Results 1 to 10 of about 45,743 (196)

Dexmedetomidine: present and future directions [PDF]

Korean Journal of Anesthesiology, 2019
Dexmedetomidine is a potent, highly selective α-2 adrenoceptor agonist, with sedative, analgesic, anxiolytic, sympatholytic, and opioid-sparing properties.
Seongheon Lee
doaj   +2 more sources

The effects of Dexmedetomidine on Recovery from Acute KIdney INjury (DRAIN): a single-center retrospective review using the Medical Information Mart for Intensive Care, fourth edition (MIMIC-IV) [PDF]

Therapeutic Advances in Drug Safety
Background: Dexmedetomidine may expedite recovery from acute kidney injury (AKI) in critically ill adults. Methods: This study utilizes data from the fourth edition of the Medical Information Mart for Intensive Care (MIMIC-IV). Adult patients admitted to
James Harvey Jones, Susannah Fleming
doaj   +2 more sources

Dexmedetomidine enables copper homeostasis in cerebral ischemia/reperfusion via ferredoxin 1

Annals medicus, 2023
Excessive oxygen free radicals and toxic substances are generated in cerebral ischemia-reperfusion (I/R) process. Dexmedetomidine (DEX), a common anesthetic and sedative drug, can considerably boost glutathione (GSH), which has anti-copper influx effects.
Qingduo Guo, Meina Ma, Hongmei Yu, Yuepeng Han, Dong-bo Zhang   +4 more
semanticscholar   +1 more source

Balanced Opioid-free Anesthesia with Dexmedetomidine versus Balanced Anesthesia with Remifentanil for Major or Intermediate Noncardiac Surgery

Anesthesiology, 2021
Background: It is speculated that opioid-free anesthesia may provide adequate pain control while reducing postoperative opioid consumption. However, there is currently no evidence to support the speculation.
H. Beloeil, M. Garot, G. Lebuffe, Alexandre Gerbaud, Julien Bila, P. Cuvillon, Elisabeth Dubout, S. Oger, J. Nadaud, A. Bécret, Nicolas Coullier, Sylvain Lecoeur, Julie Fayon, T. Godet, M. Mazerolles, F. Atallah, S. Sigaut, Pierre-Marie Choinier, K. Asehnoune, A. Roquilly, G. Chanques, M. Esvan, E. Futier, B. Laviolle   +23 more
semanticscholar   +1 more source

Efficacy of Perineural versus Systemic Dexmedetomidine as an Adjuvant to Bupivacaine for Surgical Anesthesia in Axillary Block

Pakistan Armed Forces Medical Journal, 2023
Objective: To compare the analgesic effect of different routes of Dexmedetomidine when given as an adjuvant to Bupivacaine in the axillary block for surgical correction of radius fracture. Study Design: Quasi-experimental study. Place and Duration
Kaukab Majeed, Amran Hafiz, Usman Eijaz Malik, Fayyaz Hussain, Najm Us Saqib, Amna Gulraz   +5 more
doaj   +1 more source

Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis.

New England Journal of Medicine, 2021
BACKGROUND Guidelines currently recommend targeting light sedation with dexmedetomidine or propofol for adults receiving mechanical ventilation. Differences exist between these sedatives in arousability, immunity, and inflammation.
C. Hughes, P. Mailloux, J. Devlin, J. Swan, R. Sanders, A. Anzueto, J. Jackson, Aimee Hoskins, B. Pun, O. Orun, R. Raman, Joanna L. Stollings, A. Kiehl, M. Duprey, Lan N Bui, H. O'Neal, Allison Snyder, M. Gropper, K. Guntupalli, Gregg J. Stashenko, Mayur B. Patel, N. Brummel, T. Girard, R. Dittus, G. Bernard, E. W. Ely, P. Pandharipande   +26 more
semanticscholar   +1 more source

Effect of dexmedetomidine on cardiorespiratory regulation in spontaneously breathing adult rats.

PLoS ONE, 2022
PurposeWe examined the cardiorespiratory effect of dexmedetomidine, an α2- adrenoceptor/imidazoline 1 (I1) receptor agonist, in spontaneously breathing adult rats.MethodsMale rats (226-301 g, n = 49) under isoflurane anesthesia had their tail vein ...
Yoichiro Kitajima, Nana Sato Hashizume, Chikako Saiki, Ryoji Ide, Toshio Imai   +4 more
doaj   +2 more sources

Effect of Sublingual Dexmedetomidine vs Placebo on Acute Agitation Associated With Bipolar Disorder: A Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2022
Importance Acute agitation is common in patients with bipolar disorder and requires urgent management to relieve distress and to prevent escalation to aggressive behavior. Objective To evaluate the effect of orally absorbed, sublingual dexmedetomidine,
S. Preskorn, S. Zeller, L. Citrome, Jeffrey Finman, J. Goldberg, M. Fava, R. Kakar, Michael De Vivo, F. Yocca, R. Risinger   +9 more
semanticscholar   +1 more source

Effect of Intranasal Dexmedetomidine or Midazolam for Premedication on the Occurrence of Respiratory Adverse Events in Children Undergoing Tonsillectomy and Adenoidectomy

JAMA Network Open, 2022
Key Points Question Do preoperative sedatives such as midazolam and dexmedetomidine have a protective effect against perioperative respiratory adverse events (PRAEs) while achieving adequate sedative effect?
Fangming Shen, Qin Zhang, Yahui Xu, Xing-he Wang, Jiayi Xia, Chao Chen, He Liu, Yueying Zhang   +7 more
semanticscholar   +1 more source

Postoperative Delirium after Dexmedetomidine versus Propofol Sedation in Healthy Older Adults Undergoing Orthopedic Lower Limb Surgery with Spinal Anesthesia: A Randomized Controlled Trial

Anesthesiology, 2022
Background: Delirium is a critical postoperative complication in older patients. Based on the hypothesis that intraoperative dexmedetomidine sedation would lower postoperative delirium than propofol sedation would, the authors compared the incidence of ...
Hyun-Jung Shin, Sun Woo Nam, H. Kim, Su-Hoon Yim, Sunghee Han, Jung-Won Hwang, S. Do, H. Na   +7 more
semanticscholar   +1 more source