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Dietary CoQ10 Ameliorates Age‐Related Megakaryocyte Dysfunction via COPS3‐Mediated Activation of Autophagy [PDF]
Aging Cell, Volume 25, Issue 10, October 2026.Dietary CoQ10 improves megakaryocyte maturation and polyploidization and reduces platelet hyperreactivity in naturally aged mice, while experiments in senescent Meg‐01 cells demonstrate enhanced autophagic flux and identify COPS3 as a contributing, but not, mediator.
Yixuan Xu +9 more
wiley +2 more sources
CoQ10'nin solunum zincirindeki etkisi
Sakarya Tıp Dergisi, 2013 CoQ10 seviyesinin yaşlanmayla birlikte azaldığı bilinmektedir. Kalp sağlığı için CoQ10'nin seviyesi önemlidir. CoQ10 mitokondrial solunum zincirinde bir elektron taşıyıcısı olarak, bunu yanı sıra önemli bir hücre içi antioksidan olarak görev yapar. CoQ10
Başar Altınterim
doaj +3 more sources
Water-soluble coenzyme Q10 provides better protection than lipid-soluble coenzyme Q10 in a rat model of chronic tacrolimus nephropathy [PDF]
The Korean Journal of Internal Medicine, 2021 Background/Aims Coenzyme Q10 (CoQ10), is a promising antioxidant; however, low bioavailability owing to lipid-solubility is a limiting factor. We developed water-soluble CoQ10 (CoQ10-W) and compared its effects with conventional lipid-soluble CoQ10 ...
Sheng Cui +12 more
doaj +1 more source
Hepatoprotective Effect of Coenzyme Q10 in Rats with Diclofenac Toxicity [PDF]
Archives of Razi Institute, 2022 The liver and kidney are the most important organs in the body, and they both act as target structures for drug-induced injury as a consequence of their functions in metabolisms, detoxifications, storage, elimination of medications, and their metabolites.
Z Abed Al-Kareem +2 more
doaj +1 more source
The therapeutic efficacy of water-soluble coenzyme Q10 in an experimental model of tacrolimus-induced diabetes mellitus [PDF]
The Korean Journal of Internal Medicine, 2020 Background/Aims Coenzyme Q10 (CoQ10) has antioxidant effects and is commercially available and marketed extensively. However, due to its low bioavailability, its effects are still controversial.
Yi Quan +10 more
doaj +1 more source
Molecular Genetics and Metabolism Reports, 2023 Coenzyme Q10 (CoQ10) is involved in ATP production through electron transfer in the mitochondrial respiratory chain complex. CoQ10 receives electrons from respiratory chain complex I and II to become the reduced form, and then transfers electrons at ...
Chika Watanabe +14 more
doaj +1 more source
Antioxidants, 2022 Myalgia and new-onset of type 2 diabetes have been associated with statin treatment, which both could be linked to reduced coenzyme Q10 (CoQ10) in skeletal muscle and impaired mitochondrial function. Supplementation with CoQ10 focusing on levels of CoQ10
Tine L. Dohlmann +10 more
doaj +1 more source
Histopathological and Biomechanical Survey on Effect of CoQ10 in Combination with Chitosan Conduit on Deep Digital Flexor Tendon Healing in Rabbits [PDF]
Iranian Journal of Veterinary Surgery, 2020 Objective- Chitosan is of great interest in regenerative medicine because of its plentiful properties, like biocompatibility, biodegradability and non-toxicity.
Saba Moghadam, Amir Amniattalab
doaj +1 more source
Coenzyme Q10 coadministration with diclofenac augmented impaired renal function in broiler chickens (Gallus gallus domesticus) [PDF]
Veterinary World, 2020 Aim: This study aimed to investigate the effects of coenzyme Q10 (COQ10) and diclofenac coadministration on the hepatorenal function in broiler chickens (Gallus gallus domesticus).
Yasser Albadrany, Ahmed Naser
doaj +1 more source
Biology, 2019 The aging process includes impairment in mitochondrial function, a reduction in anti-oxidant activity, and an increase in oxidative stress, marked by an increase in reactive oxygen species (ROS) production. Oxidative damage to macromolecules including DNA and electron transport proteins likely increases ROS production resulting in further damage.
Isabella Peixoto de Barcelos +1 more
openaire +5 more sources