Results 51 to 60 of about 63,586 (320)

The role of dexmedetomidine in neurosurgery

Best Practice & Research Clinical Anaesthesiology, 2021
Dexmedetomidine can be used for sedation and analgesia and has been approved for this use by the European Medicines Agency since 2017. It causes an arousable state of sedation, which is beneficial during neurosurgical procedures that require the patient to cooperate with neurological tests (i.e. tumor surgery or implantation of deep brain stimulators).
S.R. Tasbihgou, C.R.M. Barends, A.R. Absalom   +2 more
openaire   +2 more sources

Association between dexmedetomidine use for the treatment of alcohol withdrawal syndrome and intensive care unit length of stay

Journal of Intensive Care, 2019
Purpose Alcohol withdrawal syndrome (AWS) is commonly treated in medical ICUs and typically requires high resource utilization. Dexmedetomidine for AWS has not been extensively investigated, and guidelines regarding its use are lacking.
Ekaterina R. Yavarovich, Maythawee Bintvihok, Justin C. McCarty, Janis L. Breeze, Peter LaCamera   +4 more
doaj   +1 more source

Dexmedetomidine does not produce vasocontraction on human isolated gastroepiploic artery [PDF]

Korean Journal of Anesthesiology, 2011
BackgroundRecently, the addition of dexmedetomidine to sedation regimens after cardiac surgery had been reported and there is a possibility that dexmedetomidine can cause vasoconstriction.
Won-Sung Kim, Seung-Hoon Baek, Sang Kwon Lee, Tae Yong Jeon, Hee-Young Kim, Sang Wook Shin   +5 more
doaj   +1 more source

Effect of different sedatives on the prognosis of patients with mechanical ventilation: a retrospective cohort study based on MIMIC-IV database

Frontiers in Pharmacology
AimTo compare the effects of midazolam, propofol, and dexmedetomidine monotherapy and combination therapy on the prognosis of intensive care unit (ICU) patients receiving continuous mechanical ventilation (MV).Methods11,491 participants from the Medical ...
Xiaoding Shi, Jiaxing Zhang, Yufei Sun, Meijun Chen, Fei Han   +4 more
doaj   +1 more source

Hypothermia, shivering, and dexmedetomidine [PDF]

Korean Journal of Anesthesiology, 2014
CC Postoperative temperature is increasingly used to indicate the quality of anesthesia. Anesthesiologists should measure and record the body temperature of their patients perioperatively and maintain it within normal limits. Hypothermia is usually defined as a body temperature less than 36 o C and occurs commonly during surgery [1].
openaire   +4 more sources

The Intraoperative Microlesion Effect Positively Correlates With the Short‐Term Clinical Effect of Deep Brain Stimulation in Parkinson's Disease

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objective During the surgical procedure of deep brain stimulation (DBS), insertion of an electrode in the subthalamic nucleus (STN) frequently causes a temporary improvement of motor symptoms, known as the microlesion effect (MLE). The objective of this study was to determine the correlation between the intraoperative MLE and the clinical ...
Stèfan F. Lange, Naomi I. Kremer, Teus van Laar, Fiete Lange, T. Elien Steendam‐Oldekamp, D. L. Marinus Oterdoom, Anthony R. Absalom, J. Marc C. van Dijk, Gea Drost   +8 more
wiley   +1 more source

Age-related effects of dexmedetomidine on myocardial contraction and coronary circulation in isolated guinea pig hearts

Journal of Pharmacological Sciences, 2016
Dexmedetomidine is a selective α2 adrenergic agonist. Although dexmedetomidine is widely used for sedation and analgesia, it frequently produces hypotension and bradycardia.
Maiko Hongo, Susumu Fujisawa, Takeshi Adachi, Tomonori Shimbo, Shigehiro Shibata, Takayoshi Ohba, Kyoichi Ono   +6 more
doaj   +1 more source

Intra‐operative analgesia with remifentanil vs. dexmedetomidine: a systematic review and meta‐analysis with trial sequential analysis

Anaesthesia, 2019
Intra‐operative remifentanil is associated with increased postoperative analgesic requirements and opioid consumption. Dexmedetomidine has characteristics suggesting it may substitute for intra‐operative remifentanil during general anaesthesia, but ...
S. Grape, K. Kirkham, J. Frauenknecht, E. Albrecht   +3 more
semanticscholar   +1 more source

Dexmedetomidine Inhibits Maturation and Function of Human Cord Blood-Derived Dendritic Cells by Interfering with Synthesis and Secretion of IL-12 and IL-23. [PDF]

PLoS ONE, 2016
To investigate the effects and underlying mechanism of dexmedetomidine on the cultured human dendritic cells (DCs).Human DCs and cytotoxic T lymphocytes (CTLs) were obtained from human cord blood mononuclear cells by density gradient centrifugation ...
Gong Chen, Yuan Le, Lei Zhou, Li Gong, Xiaoxiao Li, Yunli Li, Qin Liao, Kaiming Duan, Jianbin Tong, Wen Ouyang   +9 more
doaj   +1 more source

The effect of dexmedetomidine on vasopressor requirements in patients with septic shock: a subgroup analysis of the Sedation Practice in Intensive Care Evaluation [SPICE III] Trial

Critical Care, 2020
Background Septic shock is associated with decreased vasopressor responsiveness. Experimental data suggest that central alpha2-agonists like dexmedetomidine (DEX) increase vasopressor responsiveness and reduce catecholamine requirements in septic shock ...
L. Cioccari, N. Luethi, M. Bailey, Y. Shehabi, B. Howe, A. Messmer, H. Proimos, L. Peck, H. Young, G. Eastwood, T. Merz, J. Takala, S. Jakob, R. Bellomo, Yahya Yaseen Frances Rinaldo Simon Belinda Suhaini Colin Shehabi Arabi Bass Bellomo Erickson Howe Kadiman M, Y. Shehabi, Y. Arabi, F. Bass, R. Bellomo, S. Erickson, B. Howe, S. Kadiman, C. McArthur, L. Murray, M. Reade, I. Seppelt, J. Takala, S. Webb, M. Wise, Y. Arabi, M. Bailey, B. Howe, Lynette J. Murray, Vanessa Singh   +33 more
semanticscholar   +1 more source