Results 61 to 70 of about 38,524 (332)

Blood-brain barrier disruption in CCL2 transgenic mice during pertussis toxin-induced brain inflammation [PDF]

, 2012
BACKGROUND: The chemokine CCL2 has an important role in the recruitment of inflammatory cells into the central nervous system (CNS). A transgenic mouse model that overexpresses CCL2 in the CNS shows an accumulation of leukocytes within the perivascular ...
Buist, Richard, Del Bigio, Marc R, Khorooshi, Reza, Owens, Trevor, Peeling, James, Schellenberg, Angela E, Toft-Hansen, Henrik   +6 more
core   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Effect of crowding by dextrans on the hydrolysis of N-Succinyl-L-phenyl-Ala-p-nitroanilide catalyzed by α-chymotrypsin [PDF]

, 2017
Traditionally, studies on the diffusion-controlled reaction of biological macromolecules have been carried out in dilute solutions (in vitro). However, in an intracellular environment (in vivo), there is a high concentration of macromolecules, which ...
Cascante i Serratosa, Marta, Garcés, Josep Lluís, Madurga Díez, Sergio, Mas i Pujadas, Francesc, Pastor, Isabel, Vilaseca i Font, Eudald   +5 more
core   +1 more source

Patterning the Void: Combining L‐Systems with Archimedean Tessellations as a Perspective for Tissue Engineering Scaffolds

Advanced Functional Materials, EarlyView.
This study introduces a novel multi‐scale scaffold design using L‐fractals arranged in Archimedean tessellations for tissue regeneration. Despite similar porosity, tiles display vastly different tensile responses (1–100 MPa) and deformation modes. In vitro experiments with hMSCs show geometry‐dependent growth and activity. Over 55 000 tile combinations
Maria Kalogeropoulou, Kenny A. van Kampen, Pierpaolo Fucile, Carlos Mota, Lorenzo Moroni   +4 more
wiley   +1 more source

Th17 Cytokines Disrupt the Airway Mucosal Barrier in Chronic Rhinosinusitis

Mediators of Inflammation, 2016
Cytokine mediated changes in paracellular permeability contribute to a multitude of pathological conditions including chronic rhinosinusitis (CRS). The purpose of this study was to investigate the effect of interferons and of Th1, Th2, and Th17 cytokines
Mahnaz Ramezanpour, Sophia Moraitis, Jason L. P. Smith, P. J. Wormald, Sarah Vreugde   +4 more
doaj   +1 more source

Small Oligonucleotides Detection in Three-Dimensional Polymer Network of DNA-PEG Hydrogels

Gels, 2021
The control of the three-dimensional (3D) polymer network structure is important for permselective materials when specific biomolecule detection is needed.
Alessia Mazzarotta, Tania Mariastella Caputo, Luca Raiola, Edmondo Battista, Paolo Antonio Netti, Filippo Causa   +5 more
doaj   +1 more source

Characterizing anomalous diffusion in crowded polymer solutions and gels over five decades in time with variable-lengthscale fluorescence correlation spectroscopy [PDF]

, 2016
The diffusion of macromolecules in cells and in complex fluids is often found to deviate from simple Fickian diffusion. One explanation offered for this behavior is that molecular crowding renders diffusion anomalous, where the mean-squared displacement ...
Banks, Daniel S., Fradin, Cécile, Höfling, Felix, Peters, Robert D., Tressler, Charmaine   +4 more
core   +2 more sources

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Methodological aspects of determining molecular mass distribution of dextrans by size-exclusion chromatography for various groups of medicines

Регуляторные исследования и экспертиза лекарственных средств, 2018
The article analyses the results of quality evaluation of dextran substances and medicines produced thereof which was carried out by the Institution as part of pre-authorisation testing and involved the analysis of the «molecular mass distribution ...
R. S. Smirnov, E. V. Ivanainen, A. I. Lutseva, O. A. Vaganova, D. A. Orlov   +4 more
doaj  

Chromatographic Separation of Isomaltooligosaccharides on Ion-Exchange Resins: Effect of the Cationic Form

Adsorption Science & Technology, 2012
Prebiotic isomaltooligosaccharides (IMOs) are composed of α-d-glucose units linked by glucosidic α (1Ø6) bonds and they remain intact until reaching the large bowels, where they are metabolized by bifidobacteria and lactobacillus.
M.C. Rabelo, C.S.M. Pereira, S. Rodrigues, A.E. Rodrigues, D.C.S. Azevedo   +4 more
doaj   +1 more source