A2A Adenosine Receptor Antagonism Reverts the Blood-Brain Barrier Dysfunction Induced by Sleep Restriction. [PDF]
PLoS ONE, 2016 Chronic sleep restriction induces blood-brain barrier disruption and increases pro-inflammatory mediators in rodents. Those inflammatory mediators may modulate the blood-brain barrier and constitute a link between sleep loss and blood-brain barrier ...
Gabriela Hurtado-Alvarado +3 more
doaj +1 more source
Sizing nanomaterials in bio-fluids by cFRAP enables protein aggregation measurements and diagnosis of bio-barrier permeability [PDF]
, 2016 Sizing nanomaterials in complex biological fluids, such as blood, remains a great challenge in spite of its importance for a wide range of biomedical applications. In drug delivery, for instance, it is essential that aggregation of protein-based drugs is
Braeckmans, Kevin +8 more
core +2 more sources
Delivery of mixed-lineage kinase domain-like protein by vapor nanobubble photoporation induces necroptotic-like cell death in tumor cells [PDF]
, 2019 Modern molecular medicine demands techniques to efficiently deliver molecules directly into mammalian cells. As proteins are the final mediators of most cellular pathways, efficient intracellular protein delivery techniques are highly desired.
Braeckmans, Kevin +10 more
core +2 more sources
Uptake of macromolecules by cercariae during skin penetration and transformation to schistosomula (Schistosoma mansoni) [PDF]
, 2010 Here, we observed the uptake of membrane-impermeant molecules by cercariae as they penetrate the skin and are transformed into schistosomula. We propose that membrane-impermeant molecules, Lucifer Yellow, Propidium iodide and Hoechst 33258 enter the ...
Alvisi de Oliviera, Fabricia +7 more
core +4 more sources
Fluids and Barriers of the CNS, 2012 Background Convection-enhanced delivery (CED), a direct method for drug delivery to the brain through intraparenchymal microcatheters, is a promising strategy for intracerebral pharmacological therapy.
Barua Neil U +6 more
doaj +1 more source
Veins and Lymphatics, 2022 INTRODUCTION: The blood-brain barrier (BBB) is compromised in multiple central nervous system (CNS) disorders associated with neuroinflammation, including multiple sclerosis (MS).
Wenshen Wang +3 more
doaj +1 more source
Calibration of ultrafiltration membranes against size exclusion chromatography columns [PDF]
, 2010 Using the extension of the concept of universal calibration parameter, yielding a relation between the hydrodynamic volume of molecules and the elution volume in sizeexclusionchromatography (SEC), to retention coefficients in ultrafiltration (UF), we ...
Aimar, Pierre, Meireles, Martine
core +2 more sources
Dextran dextrinase and dextran of Gluconobacter oxydans
Journal of Industrial Microbiology & Biotechnology, 2005 Certain strains of Gluconobacter oxydans have been known since the 1940s to produce the enzyme dextran dextrinase (DDase; EC2.4.1.2)-a transglucosidase converting maltodextrins into (oligo)dextran. The enzyme catalyses the transfer of an alpha1,4 linked glucosyl unit from a donor to an acceptor molecule, forming an alpha1,6 linkage: consecutive ...
Myriam, Naessens +3 more
openaire +2 more sources
Dextranas em açúcares do estado de São Paulo Dextrans in lugars from São Paulo State
Química Nova, 2008 The characterization of dextran in sugars by size exclusion chromatography (SEC) has been carried out according to the number-average molecular weight (Mn), the weight-average molecular weight (Mw), the Z-average molecular weight (Mz), and the ...
Francisco Wendel Batista de Aquino +1 more
doaj +1 more source
Differential effects on membrane permeability and viability of human keratinocyte cells undergoing very low intensity megasonic fields [PDF]
, 2017 Among different therapeutic applications of Ultrasound (US), transient membrane sonoporation (SP) - a temporary, non-lethal porosity, mechanically induced in cell membranes through US exposure - represents a compelling opportunity towards an efficient ...
Bedini, A +11 more
core +1 more source