Results 41 to 50 of about 10,000 (254)

Biodegradable and Biocompatible Functional Polymers for Biomedical Applications

Advanced Functional Materials, EarlyView.
Biodegradable and biocompatible functional polymers integrate electrical, mechanical, and stimuli‐responsive functionalities while enabling programmed degradation under physiological conditions. This review introduces recent advances in conductive, shape‐memory, self‐healing, photocurable, and adhesive polymer systems, emphasizing material design ...
Won Bae Han, Shuvra Mondal, Sungkeun Han, Chan‐Hwi Eom, Venkata Ramesh Naganaboina, Suk‐Won Hwang   +5 more
wiley   +1 more source

Chromatographic Separation of Isomaltooligosaccharides on Ion-Exchange Resins: Effect of the Cationic Form

Adsorption Science & Technology, 2012
Prebiotic isomaltooligosaccharides (IMOs) are composed of α-d-glucose units linked by glucosidic α (1Ø6) bonds and they remain intact until reaching the large bowels, where they are metabolized by bifidobacteria and lactobacillus.
M.C. Rabelo, C.S.M. Pereira, S. Rodrigues, A.E. Rodrigues, D.C.S. Azevedo   +4 more
doaj   +1 more source

Tuning Mechanoreceptor Signaling Enhances the Adjuvant Effect of Biomaterial Vaccines

Advanced Functional Materials, EarlyView.
Matrix stiffness serves as an independent immunological signal in biomaterial vaccines. Stiffer microporous hydrogel vaccines enhance dendritic cell maturation and migration to draining lymph nodes, promote T follicular helper cell expansion through Yap/Taz signaling, and increase antigen‐specific antibody production.
Lily Shang, Daniel P. Mayer, Prabhat K. Purbey, Yingzi Liu, Kindra Kelly‐Scumpia, Clara Kang, Natalie Tsubamoto, Dhriti Bolangadi, Iqra Arshad, Charisse Ng, Maksim V. Plikus, Dino Di Carlo, Jason S. Weinstein, Philip O. Scumpia   +13 more
wiley   +1 more source

Nanofiber‐Supported Decellularized Matrix Membrane Creates a Biomimetic Biochemical and Biophysical Niche for Intestinal Organoid Epithelium

Advanced Healthcare Materials, EarlyView.
A nanofiber‐supported decellularized extracellular matrix (NaDE) membrane recreates key biochemical and mechanical features of native intestinal tissue. This platform enables the formation of a more physiologically relevant intestinal epithelium, enhancing stem cell maintenance and promoting diverse cell differentiation.
Jaeseung Youn, Hyeonji Kim, Nam Than, Juhyeok Kim, Jangwon Yoon, Dohui Kim, Hyun Jung Kim, Dong Sung Kim   +7 more
wiley   +1 more source

Methodological aspects of determining molecular mass distribution of dextrans by size-exclusion chromatography for various groups of medicines

Регуляторные исследования и экспертиза лекарственных средств, 2018
The article analyses the results of quality evaluation of dextran substances and medicines produced thereof which was carried out by the Institution as part of pre-authorisation testing and involved the analysis of the «molecular mass distribution ...
R. S. Smirnov, E. V. Ivanainen, A. I. Lutseva, O. A. Vaganova, D. A. Orlov   +4 more
doaj  

Nanoplatforms for Sentinel and Tumor‐Draining Lymph Node Mapping: From Visualization to Pathway‐Informed Staging

Advanced Healthcare Materials, EarlyView.
Lymphotropic nanoplatforms integrate multimodal imaging with therapeutic guidance to map sentinel and tumor‐draining lymph nodes, revealing functional drainage, metastatic involvement, and nodal accessibility, while providing mechanistic insight to support precision surgical and therapeutic interventions.
Xu Chen, Nina Li, Meiyan Zou, Zihao Zhou, Rongwei Xu, Weiyao Feng, Xinyuan Zhao, Li Cui   +7 more
wiley   +1 more source

A Novel Method to Image Macropinocytosis in Vivo

Frontiers in Neuroscience, 2018
Here we described an experimental protocol for in vivo imaging of macropinocytosis and subsequent intracellular events. By microinjection, we delivered fluorescence dextrans together with or without ATPγS into transparent Drosophila melanogaster embryos.
Lunhao Chen, Lunhao Chen, Daxiao Cheng, Jiachen Chu, Jiachen Chu, Ting Zhang, Zhuoer Dong, Huifang Lou, Liya Zhu, Yijun Liu   +9 more
doaj   +1 more source

A Novel Perfused Full‐Thickness Human Skin Microphysiological System for Modeling Injury, Regeneration, Tumor Pathophysiology, and Therapeutics Development

Advanced Healthcare Materials, EarlyView.
What if human skin could remain fully alive and functional outside the body for weeks? A New Alternative Method (NAM) based on a vascularized full‐thickness skin microphysiological system achieves precisely this, preserving native vasculature, resident immunity, and metabolic activity for up to three weeks, while faithfully recapitulating radiation ...
Yusuf Surucu, Hamid Malekzadeh, Alexa Rivera Del Rio Hernandez, Naresh Mahajan, Ethan Banks, Dayyan Ur Rahman, José A. Arellano, Katherine S. Yang, Alexey Altman, G.V. Naveen Kumar, Matthew L. Steinhauser, Jeffrey A. Gusenoff, J. Peter Rubin, Asim Ejaz   +13 more
wiley   +1 more source

Altered Nrf2 signaling mediates hypoglycemia-induced blood-brain barrier endothelial dysfunction in vitro.

PLoS ONE, 2015
Hypoglycemia impairs blood-brain barrier (BBB) endothelial function; a major hallmark in the pathogenesis of various CNS disorders. Previously, we have demonstrated that prolonged hypoglycemic exposure down-regulated BBB endothelial NF-E2 related factor ...
Ravi K Sajja, Kayla N Green, Luca Cucullo   +2 more
doaj   +1 more source

INTERACTION OF DIMETHINDENE MALEATE WITH BOVINE SERUM ALBUMIN AND PLASMA SUBSTITUTES

Zagazig Journal of Pharmaceutical Sciences, 1994
Binding of dimethindene maleate to bovine serum albumin (BSA) was studied in isotonic Sorensen's phosphate buffer of pH 7.4 at 25°C, using equilibrium dialysis technique.
Bernd Muller , Mohamed Salama , Fakhredin Ghazy , Samir Abu-Zaid , Mohamed Abd El-Rahman   +4 more
doaj   +1 more source