Results 1 to 10 of about 69,499 (314)
Dexmedetomidine: present and future directions [PDF]
Korean Journal of Anesthesiology, 2019 Dexmedetomidine is a potent, highly selective α-2 adrenoceptor agonist, with sedative, analgesic, anxiolytic, sympatholytic, and opioid-sparing properties.
Seongheon Lee
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Pakistan Armed Forces Medical Journal, 2023 Objective: To compare the analgesic effect of different routes of Dexmedetomidine when given as an adjuvant to Bupivacaine in the axillary block for surgical correction of radius fracture. Study Design: Quasi-experimental study. Place and Duration
Kaukab Majeed +5 more
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Effect of dexmedetomidine on cardiorespiratory regulation in spontaneously breathing adult rats.
PLoS ONE, 2022 PurposeWe examined the cardiorespiratory effect of dexmedetomidine, an α2- adrenoceptor/imidazoline 1 (I1) receptor agonist, in spontaneously breathing adult rats.MethodsMale rats (226-301 g, n = 49) under isoflurane anesthesia had their tail vein ...
Yoichiro Kitajima +4 more
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Comparison of dexmedetomidine alone or with other sedatives for paediatric sedation during magnetic resonance imaging: a systematic review [PDF]
Medicinski Glasnik, 2023 Aim To compare the outcome of sole dexmedetomidine or with other sedative drugs in paediatric patients during magnetic resonance imaging (MRI). Methods Literature was obtained from PubMed and ScienceDirect from 2010-2020 using key words: sedation ...
Rudy Vitraludyono +2 more
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Intensive Care Medicine Experimental, 2022 Background Sedatives and mild hypothermia alone may yield neuroprotective effects in acute ischemic stroke (AIS). However, the impact of this combination is still under investigation.
Denise Battaglini +12 more
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Frontiers in Aging Neuroscience, 2022 Background: Inflammation promotes the progression of Alzheimer’s disease (AD). In this study, we explored the effect of dexmedetomidine on inflammation and cognitive function in a mouse model of AD.Methods: 5xFAD mice were intragastrically administered ...
Su-mei Luo +8 more
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Journal of Cardiothoracic Surgery, 2020 Background The Surgical Pleth Index (SPI) is a monitoring method that reflects painful stimuli during general anesthesia, and dexmedetomidine is an analgesic adjuvant with an opioid-sparing effect.
Yu-Lan Wang, Xiao-Qi Kong, Fu-Hai Ji
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Journal of International Medical Research, 2022 Objective We investigated the effect of dexmedetomidine anesthesia on postoperative cognitive function after pulmonary surgery. Methods A blinded, prospective, randomized, placebo-controlled study was performed on 60 patients (age range 65–74 years ...
Tao Liu +9 more
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Dexmedetomidine Oral Mucosa Patch for Sedation Suppresses Apoptosis in Hippocampus of Normal Rats [PDF]
International Neurourology Journal, 2017 Purpose Dexmedetomidine, an α2-adrenergic agonist, provides sedative and analgesic effects without significant respiratory depression. Dexmedetomidine has been suggested to have an antiapoptotic effect in response to various brain insults.
Je Hoon Park +9 more
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Safe electrophysiologic profile of dexmedetomidine in different experimental arrhythmia models
Scientific Reports, 2021 Previous studies suggest an impact of dexmedetomidine on cardiac electrophysiology. However, experimental data is sparse. Therefore, purpose of this study was to investigate the influence of dexmedetomidine on different experimental models of ...
Christian Ellermann +9 more
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