Results 21 to 30 of about 17,560 (201)

Impacts of adrenarcheal DHEA levels on spontaneous cortical activity during development

Developmental Cognitive Neuroscience, 2022
Dehydroepiandrosterone (DHEA) production is closely associated with the first pubertal hormonal event, adrenarche. Few studies have documented the relationships between DHEA and functional brain development, with even fewer examining the associations ...
Samantha H. Penhale, Giorgia Picci, Lauren R. Ott, Brittany K. Taylor, Michaela R. Frenzel, Jacob A. Eastman, Yu-Ping Wang, Vince D. Calhoun, Julia M. Stephen, Tony W. Wilson   +9 more
doaj   +1 more source

Short‐term rapamycin administration elevated testosterone levels and exacerbated reproductive disorder in dehydroepiandrosterone‐induced polycystic ovary syndrome mice

Journal of Ovarian Research, 2021
Background Polycystic ovary syndrome (PCOS) is a multifactorial endocrinopathy that affects reproduction and metabolism. Mammalian target of rapamycin (mTOR) has been shown to participate in female reproduction under physiological and pathological ...
Zaixin Guo, Xiaohan Chen, Penghui Feng, Qi Yu   +3 more
doaj   +1 more source

Vasodilator effects of dehydroepiandrosterone (DHEA) on fetal pulmonary circulation: An experimental study in pregnant sheep. [PDF]

PLoS ONE, 2018
Persistent pulmonary hypertension (PPHN) remains a severe complication of the transition to extra-uterine life with significant morbidity and mortality in the newborns.
Dyuti Sharma, Hélène Coridon, Estelle Aubry, Ali Houeijeh, Véronique Houfflin-Debarge, Rémi Besson, Philippe Deruelle, Laurent Storme   +7 more
doaj   +1 more source

Low Levels of Dehydroepiandrosterone Sulfate in Younger Burnout Patients. [PDF]

PLoS ONE, 2015
Dehydroepiandrosterone sulphate (DHEA-s) is an anabolic protective hormone of importance for maintenance of health. DHEA-s levels peak in young adults and decline thereafter with age.
Anna-Karin Lennartsson, Töres Theorell, Mark M Kushnir, Ingibjörg H Jonsdottir   +3 more
doaj   +1 more source

Sex-specific effects of serum sulfate level and SLC13A1 nonsense variants on DHEA homeostasis

Molecular Genetics and Metabolism Reports, 2017
Context: Sulfate is critical in the biotransformation of multiple compounds via sulfation. These compounds include neurotransmitters, proteoglycans, xenobiotics, and hormones such as dehydroepiandrosterone (DHEA).
Christina G. Tise, Leslie E. Anforth, Albert E. Zhou, James A. Perry, Patrick F. McArdle, Elizabeth A. Streeten, Alan R. Shuldiner, Laura M. Yerges-Armstrong   +7 more
doaj   +1 more source

The relationship between dehydroepiandrosterone (DHEA), working memory and distraction--a behavioral and electrophysiological approach. [PDF]

PLoS ONE, 2014
Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulphate (DHEAS) have been reported to have memory enhancement effects in humans. A neuro-stimulatory action and an anti-cortisol mechanism of action may contribute to that relation.
Sónia do Vale, Lenka Selinger, João Martin Martins, Ana Coelho Gomes, Manuel Bicho, Isabel do Carmo, Carles Escera   +6 more
doaj   +1 more source

DHEA administration and exercise training improves insulin resistance in obese rats

Nutrition & Metabolism, 2012
Background Dehydroepiandrosterone (DHEA) is precursor of sex steroid hormone. We demonstrated that acute DHEA injection to type 1 diabetes model rats induced improvement of hyperglycemia.
Sato Koji, Iemitsu Motoyuki, Aizawa Katsuji, Mesaki Noboru, Ajisaka Ryuichi, Fujita Satoshi   +5 more
doaj   +1 more source

Serum Dehydroepiandrosterone (DHEA) and DHEA-Sulfate (DHEA-S) in Alzheimer's Disease and in Cerebrovascular Dementia.

Endocrine Journal, 1996
A decreased concentration of dehydroepiandrosterone sulfate (DHEA-S) in patients with Alzheimer's disease (AD) has been reported but is still controversial. In the present study, serum concentrations of DHEA and DHEA-S were determined in 19 patients with AD, 21 patients with cerebrovascular dementia (CVD) and 45 age- and gender matched elderly control ...
YANASE, TOSHIHIKO, FUKAHORI, MOTOFUMI, TANIGUCHI, SUSUMU, NISHI, YOSHIHIRO, SAKAI, YOSHIYUKI, TAKAYANAGI, RYOICHI, HAJI, MASAFUMI, NAWATA, HAJIME   +7 more
openaire   +3 more sources

Cellular and molecular mechanisms of action of neurosteroids in various parts of the central nervous system (Part 2)

Якутский медицинский журнал
Neurosteroids (or neuroactive steroids) are a class of endogenous compounds which are synthesized in nervous tissue or\and able to modulate the brain functional activity, the class also includes steroids from gonads or adrenals, which are capable of ...
D. V. Dmitrenko, S. N. Zobova, T. G. Ruksha, T. I. Prusova, A. A. Usoltseva   +4 more
doaj   +1 more source

A Novel NR3C1 Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural Modeling

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Glucocorticoid resistance syndrome (GRS) is a rare hereditary disorder caused by pathogenic variants in NR3C1, characterized by marked phenotypic heterogeneity and frequent misdiagnosis as primary aldosteronism or subclinical Cushing's syndrome.
Sufang Yun, Zhifeng Zhu, Fengye Zhou, Ying Liu, Chunfang Liang, Haitao Ju, Lin Lu, Zhaoli Yan   +7 more
wiley   +1 more source