Results 51 to 60 of about 46,464 (291)

The Utilization of Dehydroepiandrosterone as a Sexual Hormone Precursor in Premenopausal and Postmenopausal Women: An Overview

Pharmaceuticals, 2021
Dehydroepiandrosterone (DHEA), and its metabolite, dehydroepiandrosterone sulfate ester (DHEAS), are the most abundant circulating steroid hormones, and are synthesized in the zona reticularis of the adrenal cortex, in the gonads, and in the brain.
Justine Tang, Li-Ru Chen, Kuo-Hu Chen
doaj   +1 more source

Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) protect hippocampal neurons against excitatory amino acid-induced neurotoxicity [PDF]

Proceedings of the National Academy of Sciences, 1998
DHEA, together with DHEAS, is the most abundant steroid in the blood of young adult humans. Levels in humans decline with age and during certain types of illness or stress. We have found that DHEA(S) can prevent or reduce the neurotoxic actions in the hippocampus of the glutamate agonists N -methyl- d
V G, Kimonides, N H, Khatibi, C N, Svendsen, M V, Sofroniew, J, Herbert   +4 more
openaire   +2 more sources

The diurnal patterns of the adrenal steroids cortisol and dehydroepiandrosterone (DHEA) in relation to awakening

, 2005
The steroid hormones, cortisol and dehydroepiandrosterone (DHEA) are the two main peripheral secretory products of the hypothalamic-pituitary-adrenal stress-neuroendocrine axis.
Evans, P., Ussher, M., McEwen, A., Hussain, T., Hucklebridge, F., Clow, A., Steptoe, A., West, R.   +7 more
core   +1 more source

Exploring the connection between several neurosteroid hormones and first-episode psychosis and schizophrenia: A literature review

Annales Academiae Medicae Silesiensis
First-episode psychosis (FEP) and first-episode schizophrenia (FES) are serious psychiatric conditions. Neurosteroids, known to modulate central nervous system function, may play a role in the pathophysiology of these disorders.
Alicja Gładysz, Alicja Dydyna, Martyna Mościcka, Marta Gierlik   +3 more
doaj   +1 more source

Central intracrine DHEA synthesis in ageing-related neuroinflammation and neurodegeneration: therapeutic potential?

Journal of Neuroinflammation, 2018
It is a well-known fact that DHEA declines on ageing and that it is linked to ageing-related neurodegeneration, which is characterised by gradual cognitive decline.
Y S L Powrie, C Smith
doaj   +1 more source

Dehydroepiandrosterone alleviates oleic acid-induced lipid metabolism disorders through activation of AMPK-mTOR signal pathway in primary chicken hepatocytes

Poultry Science, 2023
: The incident of lipid metabolism disorders has obviously increased under the undue pursuit of efficiency, which had seriously threatened to the health development of poultry industry.
Yao Yao, Ying Yang, Huihui Wang, Zhihao Jiang, Haitian Ma   +4 more
doaj   +1 more source

Analytical and Workflow Performance of a High‐Throughput Chemiluminescent Immunoassay System in a Clinical Laboratory

Journal of Clinical Laboratory Analysis, EarlyView.
Analytical and operational performance evaluation of the DxI 9000 Access Immunoassay Analyzer in a clinical laboratory in Taiwan. ABSTRACT Background Increasing test volumes and shorter turnaround time (TAT) requirements, particularly in acute‐care settings, challenge clinical laboratories to maintain accurate immunoassay testing.
Chiung‐Tzu Hsiao, Chao‐Ching Liao, Yu‐Chang Chang, Hui‐Ju Chang, Tz‐Ya Huang, Jen‐Shiou Lin, Po‐Ren Hsueh   +6 more
wiley   +1 more source

In rats, oral oleoyl-DHEA is rapidly hydrolysed and converted to DHEA-sulphate [PDF]

, 2007
Background: Dehydroepiandrosterone (DHEA) released by adrenal glands may be converted to androgens and estrogens mainly in the gonadal, adipose, mammary, hepatic and nervous tissue.
Fernández López, José Antonio, Serrano Muñoz, Marta, Maria del Mar Grasa, Marià Alemany, Alemany, Marià, 1946-, José Antonio Fernández-López, Grasa Martínez, Maria del Mar, Marta Serrano   +7 more
core   +1 more source

The Immunoregulatory Actions of DHEA in Tuberculosis, A Tool for Therapeutic Intervention?

Frontiers in Endocrinology, 2022
Dehydroepiandrosterone (DHEA) is an androgen synthesized by the adrenal cortex, which is an intermediary in the biosynthesis of sex hormones, such as testosterone and estradiol. DHEA mostly circulates as a conjugated ester, in the form of sulfate (DHEA-S)
Bettina Bongiovanni, Bettina Bongiovanni, Bettina Bongiovanni, Ariana Díaz, Ariana Díaz, Natalia Santucci, Natalia Santucci, Luciano David D’Attilio, Luciano David D’Attilio, Oscar Bottasso, Oscar Bottasso, Rogelio Hernández Pando, María Luisa Bay, María Luisa Bay   +13 more
doaj   +1 more source

Steroidopathies and hormonal imbalance in children and adolescents with autism spectrum disorder

JCPP Advances, EarlyView.
Abstract Background Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition with a multifactorial etiology, many aspects of which remain unclear. Emerging evidence suggests a potential association between ASD and clinical manifestations resulting from hormonal imbalances, henceforth named “steroidopathies.” The present study aims to ...
Concetta de Giambattista, Patrizia Ventura, Samuele Cortese, Paolo Trerotoli, Alessandra Di Gioia, Lucia Margari   +5 more
wiley   +1 more source