Results 21 to 30 of about 10,000 (254)

BINDING OF PIPRINHYDRINATE TO PLASMA PROTEINS AND THEIR SUBSTITUTES [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University, 1994
The binding of piprinhydrinate to bovine serum albumin (BSA) was studied in isotonic Sorensen's phosphate buffer pH 7.4 at 25±1°C, using equilibrium dialysis technique.
M. Abd ElRahman, B. Müller, S. Abu-Zaid, F. Gazy, M. Mohamed   +4 more
doaj   +1 more source

Formation of nanoparticles by cooperative inclusion between (S)-camptothecin-modified dextrans and β-cyclodextrin polymers

Beilstein Journal of Organic Chemistry, 2015
Novel (S)-camptothecin–dextran polymers were obtained by “click” grafting of azide-modified (S)-camptothecin and alkyne-modified dextrans. Two series based on 10 kDa and 70 kDa dextrans were prepared with a degree of substitution of (S)-camptothecin ...
Thorbjørn Terndrup Nielsen, Catherine Amiel, Laurent Duroux, Kim Lambertsen Larsen, Lars Wagner Städe, Reinhard Wimmer, Véronique Wintgens   +6 more
doaj   +1 more source

Gold Nanoparticle-Mediated Photoporation Enables Delivery of Macromolecules over a Wide Range of Molecular Weights in Human CD4+ T Cells

Crystals, 2019
The modification of CD4+ T cells with exogenous nucleic acids or proteins is a critical step in several research and therapeutic applications, such as HIV studies and cancer immunotherapies.
Laurens Raes, Clarissa Van Hecke, Julie Michiels, Stephan Stremersch, Juan C. Fraire, Toon Brans, Ranhua Xiong, Stefaan De Smedt, Linos Vandekerckhove, Koen Raemdonck, Kevin Braeckmans   +10 more
doaj   +1 more source

Inducing an LCST in hydrophilic polysaccharides via engineered macromolecular hydrophobicity

Scientific Reports, 2023
Thermoresponsive polysaccharide-based materials with tunable transition temperatures regulating phase-separated microdomains offer substantial opportunities in tissue engineering and biomedical applications.
Saniya Yesmin Bubli, Matthew Smolag, Ellen Blackwell, Yung-Chun Lin, John G. Tsavalas, Linqing Li   +5 more
doaj   +1 more source

Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma

eLife, 2017
Transport of solutes through brain involves diffusion and convection. The importance of convective flow in the subarachnoid and paravascular spaces has long been recognized; a recently proposed ‘glymphatic’ clearance mechanism additionally suggests that ...
Alex J Smith, Xiaoming Yao, James A Dix, Byung-Ju Jin, Alan S Verkman   +4 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Large molecules from the cerebrospinal fluid enter the optic nerve but not the retina of mice

Fluids and Barriers of the CNS
It has been proposed that cerebrospinal fluid (CSF) can enter and leave the retina and optic nerve along perivascular spaces surrounding the central retinal vessels as part of an aquaporin-4 (AQP4) dependent ocular ‘glymphatic’ system.
Xiao J. Tong, Gokhan Akdemir, Meetu Wadhwa, Alan S. Verkman, Alex J. Smith   +4 more
doaj   +1 more source

Transdermal delivery of FITC-Dextrans with different molecular weights using radiofrequency microporation

Biomaterials Research, 2020
Background Transdermal delivery is of great importance for the effective delivery of bioactive or therapeutic agents into a body. The microporation device based on radiofrequency can be used to enhance delivery efficiency by removing the epidermis layer.
Guk Young Ahn, Hae-Seok Eo, Dongwon Kim, Sung-Wook Choi   +3 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Doxorubicin increases permeability of murine small intestinal epithelium and cultured T84 monolayers

Scientific Reports, 2020
Enteric bacteria and/or their products are necessary for doxorubicin (DXR)-induced small intestine mucosal damage. While DXR does not induce gross loss of epithelium, others have shown elevated serum endotoxin after DXR administration.
Paul Cray, Breanna J. Sheahan, Jocsa E. Cortes, Christopher M. Dekaney   +3 more
doaj   +1 more source