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Normal pubertal development in humans involves two distinct processes: maturation of adrenal androgen secretion (adrenarche) and activation of the hypothalamic–pituitary–gonadal axis (gonadarche). One factor thought to contribute to the adrenarche in man is increased adrenal 17-hydroxylase (CYP17) activity.
Duarte, Pignatelli +4 more
openaire +2 more sources
Puberty in children with Prader-Willi syndrome (PWS) is usually delayed and/or incomplete but in some patients premature/early adrenarche is observed. We assessed the premature adrenarche (PA) in PWS patients during the recombinant human growth hormone ...
Agnieszka Lecka-Ambroziak +4 more
doaj +1 more source
Purpose of review Adrenarche is the pubertal maturation of the innermost zone of the adrenal cortex, the zona reticularis. The onset of adrenarche occurs between 6 and 8 years of age when dehydroepiandrosterone sulfate (DHEAS) concentrations increase.
Selma Feldman, Witchel +3 more
openaire +3 more sources
Etiology and clinical features of precocious puberty in children referred to the endocrinology clinic of Kashan University of Medical Sciences, Iran [PDF]
Background and Aim: Precocious puberty presents a variety of causes and clinical features, with its prevalence on the rise. This study aimed at investigating the etiology and clinical characteristics of precocious puberty in children referred to the ...
kobra shiasi arani +2 more
doaj
From adrenarche to aging of adrenal zona reticularis: precocious female adrenopause onset
Objective: Adaptive changes in DHEA and sulfated-DHEA (DHEAS) production from adrenal zona reticularis (ZR) have been observed in normal and pathological conditions.
Emanuelle Nunes-Souza +16 more
doaj +1 more source
Associations between multi-method latent factors of puberty and brain structure in adolescent girls
Pubertal processes are associated with structural brain development, but studies have produced inconsistent findings that may relate to different measurements of puberty.
Michelle L. Byrne +13 more
doaj +1 more source
Premature pubarche as a first presentation of pituitary macroprolactinoma
Prolactinoma is a rare tumor of childhood. Clinical presentations of prolactinoma include amenorrhea, delayed puberty, and galactorrhea. For the first time, in this case, elevated prolactin levels were associated with unexpected premature pubarche.
Fatemeh Tabatabaei +5 more
doaj +1 more source
The Relationship Between Premature Adrenarche and Platelet Aggregation
INTRODUCTION: Premature adrenarche (PA) has been associated with an increase in adrenal androgens, and the hyperandrogenic hormonal environment is known to lead to increased platelet (PLT) aggregation.
Ahmet Bolat +4 more
doaj +1 more source
BackgroundAdrenarche is a key early life event that marks middle childhood at approximately 7 years of age. Earlier work with British-Bangladeshi migrant women suggested that environmental conditions experienced before adrenarche influence adult ...
Lauren C Houghton +8 more
doaj +1 more source
Most children with non-classic congenital adrenal hyperplasia (NC-CAH) due to 21-hydroxylase deficiency are asymptomatic and do not require cortisol replacement therapy unless they develop symptoms of hyperandrogenemia.
Sandy C. Liu +5 more
doaj +1 more source

