Spatial mapping of CoQ10 repletion by BPM31510 in a genetic mouse model (Coq4F147C) of coenzyme Q deficiency [PDF]
Journal of Lipid ResearchPrimary coenzyme Q10 (CoQ10) deficiency is a rare mitochondrial disorder caused by mutations in genes involved in CoQ biosynthesis (e.g., COQ4) that result in impaired mitochondrial respiration, oxidative stress, and dysfunction across multiple organ ...
Eliana Barriocanal-Casado +15 more
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Higher Redox State of Coenzyme Q10 Is Associated with Higher Risk of All-Cause Mortality in a Sample from the Northern German General Population [PDF]
AntioxidantsCoenzyme Q10 (CoQ10) plays an important role in human health; for example, through the antioxidant function of its reduced form (ubiquinol). As the long-term health effects of circulating CoQ10 remain largely unknown, we examined the association of total
Paula Stürmer +7 more
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Blood–Brain Barrier and Neuronal Model Systems for Studying CoQ10 Metabolism [PDF]
AntioxidantsThe disparity in outcomes between preclinical and clinical studies supplementing coenzyme Q10 (CoQ10) in neurological disorders may be a reflection of the differences in the ability of supplemental CoQ10 to access the blood–brain barrier (BBB) in rodents
David Mantle +3 more
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Water-soluble coenzyme Q10 provides better protection than lipid-soluble coenzyme Q10 in a rat model of chronic tacrolimus nephropathy [PDF]
The Korean Journal of Internal Medicine, 2021 Background/Aims Coenzyme Q10 (CoQ10), is a promising antioxidant; however, low bioavailability owing to lipid-solubility is a limiting factor. We developed water-soluble CoQ10 (CoQ10-W) and compared its effects with conventional lipid-soluble CoQ10 ...
Sheng Cui +12 more
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The therapeutic efficacy of water-soluble coenzyme Q10 in an experimental model of tacrolimus-induced diabetes mellitus [PDF]
The Korean Journal of Internal Medicine, 2020 Background/Aims Coenzyme Q10 (CoQ10) has antioxidant effects and is commercially available and marketed extensively. However, due to its low bioavailability, its effects are still controversial.
Yi Quan +10 more
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Hepatoprotective Effect of Coenzyme Q10 in Rats with Diclofenac Toxicity [PDF]
Archives of Razi Institute, 2022 The liver and kidney are the most important organs in the body, and they both act as target structures for drug-induced injury as a consequence of their functions in metabolisms, detoxifications, storage, elimination of medications, and their metabolites.
Z Abed Al-Kareem +2 more
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Molecular Genetics and Metabolism Reports, 2023 Coenzyme Q10 (CoQ10) is involved in ATP production through electron transfer in the mitochondrial respiratory chain complex. CoQ10 receives electrons from respiratory chain complex I and II to become the reduced form, and then transfers electrons at ...
Chika Watanabe +14 more
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Histopathological and Biomechanical Survey on Effect of CoQ10 in Combination with Chitosan Conduit on Deep Digital Flexor Tendon Healing in Rabbits [PDF]
Iranian Journal of Veterinary Surgery, 2020 Objective- Chitosan is of great interest in regenerative medicine because of its plentiful properties, like biocompatibility, biodegradability and non-toxicity.
Saba Moghadam, Amir Amniattalab
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Antioxidants, 2022 Myalgia and new-onset of type 2 diabetes have been associated with statin treatment, which both could be linked to reduced coenzyme Q10 (CoQ10) in skeletal muscle and impaired mitochondrial function. Supplementation with CoQ10 focusing on levels of CoQ10
Tine L. Dohlmann +10 more
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Coenzyme Q10 coadministration with diclofenac augmented impaired renal function in broiler chickens (Gallus gallus domesticus) [PDF]
Veterinary World, 2020 Aim: This study aimed to investigate the effects of coenzyme Q10 (COQ10) and diclofenac coadministration on the hepatorenal function in broiler chickens (Gallus gallus domesticus).
Yasser Albadrany, Ahmed Naser
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