Results 221 to 230 of about 280,561 (284)

Liver Organoids: From Disease Modelling to Regenerative Medicine

Cell Proliferation, EarlyView.
Liver organoids provide a versatile platform for disease modelling and drug discovery, leveraging stem cells and engineering techniques. They bridge research and clinical applications, offering significant potential for advancing precision medicine and regenerative therapies for liver diseases.
Tiepeng Wang, Xiaotian Qu, Jinhong Si, Junkang Meng, Ting Zhang, Shuliang Niu   +5 more
wiley   +1 more source

Dexamethasone implant in naive versus refractory patients with diabetic macular edema: a Meta-analysis. [PDF]

Int J Ophthalmol
Xu Q, Yang C, Luan J.
europepmc   +1 more source

Chromatin Remodeller BRD9 Orchestrates Odontoblastic Differentiation via Coordinating RUNX2‐KLF4

Cell Proliferation, EarlyView.
During odontoblast lineage commitment, the chromatin remodeller BRD9 acts as a critical epigenetic coordinator, orchestrating the chromatin landscape to facilitate synergistic binding of key transcription factors RUNX2 and KLF4 to target loci for odontogenesis.
Wenrui Zeng, Yuxiu Lin, Yongyan Gao, Delan Huang, Yuanyuan Li, Honglei Ruan, Guohua Yuan, Huan Liu, Zhi Chen   +8 more
wiley   +1 more source

Dexamethasone implant for refractory macular edema secondary to diabetic retinopathy and retinal vein occlusion. [PDF]

Int J Ophthalmol
Zhong YY, Tang C, Zhang LY, Zhang XD, Liu SL.   +4 more
europepmc   +1 more source

Human iPSC‐Derived Vascularised Lung Organoids for Modelling COPD and Pulmonary Hypertension

Cell Proliferation, EarlyView.
Vascularised lung organoids (vLOs) that faithfully mimic human lung tissue architecture and disease pathology are critical for advancing pulmonary research but remain challenging to generate. Here, we developed a robust self‐organisation protocol to produce vLOs with cellular heterogeneity and functional vasculature. The engineered blood vessels within
Simin Jiang, Liangliang Tian, Jingge Qu, Yi Hong, Dian Chen, Zihang Pan, Huanyu Long, Lanhe Chu, Weijing Kong, Qiyang Yao, Xiaojing Ma, Yun Zhao, Baihui Ma, Kai Wang, Yahong Chen   +14 more
wiley   +1 more source

Outcomes of intravitreal dexamethasone implant (Ozurdex^®) in patients with post-surgical macular edema - a real-world scenario. [PDF]

Int J Retina Vitreous
de Oliveira Júnior EO, Ahn I, Fernandes RAB, Fernandes AG.   +3 more
europepmc   +1 more source

Pathological Ossification of Spinal Ligament‐Derived Fibroblasts in an Inflammatory Micro‐Environment via Activation of the ECM/ITGA5/FAK/AKT Pathway in Ankylosing Spondylitis

Cell Proliferation, EarlyView.
Schematic diagram illustrating the activation of the ECM/ITGA5/FAK/AKT axial signalling pathway in the osteogenic transdifferentiation of AS ligaments‐derived fibroblasts and the simulation of ectopic ossification via subcutaneous transplantation in vivo.
Mu Qiao, Kai‐Yang Wang, Chen‐Yu Song, Jing‐Shun Lu, Jiu‐Kun Li, Yong Qiu, Bang‐Ping Qian, Ze‐Zhang Zhu   +7 more
wiley   +1 more source

Should intravitreal dexamethasone implant in refractory diabetic macular edema be used as an adjuvant therapy or switch therapy? [PDF]

Arq Bras Oftalmol
Çakmak S, Demir G, Tunç U, Sukun EY, Akbas YB, Ozkaya A, Artunay O, Erdogan G.   +7 more
europepmc   +1 more source

Adipocyte‐specific NIK depletion enhances energy metabolism and glucose tolerance in mice

The FEBS Journal, EarlyView.
Obesity is associated with reduced energy expenditure and increased hepatic lipid accumulation. This study reveals that loss of NIK in adipocytes stimulates FGF21‐driven expression of thermogenic genes, including UCP1, and mitochondrial uncoupled respiration.
Atakan Ozcan, Caroline Uslucan, Aleyna Kizilyer, Samet Agca, Aylin Karatas, Sanaz Naghizadeh, Bahar Zehra Camurdanoglu Weber, Sukru Anil Dogan, Serkan Kir   +8 more
wiley   +1 more source

Efficacy of Intravitreal Dexamethasone Implant (Ozurdex^®) in Naïve and Refractory Patients with Different Morphological Subtypes of Diabetic Macular Edema. [PDF]

Medicina (Kaunas)
Stavrakas P, Christou EE, Nasikas V, Koutsiouki C, Vakalis A, Asteriadis S, Panos GD, Tranos P.   +7 more
europepmc   +1 more source