Results 181 to 190 of about 280,112 (279)

Piperazine‐Functionalized Nanoparticles Enable Oral Insulin Delivery in Obese Mice

Advanced Science, EarlyView.
ABSTRACT Biologics have gained prominence as a rapidly advancing therapeutic modality for a diverse spectrum of medical conditions. Nonetheless, they are predominantly administered parenterally due to poor absorption through the gastrointestinal tract. Additionally, repeated injections of biologics such as insulin cause injection pain, leading to dose ...
Yuxue Cao, Xiaofan Jiang, Md Moniruzzaman, Alexandra Mueller, Taskeen Iqbal Janjua, Nisha Tyagi, Zhi Qu, Kuan Yau Wong, Yuran Feng, Aayushi Ghodasara, Ekaterina Strounina, Benjamin P. Ross, Tushar Kumeria, Sumaira Z. Hasnain, Amirali Popat   +14 more
wiley   +1 more source

Vector-free DNA transfection by nuclear envelope mechanoporation.

Lab Chip
Akh L, Fajrial AK, Sohn S, Seelbinder B, Xu X, Tan W, Slansky JE, Neu CP, Ding X.   +8 more
europepmc   +1 more source

Triple Endoscopic Hemostatic Therapy for Life Threatening Duodenal Variceal Bleed. [PDF]

ACG Case Rep J
Hamarsheh S, Khalid MU, Siddiki H.
europepmc   +1 more source

Loss of VMP1 Impairs Tight Junction Recycling and Aggravates Intestinal Barrier Dysfunction in Inflammatory Bowel Disease

Advanced Science, EarlyView.
This study identifies vacuole membrane protein 1 (VMP1) as a critical regulator of intestinal epithelial barrier homeostasis. VMP1 facilitates the recruitment of CORO1C to late endosomes, supporting Retromer‐mediated recycling of the tight junction protein Occludin.
Jiawei Zhao, Jianjun Zou, Chen Zhou, Yingui Wang, Yiman Liu, Yanqing Zhou, Yuxiang Wang, Xinyu Zhang, Huishu Yang, Hongjie Yin, Dongsheng Bai, Yue Zhao, Na Lu   +12 more
wiley   +1 more source

Chitosan-dextran sulfate nanocapsules for enhanced tigecycline efficacy against non-typhoidal Salmonella enterica. [PDF]

Sci Rep
Omar MR, Saeed AA, Malhat SM, El-Sayed AA, Ali AA, Youssef CRB, Tartor YH.   +6 more
europepmc   +1 more source

Extracellular Vesicles in Autoimmune Diseases: From Diagnostic Biomarkers to Engineered Therapeutics

Advanced Science, EarlyView.
This review provides a systematic comparison of extracellular vesicles (EVs) from both mammalian and plant sources in the context of autoimmune diseases. It highlights their emerging roles as precision biomarkers and engineered therapeutic platforms.
Yufei Wu, Huiyuan Ma, Tinghui Zhu, Shuwei Huang, Manxi Lu, Qiong Wang, Zai‐Long Chi   +6 more
wiley   +1 more source

Effect of Garambullo (Myrtillocactus geometrizans) Consumption on the Intestinal Microbiota Profile in an Early-Phase Rat Model of Colon Cancer. [PDF]

Int J Mol Sci
Sánchez-Recillas E, Almanza-Aguilera E, Bars-Cortina D, Zamora-Ros R, Godínez-Santillán RI, Sánchez-Tusié AA, Vergara-Castañeda HA.   +6 more
europepmc   +1 more source

Overexpression of alpha(1)-acid glycoprotein in transgenic mice leads to sensitisation to acute colitis. [PDF]

, 2002
BAUMANN, H, BERGER, FG, Brouckaert, Peter, Hochepied, Tino, Libert, Claude, Steidler, Lothar, Wullaert, Andy   +6 more
core   +2 more sources

TrxR2 Lactylation Facilitates Mitochondrial Protection and Endothelial Ferroptosis Resistance in Diabetic Cardiomyopathy

Advanced Science, EarlyView.
TrxR2 deletion in diabetic mice suppresses TUFM‐AMPK‐FUNDC1‐dependent mitophagy in endothelial cells, resulting in SCP2 upregulation and mitochondrial translocation of ACSL4. Mitochondrial ACSL4 promotes mitochondrial eicosanoid biosynthesis and ferroptosis, thereby aggravating cardiac microvascular injury and diabetic cardiomyopathy.
Su Li, Muyin Liu, Chao Chen, Xinyan Li, Xiaopei Yan, Wentao Zhu, Wenyan Qiu, Qiyu Li, Xiangyu Sun, Chao Huang, Ming Yin, Zhangwei Chen, Yao Lu, Junbo Ge, Xiangqing Kong, Juying Qian, Yuqiong Chen   +16 more
wiley   +1 more source

Parallel Morphological and Functional Development in the Xenopus Retinotectal System. [PDF]

Dev Neurobiol
Li VJ, Foubert D, Schohl A, Ruthazer ES.
europepmc   +1 more source