Results 1 to 10 of about 86,863 (363)

Dexmedetomidine: present and future directions [PDF]

Korean Journal of Anesthesiology, 2019
Dexmedetomidine is a potent, highly selective α-2 adrenoceptor agonist, with sedative, analgesic, anxiolytic, sympatholytic, and opioid-sparing properties.
Seongheon Lee
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Effect of dexmedetomidine on cardiorespiratory regulation in spontaneously breathing adult rats.

PLoS ONE, 2022
PurposeWe examined the cardiorespiratory effect of dexmedetomidine, an α2- adrenoceptor/imidazoline 1 (I1) receptor agonist, in spontaneously breathing adult rats.MethodsMale rats (226-301 g, n = 49) under isoflurane anesthesia had their tail vein ...
Yoichiro Kitajima, Nana Sato Hashizume, Chikako Saiki, Ryoji Ide, Toshio Imai   +4 more
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Efficacy of Perineural versus Systemic Dexmedetomidine as an Adjuvant to Bupivacaine for Surgical Anesthesia in Axillary Block

Pakistan Armed Forces Medical Journal, 2023
Objective: To compare the analgesic effect of different routes of Dexmedetomidine when given as an adjuvant to Bupivacaine in the axillary block for surgical correction of radius fracture. Study Design: Quasi-experimental study. Place and Duration
Kaukab Majeed, Amran Hafiz, Usman Eijaz Malik, Fayyaz Hussain, Najm Us Saqib, Amna Gulraz   +5 more
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Dexmedetomidine exerts an anti-inflammatory effect via α2 adrenoceptors to alleviate cognitive dysfunction in 5xFAD mice

Frontiers in Aging Neuroscience, 2022
Background: Inflammation promotes the progression of Alzheimer’s disease (AD). In this study, we explored the effect of dexmedetomidine on inflammation and cognitive function in a mouse model of AD.Methods: 5xFAD mice were intragastrically administered ...
Su-mei Luo, Long-yan Li, Long-yan Li, Li-zhe Guo, Lu Wang, Yan-feng Wang, Na Chen, E. Wang, E. Wang   +8 more
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Effect of dexmedetomidine on intraoperative Surgical Pleth Index in patients undergoing video-assisted thoracoscopic lung lobectomy

Journal of Cardiothoracic Surgery, 2020
Background The Surgical Pleth Index (SPI) is a monitoring method that reflects painful stimuli during general anesthesia, and dexmedetomidine is an analgesic adjuvant with an opioid-sparing effect.
Yu-Lan Wang, Xiao-Qi Kong, Fu-Hai Ji
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Mild hypothermia combined with dexmedetomidine reduced brain, lung, and kidney damage in experimental acute focal ischemic stroke

Intensive Care Medicine Experimental, 2022
Background Sedatives and mild hypothermia alone may yield neuroprotective effects in acute ischemic stroke (AIS). However, the impact of this combination is still under investigation.
Denise Battaglini, Adriana Lopes da Silva, Nathane Santanna Felix, Gisele Rodrigues, Mariana Alves Antunes, Nazareth Novaes Rocha, Vera Luiza Capelozzi, Marcelo Marcos Morales, Fernanda Ferreira Cruz, Chiara Robba, Pedro Leme Silva, Paolo Pelosi, Patricia Rieken Macedo Rocco   +12 more
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Intraperitoneal Versus Intravenous Dexmedetomidine for Postoperative Analgesia Following Laparoscopic Sleeve Gastrectomy Surgery: A prospective, Randomized Controlled trial

Egyptian Journal of Anaesthesia, 2023
Background Postoperative pain control is a major challenge after laparoscopic sleeve gastrectomy. We conducted this study to evaluate the efficacy of dexmedetomidine either intraperitoneal (IP) or intravenous (IV) as an adjuvant to intraperitoneal ...
Asmaa Fawzy Amer, Tarek Abdel Hay Mostafa, Radwa Fathy Mansour   +2 more
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Clinically relevant concentrations of dexmedetomidine may reduce oxytocin-induced myometrium contractions in pregnant rats [PDF]

Anesthesia and Pain Medicine, 2020
Background Recently, there have been some trials to use dexmedetomidine in the obstetric field but concerns regarding the drug include changes in uterine contractions after labor.
Dong Joon Kim, Young Joon Ki, Bo Hyun Jang, Seongcheol Kim, Sang Hun Kim, Ki Tae Jung   +5 more
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Dexmedetomidine Oral Mucosa Patch for Sedation Suppresses Apoptosis in Hippocampus of Normal Rats [PDF]

International Neurourology Journal, 2017
Purpose Dexmedetomidine, an α2-adrenergic agonist, provides sedative and analgesic effects without significant respiratory depression. Dexmedetomidine has been suggested to have an antiapoptotic effect in response to various brain insults.
Je Hoon Park, Il Gyu Ko, Sung Eun Kim, Jun Jang Jin, Lakkyong Hwang, Chang Ju Kim, Soo Hwan Yoon, Jongki Hong, Jun Young Chung, Deok Won Lee   +9 more
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Safe electrophysiologic profile of dexmedetomidine in different experimental arrhythmia models

Scientific Reports, 2021
Previous studies suggest an impact of dexmedetomidine on cardiac electrophysiology. However, experimental data is sparse. Therefore, purpose of this study was to investigate the influence of dexmedetomidine on different experimental models of ...
Christian Ellermann, Jonas Brandt, Julian Wolfes, Kevin Willy, Felix K. Wegner, Patrick Leitz, Philipp S. Lange, Florian Reinke, Lars Eckardt, Gerrit Frommeyer   +9 more
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