Results 1 to 10 of about 68,717 (285)

Effect of dexmedetomidine on cardiorespiratory regulation in spontaneously breathing adult rats.

PLoS ONE, 2022
PurposeWe examined the cardiorespiratory effect of dexmedetomidine, an α2- adrenoceptor/imidazoline 1 (I1) receptor agonist, in spontaneously breathing adult rats.MethodsMale rats (226-301 g, n = 49) under isoflurane anesthesia had their tail vein ...
Yoichiro Kitajima, Nana Sato Hashizume, Chikako Saiki, Ryoji Ide, Toshio Imai   +4 more
doaj   +2 more sources

Dexmedetomidine: present and future directions [PDF]

Korean Journal of Anesthesiology, 2019
Dexmedetomidine is a potent, highly selective α-2 adrenoceptor agonist, with sedative, analgesic, anxiolytic, sympatholytic, and opioid-sparing properties.
Seongheon Lee
doaj   +1 more source

Efficacy of Perineural versus Systemic Dexmedetomidine as an Adjuvant to Bupivacaine for Surgical Anesthesia in Axillary Block

Pakistan Armed Forces Medical Journal, 2023
Objective: To compare the analgesic effect of different routes of Dexmedetomidine when given as an adjuvant to Bupivacaine in the axillary block for surgical correction of radius fracture. Study Design: Quasi-experimental study. Place and Duration
Kaukab Majeed, Amran Hafiz, Usman Eijaz Malik, Fayyaz Hussain, Najm Us Saqib, Amna Gulraz   +5 more
doaj   +1 more source

Mild hypothermia combined with dexmedetomidine reduced brain, lung, and kidney damage in experimental acute focal ischemic stroke

Intensive Care Medicine Experimental, 2022
Background Sedatives and mild hypothermia alone may yield neuroprotective effects in acute ischemic stroke (AIS). However, the impact of this combination is still under investigation.
Denise Battaglini, Adriana Lopes da Silva, Nathane Santanna Felix, Gisele Rodrigues, Mariana Alves Antunes, Nazareth Novaes Rocha, Vera Luiza Capelozzi, Marcelo Marcos Morales, Fernanda Ferreira Cruz, Chiara Robba, Pedro Leme Silva, Paolo Pelosi, Patricia Rieken Macedo Rocco   +12 more
doaj   +1 more source

Dexmedetomidine exerts an anti-inflammatory effect via α2 adrenoceptors to alleviate cognitive dysfunction in 5xFAD mice

Frontiers in Aging Neuroscience, 2022
Background: Inflammation promotes the progression of Alzheimer’s disease (AD). In this study, we explored the effect of dexmedetomidine on inflammation and cognitive function in a mouse model of AD.Methods: 5xFAD mice were intragastrically administered ...
Su-mei Luo, Long-yan Li, Long-yan Li, Li-zhe Guo, Lu Wang, Yan-feng Wang, Na Chen, E. Wang, E. Wang   +8 more
doaj   +1 more source

Comparison of dexmedetomidine alone or with other sedatives for paediatric sedation during magnetic resonance imaging: a systematic review [PDF]

Medicinski Glasnik, 2023
Aim To compare the outcome of sole dexmedetomidine or with other sedative drugs in paediatric patients during magnetic resonance imaging (MRI). Methods Literature was obtained from PubMed and ScienceDirect from 2010-2020 using key words: sedation ...
Rudy Vitraludyono, Arie Utariani, Elizeus Hanindito   +2 more
doaj   +1 more source

Effect of dexmedetomidine on intraoperative Surgical Pleth Index in patients undergoing video-assisted thoracoscopic lung lobectomy

Journal of Cardiothoracic Surgery, 2020
Background The Surgical Pleth Index (SPI) is a monitoring method that reflects painful stimuli during general anesthesia, and dexmedetomidine is an analgesic adjuvant with an opioid-sparing effect.
Yu-Lan Wang, Xiao-Qi Kong, Fu-Hai Ji
doaj   +1 more source

Effect of dexmedetomidine on the Montreal Cognitive Assessment in older patients undergoing pulmonary surgery

Journal of International Medical Research, 2022
Objective We investigated the effect of dexmedetomidine anesthesia on postoperative cognitive function after pulmonary surgery. Methods A blinded, prospective, randomized, placebo-controlled study was performed on 60 patients (age range 65–74 years ...
Tao Liu, Fang-Chao Liu, Yu Xia, Tai-Jun Luo, Fei Wang, Bin Chen, Chun Wang, Guang-Kuo Gao, Wen-Ting Zhai, Wei Liu   +9 more
doaj   +1 more source

Dexmedetomidine Oral Mucosa Patch for Sedation Suppresses Apoptosis in Hippocampus of Normal Rats [PDF]

International Neurourology Journal, 2017
Purpose Dexmedetomidine, an α2-adrenergic agonist, provides sedative and analgesic effects without significant respiratory depression. Dexmedetomidine has been suggested to have an antiapoptotic effect in response to various brain insults.
Je Hoon Park, Il Gyu Ko, Sung Eun Kim, Jun Jang Jin, Lakkyong Hwang, Chang Ju Kim, Soo Hwan Yoon, Jongki Hong, Jun Young Chung, Deok Won Lee   +9 more
doaj   +1 more source

Incidence of acute kidney injury after noncardiac surgery in patients receiving intraoperative dexmedetomidine: a retrospective study

BJA Open, 2023
Background: Postoperative acute kidney injury (AKI) is a common complication and is associated with increased hospital length of stay and 30 day all-cause mortality.
Manuel A. Paredes-Flores, Javier D. Lasala, Teresa Moon, Shreyas Bhavsar, Katherine Hagan, Sarah Huepenbecker, Nicolas P. Carram, Maria F. Ramirez, Kamal Maheswari, Lei Feng, Juan P. Cata   +10 more
doaj   +1 more source