Results 211 to 220 of about 280,561 (284)

Deficiency of Mitochondrial Fatty Acid Enzyme, CPT1A, Underlies Airway Epithelial Barrier Dysfunction in Severe Asthma

open access: yesAllergy, EarlyView.
Mitochondrial fatty acid enzyme, CPT1A, is deficient in the airway epithelium of severe asthma patients. Restoration of CPT1A expression improved epithelial barrier integrity via increasing mitochondrial respiration and ATP production in airway epithelial cells. Restoration of deficient epithelial CPT1A may represent a new treatment approach for severe
Muyun Wang   +12 more
wiley   +1 more source

Canadian evidence‐based guidelines on spinal procedures for chronic pain

open access: yesAnaesthesia, EarlyView.
Summary Introduction Interventional procedures are commonly used to diagnose and treat chronic pain of spinal origin but guidance on: their indications; frequency; technical conduct; requirements for image guidance; outcome measurement; and management of complications is lacking.
Anuj Bhatia   +26 more
wiley   +1 more source

Adenosine—A Regulator of Human Testicular Peritubular Cells

open access: yesAndrology, EarlyView.
ABSTRACT Background Extracellular purines, in particular ATP and adenosine, are regulators of physiological and pathophysiological processes throughout the human body. Roles in the human testis are emerging and include actions on peritubular cells, which form the wall of seminiferous tubules.
Lina Scholz   +12 more
wiley   +1 more source

Intravitreal Dexamethasone Implant for Patients With Central Retinal Vein Occlusion: Four-Year Outcomes in a Real-World Study. [PDF]

open access: yesCureus
Gkiala A   +7 more
europepmc   +1 more source

Corneal transplantation: Restoring sight to the blind

open access: yesActa Ophthalmologica, EarlyView.
Abstract Corneal blindness is one of the leading causes of vision loss worldwide. Transplantation of the cornea can restore vision and make blind patients see again. Corneal transplant surgery has undergone major evolution in recent decades with the advent of minimally invasive lamellar surgical approaches such as DMEK and DALK.
Claus Cursiefen
wiley   +1 more source

Cancer pain: current practice and emerging targets

open access: yesBritish Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye   +5 more
wiley   +1 more source

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