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Cytosolic Uptake of Large Monofunctionalized Dextrans
Dextrans are a versatile class of polysaccharides with applications that span medicine, cell biology, food science, and consumer goods. Here, we report on a new type of large monofunctionalized dextran that exhibits unusual properties: efficient ...
Henry R. Kilgore (3917024) +2 more
core +1 more source
Influence of ultrafiltration membrane characteristics on adsorptive fouling with dextrans [PDF]
This paper presents a detailed investigation of fouling mechanisms for ultrafiltration membranes with polysaccharides obtained by studying membrane–solute (static adsorption) and membrane–solute–solute interactions (ultrafiltration (UF)).
Ulbricht, M., Susanto, H.
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The modification of CD4+ T cells with exogenous nucleic acids or proteins is a critical step in several research and therapeutic applications, such as HIV studies and cancer immunotherapies.
Laurens Raes +10 more
doaj +1 more source
Inducing an LCST in hydrophilic polysaccharides via engineered macromolecular hydrophobicity
Thermoresponsive polysaccharide-based materials with tunable transition temperatures regulating phase-separated microdomains offer substantial opportunities in tissue engineering and biomedical applications.
Saniya Yesmin Bubli +5 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Large molecules from the cerebrospinal fluid enter the optic nerve but not the retina of mice
It has been proposed that cerebrospinal fluid (CSF) can enter and leave the retina and optic nerve along perivascular spaces surrounding the central retinal vessels as part of an aquaporin-4 (AQP4) dependent ocular ‘glymphatic’ system.
Xiao J. Tong +4 more
doaj +1 more source
Background Transdermal delivery is of great importance for the effective delivery of bioactive or therapeutic agents into a body. The microporation device based on radiofrequency can be used to enhance delivery efficiency by removing the epidermis layer.
Guk Young Ahn +3 more
doaj +1 more source
STRUCTURAL STUDIES ON CLINICAL DEXTRANS: PART 1. METHYLATION AND PERIODATE OXIDATION STUDIES
Determinations have been made of the structures of four clinical dextrans, i.e. partially depolymerized dextrans which, in solution, are used as blood-volume expanders.
K. C. B. Wilkie, J. K. N. Jones
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High and Low Molecular Weight Fluorescein Isothiocyanate (FITC)–Dextrans to Assess Blood-Brain Barrier Disruption: Technical Considerations [PDF]
This note is to report how histological preparation techniques influence the extravasation pattern of the different molecular sizes of fluorescein isothiocyanate (FITC)-dextrans, typically used as markers for blood-brain barrier leakage.
Jörg Bredno +11 more
core +1 more source
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source

