐GAA complex, thereby inhibiting DEX‐induced GR activation. This inhibition suppresses oxidative stress (ROS, MDA and 4‐HNE) by upregulating antioxidant proteins (Nrf2 ...
Kecheng Tang, Yan Yu, Yiru Chen, Zhizhen Huang, Hang Zhang, Yun Tian, Min Li, Yue Yin, Shaowei Li, Bingchuan Liu, Baoxue Yang   +10 more
wiley   +1 more source

The Incidence of Post-Operative Fibrinoid Syndrome in Diabetic Eyes Receiving a Dexamethasone Implant During Pars Plana Vitrectomy Surgery. [PDF]

Clin Ophthalmol
ElSheikh R, Zhang S, Siddiqui MZ, Chauhan MZ, Sallam AB, Uwaydat SH.   +5 more
europepmc   +1 more source

Mogroside V Promotes Brown Adipose Thermogenesis via FTO‐m6A‐LETMD1‐UCP1 Pathway to Combat Obesity

Phytotherapy Research, EarlyView.
Mogroside V (MV) alleviates high‐fat diet‐induced obesity and metabolic dysfunction. Mechanistically, MV suppresses FTO expression, thereby increasing m6A modification of Letmd1 mRNA and enhancing its YTHDC2‐dependent stabilization. Theincreased LETMD1 expression is associated with elevated PGC1α and UCP1 levels, contributing to brown adipocyte ...
Yuan‐hai Sun, Ling‐huan Li, Ya‐qian Feng, Teng‐jiao Zhao, Min‐you Qi, Han‐bing Li   +5 more
wiley   +1 more source

Biomarkers of risk of switching to dexamethasone implant for the treatment of diabetic macular oedema in real clinical practice: a multicentric study. [PDF]

Br J Ophthalmol
Ruiz-Medrano J, Udaondo Mirete P, Fernández-Jiménez M, Asencio-Duran M, Fernández-Vigo JI, Medina-Baena M, Flores-Moreno I, Pareja-Esteban J, Touhami S, Giocanti-Aurégan A, Cicinelli MV, Loewenstein A, Ruiz-Moreno JM.   +12 more
europepmc   +1 more source

Ajugol Improves Liver Fibrosis by Modulating Bile Acid and Arachidonic Acid Metabolism in Mice

Phytotherapy Research, EarlyView.
Ajujol ameliorates hepatic fibrosis by regulating bile acid metabolism and suppressing inflammatory responses. ABSTRACT Ajugol (AJ), the primary component extracted from the root of Rehmannia glutinosa, exhibits protective effects against metabolic dysregulation and chronic inflammation.
Xia Wei, Fangyuan Wang, Dingqi Zhang, Longhui Zhang, Feipeng Xu, Gaofeng Chen, Hua Zhang, Ping Liu, Wei Liu, Ying Xu   +9 more
wiley   +1 more source

Tetrahydroberberine Suppresses Autophagy and Mitigates Doxorubicin‐Induced Ferroptosis in Hepatic Cells via cAMP‐Epac1 Activation

Phytotherapy Research, EarlyView.
THB activates cAMP‐Epac1 signaling to suppress autophagy‐dependent ferroptosis and alleviate DOX‐induced liver injury. ABSTRACT This study investigated the hepatoprotective mechanism of tetrahydroberberine (THB) against doxorubicin (DOX)‐induced liver injury.
Cheng Teng, Mo Chen, Ying Zhao, Song Hu, Linghui Kong, Yan Huang, Shunv Cai, Xiaoyan Zhu, Pengxiang Wang, Pingbo Xu   +9 more
wiley   +1 more source

Subconjunctival dexamethasone implant (Ozurdex^®) in the management of refractory Non-Infectious anterior scleritis. [PDF]

J Ophthalmic Inflamm Infect
Ganbold B, Nguyen BT, Hung JH, Mobasserian A, Thng ZX, Ghoraba H, Yavari N, Feky DE, Yasar C, Saengsirinavin AO, Zhang X, Anover FA, Mohammadi SS, Tuong N, Than T, Khatri A, Elaraby O, Akhavanrezayat A, Gupta AS, Yoo WS, Nguyen QD, Or C.   +21 more
europepmc   +1 more source

An Experimental Study on the Protective Effect of Memantine in Noise‐Induced Hearing Loss

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective This study examined the potential protective effects of memantine, an N‐methyl‐D‐aspartate (NMDA) receptor antagonist, against acoustic trauma (AT) in guinea pigs, using electrophysiological and histopathological analyses. Methods Thirty guinea pigs with normal hearing were divided into six groups (n = 5 per group): Group 1 (control),
Begüm Arda, Selis Gülseven Güven, Erdoğan Bulut, Murat Arslan, Özlem Tuğce Çilingir‐Kaya, Abdullah Taş, Recep Yağız   +6 more
wiley   +1 more source

Intravitreal Dexamethasone Implant (Ozurdex) for Ocular Toxocariasis. [PDF]

J Ophthalmol
Zhou Y, Zhen F, Wu J, Wang S, Lu X, Yang G, Hu Z, Chen F, Li Q, Dong S.   +9 more
europepmc   +1 more source

Inhibin βB Mediates Oligotrophic Adaptation via Regulating Muscle Satellite Cell Proliferation and Differentiation in Schizopygopsis younghusbandi

Integrative Zoology, EarlyView.
① Nutrient deficiency upregulates inhibin βB, activating SMAD signaling to promote p21. Increased p21 inhibits mcm2/mcm4/mcm5 and cyclin E2, inducing G1‐phase arrest, slowing growth, and reducing energy consumption. ② Inhibin βB also upregulates pdgf‐c, which induces α‐SMA, leading to muscle satellite cell fibrosis.
Weiqiang Li, He Gao, Chaowei Zhou, Luo Lei, Junting Li, Chao Ma, Zitu Ma, Mengwei Yao, Kexin Ma, Yunpeng Xiang, Yan Zhou, Yongrui Lu, Da Ji, Minghong Wei, Luohao Xu, Zhaofang Han, Haiping Liu   +16 more
wiley   +1 more source