Results 51 to 60 of about 68,717 (285)

Dexmedetomidine Prevents Lipopolysaccharide-Induced MicroRNA Expression in the Adult Rat Brain [PDF]

, 2017
During surgery or infection, peripheral inflammation can lead to neuroinflammation, which is associated with cognitive impairment, neurodegeneration, and several neurodegenerative diseases.
Endesfelder, Stefanie, Paeschke, Nadine, Sifringer, Marco, Spies, Claudia D., von Haefen, Clarissa   +4 more
core   +2 more sources

A Virtual Clinical Trial of Psychedelics to Treat Patients With Disorders of Consciousness

Advanced Science, EarlyView.
Disorders of consciousness after severe brain injury are marked by reduced complexity of brain activity and limited treatment options. Using personalized whole‐brain models, this study shows that simulated lysergic acid diethylamide (LSD) and psilocybin shift patient brain dynamics closer to criticality.
Naji L.N. Alnagger, Paolo Cardone, Charlotte Martial, Yonatan Sanz Perl, Iván Mindlin, Jacobo D Sitt, Leor Roseman, Robin Carhart‐Harris, David Nutt, Pablo Mallaroni, Natasha Mason, Johannes G Ramaekers, Vincent Bonhomme, Steven Laureys, Gustavo Deco, Olivia Gosseries, Pablo Núñez, Jitka Annen   +17 more
wiley   +1 more source

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

Dexmedetomidine Inhibits TLR4/NF-κB Activation and Reduces Acute Kidney Injury after Orthotopic Autologous Liver Transplantation in Rats [PDF]

, 2015
published_or_final_versio
Cai, J, Chi, X, Huang, P, Jin, Y, Wang, Y, Wu, S, Xia, Z, Yao, H   +7 more
core   +1 more source

A DNA Tetrahedron Delivery Asiatic Acid to Reprogram Mitochondrial Metabolism for Promoting Bone Regeneration via STAT3 Phosphorylation

Advanced Science, EarlyView.
A hyaluronic acid methacrylate (HAMA) hydrogel incorporating DNA tetrahedrons loaded with Asiatic acid (TDN@AA) was developed. HM‐TDN@AA promotes angiogenesis of endothelial cells (ECs), inhibits osteoclastogenesis from bone marrow–derived macrophages (BMDMs), and enhances osteogenesis of mesenchymal stem cells (MSCs) via STAT3‐mediated mitochondrial ...
Yiwen Huang, Yiming Zhang, Yisheng Feng, Qixiang Yang, Beiyuan Gao, Haiyang Xu, Cheng Huang, Kaili Lin, Yuanzhi Xu, Peiqi Zhu   +9 more
wiley   +1 more source

Clinical effectiveness of a sedation protocol minimizing benzodiazepine infusions and favoring early dexmedetomidine: A before-after study [PDF]

, 2015
INTRODUCTION: Randomized controlled trials suggest clinical outcomes may be improved with dexmedetomidine as compared to benzodiazepines, however further study and validation is needed.
Boyle, Walter A, Drewry, Anne M, Fagley, Richard E, Field, R. Ryan, Kollef, Marin H, Lieu, Angela, Micek, Scott T, Olatunde, Joshua, Skrupky, Lee P, Varghese, Linda, Wessman, Brian   +10 more
core   +2 more sources

Microendovascular Neural Recording from Cortical and Deep Vessels with High Precision and Minimal Invasiveness

Advanced Intelligent Systems, EarlyView.
Intravascular electroencephalography (ivEEG) using micro‐intravascular electrodes was developed. Cortical‐vein ivEEG showed a higher signal‐to‐noise ratio and finer spatial resolution of somatosensory evoked potentials (SEPs) than superior sagittal sinus ivEEG, and deep‐vein ivEEG captured clear visual evoked potentials.
Takamitsu Iwata, Hajime Nakamura, Takafumi Uemura, Teppei Araki, Takaki Matsumura, Takaaki Abe, Toshikazu Nezu, Masatoshi Takagaki, Tomohiko Ozaki, Shinpei Miura, Ryohei Fukuma, Sam E. John, David B. Grayden, Haruhiko Kishima, Tsuyoshi Sekitani, Takufumi Yanagisawa   +15 more
wiley   +1 more source

EEG response of dexmedetomidine during drug induced sleep endoscopy

Frontiers in Neuroscience, 2023
IntroductionDexmedetomidine is one of the anesthetics of choice for drug induced sleep endoscopy (DISE), with advantages including limited respiratory depression, analgesia, and decreased incidence of emergence delirium.
Lichy Han, David R. Drover, Marianne C. Chen, Amit R. Saxena, Sarah L. Eagleman, Vladimir Nekhendzy, Angelica Pritchard, Robson Capasso   +7 more
doaj   +1 more source

Is there a place for dexmedetomidine in equine anaesthesia and analgesia? : a systematic review (2005-2017) [PDF]

, 2018
The objective of this review was to perform a literature compilation of all the equine publications that used dexmedetomidine as the first article on this topic was published, in 2005.
Ambrisko, Ansah, Benmansour, Benmansour, Benmansour, Bettschart-Wolfensberger, Bettschart-Wolfensberger, Bettschart-Wolfensberger, Bettschart-Wolfensberger, De Clercq, Devisscher, Duke-Novakovski, Enderle, Gozalo-Marcilla, Gozalo-Marcilla, Gozalo-Marcilla, Gozalo-Marcilla, Gozalo-Marcilla, Grimsrud, Grimsrud, Grimsrud, Guedes, Hopster, Johnston, Kalchofner, Kharasch, Knych, Kuusela, Lizarraga, Lizarraga, Marcilla, Marcilla, Marly-Voquer, Müller, Pöppel, Ranheim, Rezende, Risberg, Risberg, Sacks, Santos, Savola, Schauvliege, Segal, Taylor, Wojtasiak-Wypart   +45 more
core   +2 more sources

Pharmacologic pitfalls in heart failure: A guide to drugs that may cause or exacerbate heart failure. A European Journal of Heart Failure expert consensus document

European Journal of Heart Failure, EarlyView.
Main categories of harmful drugs in heart failure. CCB, calcium channel blocker; DPP4i, dipeptidyl peptidase‐4 inhibitor; HER2‐TT, human epidermal growth factor receptor 2‐targeted therapy; NSAID, non‐steroidal anti‐inflammatory drug; TKI, tyrosine kinase inhibitor; TZD, thiazolidinedione; VEGF Inh, vascular endothelial growth factor inhibitor.
Amr Abdin, Johann Bauersachs, Magdy Abdelhamid, Suleman Aktaa, Hussam Al Ghorani, Antonio Bayes‐Genis, Jan Biegus, Michael Böhm, Javed Butler, Nicolas Girerd, Marco Metra, Wilfried Mullens, Hadi Skouri, Muthiah Vaduganathan, Seif El Hadidi, Giuseppe M.C. Rosano, Gianluigi Savarese   +16 more
wiley   +1 more source