Results 181 to 190 of about 78,284 (308)

Gasdermin‐Mediated Pyroptosis: Novel Strategies Against Colorectal Cancer

Cancer Science, EarlyView.
Pyroptosis is a double‐edged sword in colorectal cancer (CRC): chronic low‐grade pyroptosis promotes tumor progression, whereas acute induction of pyroptosis in cancer cells triggers antitumor immunity and enhances therapeutic response. Targeting gasdermin‐mediated pyroptosis represents a promising strategy for CRC treatment.
Kaibo Guo, Yuqian Feng, Jiamin Lu, Nuerbiye Abudurexiti, Xinlei Zhou, Mengfan Wei, Song Zheng   +6 more
wiley   +1 more source

Copper chelator ammonium tetrathiomolybdate ameliorates the visceral hypersensitivity in dextran sulfate sodium-induced colitis mice. [PDF]

Mol Pain
Gao L, Wang R, Zhou J, Xu S, Feng S, Zhao L, Jiang C, Wang X.   +7 more
europepmc   +1 more source

Multinucleation of macrophages with dextran sulfate in vitro.

Agricultural and Biological Chemistry, 1991
SORIMACHI, Kenji, AKIMOTO, Kazumi, YAMAZAKI, Sunao, TODA, Shozo, NIWA, Akira, YASUMURA, Yosihiro   +5 more
openaire   +3 more sources

Repeated Dextran Sulfate Sodium Exposure Elicits Distinct Immune Responses Reflecting Human Ulcerative Colitis. [PDF]

Cell Mol Gastroenterol Hepatol
Manzanares LD, Dehghani Z, Herrnreiter CJ, Ren X, Sumagin ME, Serdiukova A, Naqib A, Green S, Wechsler JB, Sumagin R.   +9 more
europepmc   +1 more source

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

Cell Proliferation, EarlyView.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao, Lin Qi, Guijun Zou, Xingpeng Yang, Yizhao Ma, Zhifu Li, Xiaohui Du, Pengyue Zhao   +7 more
wiley   +1 more source

Synergistic effects of fecal microbiota transplantation and andrographolide on gut microbiota modulation in dextran sulfate sodium-induced colitis in mice. [PDF]

Front Microbiol
Luo X, Feng J, Sun Y, Tan Z, Wang L, Bao Y, Lu J, He J, Lu B.   +8 more
europepmc   +1 more source

PEG400 regulates Falcipain 2 activity through an allosteric mechanism

The FEBS Journal, EarlyView.
Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath, Subhoja Chakraborty, Sampa Biswas   +2 more
wiley   +1 more source

Compound spleen-tonifying composition alleviates dextran sulfate sodium-induced ulcerative colitis in rats. [PDF]

World J Gastrointest Surg
Zhao WC, Zhao QL, Zhang Y, Zhao N, Tian JQ, Wu YY, Zhang W.   +6 more
europepmc   +1 more source

Endodontic Treatment of Apical Periodontitis Mitigates Systemic Inflammation and Restores the Blood–Brain Barrier Integrity in an In Vitro Model

International Endodontic Journal, EarlyView.
ABSTRACT Aim A growing body of research supports an association between periapical inflammation and an increased risk of various systemic effects. However, there is currently no scientific evidence demonstrating a causal relationship between this inflammation and changes in epithelial or endothelial permeability in patients with apical periodontitis ...
Loredana Bergandi, Mario Alovisi, Elena Tachis, Nicola Scotti, Andrea Baldi, Iris Chiara Salaroglio, Sabrina Digiovanni, Lorena Charrier, Francesca Silvagno, Damiano Pasqualini   +9 more
wiley   +1 more source

Daikenchuto ameliorates dextran sulfate sodium-induced acute and chronic ulcerative colitis by regulating gut microbiota-derived indoles to activate AhR signaling. [PDF]

Chin Med
Liang R, Liu X, Chen Q, Zhang M, Xu Y, Shi H, Wang S, Jing W.   +7 more
europepmc   +1 more source