Results 91 to 100 of about 201,008 (300)

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

Vascularized Liver‐on‐a‐Microsphere Reveals Alanine‐Glucose Metabolism‐Driven Regulation of Liver Function and Injury

Advanced Science, EarlyView.
A vascularized liver‐on‐a‐microsphere system is developed to recreate lobule‐like cellular organization and endothelial barrier function within compartmentalized hydrogel particles. The platform enhances hepatic performance and reveals alanine‐glucose cycle activation linked to improved detoxification capacity, offering a high‐throughput microscale ...
Jingyang Li, Zengnan Wu, Yingrui Zhang, Shulang Chen, Yongning Lin, Shiyu Chen, Tong Xu, Xianli Meng, Yi Zhang, Jin‐Ming Lin   +9 more
wiley   +1 more source

Preparation and characterization of magnetite/dextran nanocomposite used as a precursor of magnetic fluid

, 2009
Magnetic nanoparticles were synthesized by the co-precipitation of Fe(2+) and Fe(3+) using ammonium hydroxide (NH(4)OH). The obtained nanoparticles were characterized by X-ray powder diffraction.
Li, J. H., Qu, J. M., Hong, R. Y., Hong, RY, Li, H. Z., Chen, L. L.   +5 more
core   +1 more source

Prebiotic and Health-Promoting Benefits of Dextran-Type Exopolysaccharide Produced by Leuconostoc mesenteroides SJC113

Foods
The exopolysaccharide (EPS) produced by Leuconostoc mesenteroides SJC113 is a glucan with α-1,6 and α-3,6 branched glycosidic linkages that may promote human health.
Dominika Jurášková, Susana C. Ribeiro, Célia C. G. Silva   +2 more
doaj   +1 more source

S100A8/A9‐High Macrophages Activate Intestinal Fibroblasts via mCCL6/hCCL15‐CCR1 Axis to Drive Intestinal Fibrosis in Crohn's Disease

Advanced Science, EarlyView.
S100A8/A9‐high macrophages are markedly enriched in the stenotic intestinal tissue of patients with Crohn's disease. These profibrotic macrophages secrete mCCL6 in a STAT3‐dependent manner. mCCL6 and its human ortholog hCCL15 activate fibroblasts via the CCR1 receptor, thereby driving excessive collagen deposition.
Shu Wang, Jiayun Wang, Junjie Lin, Ziping Ye, Geyujia Zhou, Jingjing Ma, Junjian Sun, Jiang Yu, Yingdi Zhang, Nana Tang, Chunhua Jiao, Xiaojing Zhao, Hongjie Zhang   +12 more
wiley   +1 more source

Novel supermacroporous dextran gels

, 2006
Supermacroporous dextran gels (SDGs), having pores tens of micrometers in size and highly interconnected, were prepared from dextran macromonomer through radical polymerization at subzero temperatures and compared with dextran gels prepared at ambient ...
Galaev, Igor, Mattiasson, Bo, Oknianska, Alina,, Degerman, Eva,, Plieva, Fatima, Lund University., Oknianska, Alina, Degerman, Eva   +7 more
core   +1 more source

pH-Responsive Modified Dextran Nanogel for Liver Targeted Doxorubicin Delivery

Gels
A key obstacle to the efficacy of cancer drugs is the safe delivery of the drugs to the target site of the disease. Recent advances in nanomedicine have introduced smart hydrogel nanoparticles as promising, efficient, secure, and stimulus-responsive drug
Amin Raeisi, Mohammad Doroudian, Banafsheh Rastegari, Soliman Mohammadi-Samani, Abbas Behzad-Behbahani, Fatemeh Farjadian   +5 more
doaj   +1 more source

Targeting p21‐High Senescent Kupffer Cells Nanotherapeutically Potentiates Antitumor Immunity in Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

Advanced Science, EarlyView.
Schematic illustration of a biomimetic SKEV@AAV platform targeting p21‐high senescent Kupffer cells (sKCs) in hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). p21‐high sKCs accumulate in the PVTT microenvironment and establish an immunosuppressive, SASP‐rich environment that facilitates tumor cell proliferation and immune evasion.
Na Ta, Shuyi Wang, Boyan Zhang, Ning Liu, Yingchen Han, Aoran Liu, Ying Xu, Tingsong Chen, Ye Zhang, Qiuhua Luo, Tao Han   +10 more
wiley   +1 more source

Dextran sulfate enhances the level of an oxidative DNA damage biomarker, 8-oxo-7,8-dihydro-2 0-deoxyguanosine, in rat colonic mucosa [PDF]

, 1998
Dextran sodium sulfate (DSS) given in drinking water can induce colonic Inflammation and produce colorectal tumors in rodents, although it is not directly genotoxic.
Petit, Claude, Embvani, E., Jaeg, Jean-Philippe, Tardieu, Didier, Corpet, Denis E., Cadet, Jean   +5 more
core  

Exploring Exopolysaccharides Produced in Indigenous Mexican Fermented Beverages and Their Biotechnological Applications

Fermentation
Indigenous Mexican fermented beverages, such as pulque, colonche, tepache, and water kefir, are pillars of the country’s cultural and gastronomic heritage.
Julián Fernando Oviedo-León, Abril Ramírez Higuera, Jorge Yáñez-Fernández, Humberto Hernández-Sánchez, Diana C. Castro-Rodríguez   +4 more
doaj   +1 more source