Measurement of 11-Oxo-androgens, A Novel Biomarker, in Females with Clinical Signs of Premature Adrenarche [PDF]
JCRPEObjective: Endocrine findings in premature adrenarche have been characterized by elevated dehydroepiandrosterone (DHEA) DHEA-sulfate (DHEA-S) levels in the past. Methods: We reviewed female patients, aged 4 to 8 years, with premature adrenarche who were
Liana Gabriel +5 more
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Clinical Characteristics and Thyroid Findings in Children with Isolated Premature Adrenarche [PDF]
ChildrenObjectives: Premature adrenarche (PA) is associated with accelerated adrenal maturation, but data regarding thyroid characteristics in children with isolated PA are limited.
Sibel Aka +3 more
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Adrenarche, social cognition, and the development and evolution of autism spectrum traits [PDF]
Frontiers in PsychiatryAutism Spectrum Disorder (ASD) is a heterogeneous neurodevelopmental condition characterized by underdeveloped social cognition, along with restricted interests and repetitive behaviors.
Cory Szakal, Bernard Crespi
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Anti-aging effects of the adrenal androgens dehydroepiandrosterone and dehydroepiandrosterone sulfate: mechanisms of action and beneficial effects in older people [PDF]
Endocrine JournalWe review the recent remarkable progress of the molecular mechanisms of action of the adrenal androgens dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) regarding their beneficial effects on older people and adrenal regenerative ...
Hajime Nawata +4 more
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Psychiatric and psychosocial characteristics of children with premature adrenarche: a prospective study [PDF]
BMC PediatricsAim Although psychiatric disorders such as depression and anxiety have been reported to be more common in children with precocious puberty, the psychosocial characteristics of puberty variants remain unclear.
Gülçin Arslan +6 more
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Developmental Cognitive Neuroscience, 2017 Substantial hormonal and neurobiological changes occur during puberty, and are widely argued to render this period of life a sensitive period in terms of risk for mental health problems. However, there is a paucity of research focusing on adrenarche, the
Nicholas B. Allen +2 more
exaly +3 more sources
A rise in prepubertal DHEA in the spiny mouse reveals the effect of adrenarche on the reproductive axis [PDF]
BMC BiologyBackground Adrenarche, characterized by rising adrenal dehydroepiandrosterone (DHEA) levels, precedes puberty and has been implicated in reproductive maturation, and disorders like polycystic ovary syndrome (PCOS).
Maya Sudman +8 more
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The sex-specific role of adrenal androgens in youth psychopathology [PDF]
Translational PsychiatryAdolescence is a vulnerable period for the emergence of mental health problems. Adrenarche, an early stage of pubertal development marked by rising adrenal androgens, particularly dehydroepiandrosterone (DHEA), may influence emotional and behavioral ...
Franka Edith Weisner +7 more
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Differential methylation pattern in pubertal girls associated with biochemical premature adrenarche
Epigenetics, 2023 Biochemical premature adrenarche is defined by elevated serum DHEAS [≥40 μg/dL] before age 8 y in girls. This condition is receiving more attention due to its association with obesity, hyperinsulinemia, dyslipidemia, and polycystic ovary syndrome ...
Karin B. Michels +2 more
exaly +2 more sources
Association of obesity and adrenal androgen levels with bone age progression in boys with premature adrenarche [PDF]
Annals of Pediatric Endocrinology & MetabolismPurpose Both premature adrenarche (PA) and obesity are closely linked to increases in bone age (BA). However, the mechanisms underlying these associations are unclear as research data, particularly in boys, are lacking.
Kyeongmi Lee +3 more
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