Results 31 to 40 of about 17,560 (201)

Dehydroepiandrosterone (DHEA) Feeding Protects Liver Steatosis in Obese Breast Cancer Rat Model

Scientia Pharmaceutica, 2017
Obesity is a major health problem in the US and globally. Obesity is associated with the risk of cardiovascular disease, type 2 diabetes, cancers, hyperlipidemia, and liver steatosis development. Dehydroepiandrosterone (DHEA) is a dietary supplement used
Reza Hakkak, Andrea Bell, Soheila Korourian   +2 more
doaj   +1 more source

Dehydroepiandrosterone exacerbates nigericin-induced abnormal autophagy and pyroptosis via GPER activation in LPS-primed macrophages

Cell Death and Disease, 2022
As a widely acknowledged FDA-approved dietary supplement or over-the-counter medicines, dehydroepiandrosterone (DHEA) exerts anti-inflammatory and immunomodulatory function. Pyroptosis is an important form of programmed cell death (PCD), and which acts a
Ji Cao, Longlong Li, Yao Yao, Yuxiao Xing, Haitian Ma   +4 more
doaj   +1 more source

The Immunoregulatory Actions of DHEA in Tuberculosis, A Tool for Therapeutic Intervention?

Frontiers in Endocrinology, 2022
Dehydroepiandrosterone (DHEA) is an androgen synthesized by the adrenal cortex, which is an intermediary in the biosynthesis of sex hormones, such as testosterone and estradiol. DHEA mostly circulates as a conjugated ester, in the form of sulfate (DHEA-S)
Bettina Bongiovanni, Bettina Bongiovanni, Bettina Bongiovanni, Ariana Díaz, Ariana Díaz, Natalia Santucci, Natalia Santucci, Luciano David D’Attilio, Luciano David D’Attilio, Oscar Bottasso, Oscar Bottasso, Rogelio Hernández Pando, María Luisa Bay, María Luisa Bay   +13 more
doaj   +1 more source

Transcriptomic Profiling of SLC and ABC Transporters in the Human Term Placenta

Clinical Pharmacology &Therapeutics, EarlyView.
Solute carriers (SLC) and ATP‐binding cassette (ABC) transporters are essential for placental solute exchange and fetal protection, yet their transcriptomic profiles in the human placenta remain poorly characterized. Although fetal sex influences placental development and function, its impact on transporter expression is unclear.
Elijah Marsh Jung, Nicholas Ieronimakis, Bothaina Mousa, Emily D. Sheikh, Sarah E. Ligon, Joshua W. Monson, Jennifer R. Damicis, Hillary J. Kinsman, Lydia E. Bettridge, Samuel L.M. Arnold, Edward J. Kelly, Jashvant D. Unadkat, Joanne Wang   +12 more
wiley   +1 more source

Liver cirrhosis is associated with altered glucocorticoid metabolism related to disease severity. [PDF]

J Intern Med
Abstract Background Liver cirrhosis (LC) is frequently complicated by adrenal dysfunction; however, whether cirrhosis drives the coordinated, pathway‐specific reprogramming of cortisol metabolism remains unclear. Objectives We aimed to characterize axis‐specific alterations in cortisol metabolism in patients with LC, those with adrenal insufficiency ...
Park S, Park MJ, Yang HW, Park J, Yu SJ, Park SS, Choi MH, Cho EJ, Kim JH.   +8 more
europepmc   +2 more sources

Supercritical Fluid Chromatography for Expedited Sample Clean‐Up in Isotope Ratio Mass Spectrometry Including Cholesterol as New Endogenous Reference Compound

Drug Testing and Analysis, EarlyView.
Supercritical fluid chromatography was employed in the sample preparation for IRMS determinations in sports drug testing for the first time and the developed method was successfully validated. Cholesterol (CHOL) was introduced as a novel endogenous reference compound and population‐based Δ‐values were established as shown here.
Thomas Piper, Jana Drewes, Mario Thevis
wiley   +1 more source

DHEA-Bodipy—A functional fluorescent DHEA analog for live cell imaging [PDF]

Molecular and Cellular Endocrinology, 2010
The androgen dehydroepiandrosterone (DHEA) has been reported to protect neuronal cells against dysfunction and apoptosis. Several signaling pathways involved in these effects have been described but little is known about the intracellular trafficking of DHEA.
Lemcke, Susanne, Hönnscheidt, Christoph, Waschatko, Gustav, Bopp, Anita, Lütjohann, Dieter, Bertram, Norbert, Gehrig-Burger, Katja   +6 more
openaire   +2 more sources

Potential Contamination Cases in Anti‐Doping: Experiences and Practices of 33 Anti‐Doping Organisations

Drug Testing and Analysis, EarlyView.
Across 33 Anti‐Doping Organisations (ADOs), 85% reported experiencing at least one contamination‐claim case in 2024–2025, but only 36% operate a standardised process for handling such claims. Dietary supplements were the leading alleged contamination source (76% of ADOs), followed by food (42%) and pharmaceutical products, intimate contact, and other ...
Kristian Slíž, Liene Kozlovska, Fredrik Lauritzen   +2 more
wiley   +1 more source

Exploring the connection between several neurosteroid hormones and first-episode psychosis and schizophrenia: A literature review

Annales Academiae Medicae Silesiensis
First-episode psychosis (FEP) and first-episode schizophrenia (FES) are serious psychiatric conditions. Neurosteroids, known to modulate central nervous system function, may play a role in the pathophysiology of these disorders.
Alicja Gładysz, Alicja Dydyna, Martyna Mościcka, Marta Gierlik   +3 more
doaj   +1 more source

Central intracrine DHEA synthesis in ageing-related neuroinflammation and neurodegeneration: therapeutic potential?

Journal of Neuroinflammation, 2018
It is a well-known fact that DHEA declines on ageing and that it is linked to ageing-related neurodegeneration, which is characterised by gradual cognitive decline.
Y S L Powrie, C Smith
doaj   +1 more source