Results 11 to 20 of about 46,464 (291)

DHEA in Elderly Women and DHEA or Testosterone in Elderly Men [PDF]

Obstetrical & Gynecological Survey, 2006
Dehydroepiandrosterone (DHEA) and testosterone are widely promoted as antiaging supplements, but the long-term benefits, as compared with potential harm, are unknown.We performed a 2-year, placebo-controlled, randomized, double-blind study involving 87 elderly men with low levels of the sulfated form of DHEA and bioavailable testosterone and 57 elderly
NAIR KS, RIZZA RA, O'BRIEN P, DHATARIYA K, SHORT KR, NEHRA A, VITTONE JL, KLEE GG, BASU A, BASU R, COBELLI, CLAUDIO, TOFFOLO, GIANNA MARIA, DALLA MAN, CHIARA, TINDALL DJ, MELTON L, SMITH GE, KHOSLA S, JENSEN MD   +17 more
semanticscholar   +6 more sources

DHEA Attenuates Microglial Activation via Induction of JMJD3 in Experimental Subarachnoid Haemorrhage

Journal of Neuroinflammation, 2019
Background Microglia are resident immune cells in the central nervous system and central to the innate immune system. Excessive activation of microglia after subarachnoid haemorrhage (SAH) contributes greatly to early brain injury, which is responsible ...
Tao Tao, Guang-Jie Liu, Xuan Shi, Yan Zhou, Yue Lu, Yong-Yue Gao, Xiang-Sheng Zhang, Han Wang, Ling-Yun Wu, Chun-Lei Chen, Zong Zhuang, Wei Li, Chun-Hua Hang   +12 more
doaj   +2 more sources

In vivo activation of the constitutive androstane receptor β (CARβ) by treatment with dehydroepiandrosterone (DHEA) or DHEA sulfate (DHEA‐S) [PDF]

FEBS Letters, 2002
We investigated whether dehydroepiandrosterone (DHEA) or DHEA‐sulfate (S) affected the activities of nuclear receptors, with special reference to constitutive androstane receptor β (CARβ). Administration of DHEA or DHEA‐S enhanced the DNA binding of hepatic nuclear extracts to responsive elements for the retinoic acid receptor, the retinoic acid ...
Fujita, Atsushi, Furutama, Daisuke, Tanaka, Toshifumi, Sakai, Reiko, Koyama, Akio, Hanafusa, Toshiaki, Mitsuhashi, Tomoaki, Ohsawa, Nakaaki   +7 more
openaire   +3 more sources

Human DHEA sulfation requires direct interaction between PAPS synthase 2 and DHEA sulfotransferase SULT2A1 [PDF]

Journal of Biological Chemistry, 2018
The high-energy sulfate donor 3′-phosphoadenosine-5′-phosphosulfate (PAPS), generated by human PAPS synthase isoforms PAPSS1 and PAPSS2, is required for all human sulfation pathways.
Jonathan Wolf Mueller, Jan Idkowiak, T. F. Gesteira, Cecilia Vallet, Rebecca E. Hardman, J. van den Boom, V. Dhir, S. Knauer, E. Rosta, W. Arlt   +9 more
semanticscholar   +2 more sources

Testosterone, DHEA and DHEA-S in patients with schizophrenia: A systematic review and meta-analysis.

Psychoneuroendocrinology, 2018
Neuroactive steroids, including testosterone, dehydroepiandrosterone (DHEA) and its sulfate (DHEA-S) might play an important role in the pathophysiology of schizophrenia.
B. Misiak, D. Frydecka, Olga Loska, A. Moustafa, J. Samochowiec, J. Kasznia, B. Stańczykiewicz   +6 more
semanticscholar   +2 more sources

Lower DHEA and DHEA-S response during acute psychosocial stress is related to higher perceived stress at work

European Journal of Psychotraumatology, 2012
Background : Dehydroepiandrosterone (DHEA) and Dehydroepiandrosterone Sulfate (DHEA-S) increase during acute psychosocial stress is suggested to have a protective role against the negative consequences of cortisol.
Anna-Karin Lennartsson, Ingibjörg H. Jonsdottir   +1 more
doaj   +2 more sources

DHEA as a Biomarker of Stress: A Systematic Review and Meta-Analysis

Frontiers in Psychiatry, 2021
Background: Psychosocial stress is a significant public health problem inducing consequences for quality of life. Results about the use of dehydroepiandrosterone (DHEA) as a biomarker of acute stress are conflicting.
F. Dutheil, Sarah de Saint Vincent, B. Pereira, Jeannot Schmidt, F. Moustafa, M. Charkhabi, Jean-Baptiste Bouillon-Minois, Maëlys Clinchamps   +7 more
semanticscholar   +1 more source

Cortisol and DHEA as markers of placentitis in pregnant mares: a preliminary study [PDF]

, 2023
peer reviewedPlacentitis in mares is a subclinical cause of abortion, high- lighting the importance of early detection for successful treatment. Sexual steroids could serve as biomarkers, but cross-reactivity and a limited detection range of immunoassays
Caroline Le Goff, Etienne Cavalier, Peeters, Stéphanie, Le Goff, Caroline, Deleuze, Stefan, Joy Ledeck, Stefan Deleuze, Ledeck, Joy, Stéphanie Peeters, Cavalier, Etienne, Ponthier, Jérôme, Jérôme Ponthier   +11 more
core   +1 more source

Beyond Glucocorticoids: Integrating Dehydroepiandrosterone (DHEA) into Animal Welfare Research

Animals, 2020
Simple Summary It is considered best practice in the field of animal welfare to utilize multiple indicators of welfare when assessing an individual’s current state.
Jessica C Whitham, J. Bryant, L. Miller
semanticscholar   +1 more source

Cortisol and DHEA-S levels in pregnant women with severe anxiety

BMC Psychiatry, 2020
Background A complex interaction between cortisol and dehydroepiandrosterone-sulphate (DHEA-S) is crucial in the stress system balance; several studies have reported increased cortisol levels during chronic stress and a weak counter-regulation by DHEA-S.
Philippe Leff-Gelman, M. Flores-Ramos, A. Carrasco, Margarita López Martínez, M. Takashima, F. M. C. Coronel, Blanca Farfán Labonne, José Antonio Zorrilla Dosal, P. Chávez-Peón, S. G. Morales, I. Camacho-Arroyo   +10 more
semanticscholar   +1 more source