Results 51 to 60 of about 5,587,889 (314)

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

open access: yesFEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez   +3 more
wiley   +1 more source

Care, Education, protection – the Associação Protectora dos Diabéticis de Portugal goes from strength to strength [PDF]

open access: yes, 2012
The Portuguese Diabetes Association is the world’s oldest diabetes association and a senior Member Association of the International Diabetes Federation.
Valente Nabais, Joao
core  

The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus.

open access: yesNew England Journal of Medicine, 1993
BACKGROUND Long-term microvascular and neurologic complications cause major morbidity and mortality in patients with insulin-dependent diabetes mellitus (IDDM).
Diabetes Control   +8 more
semanticscholar   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

open access: yesFEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek   +15 more
wiley   +1 more source

Variable Weights Neural Network For Diabetes Classification [PDF]

open access: yesarXiv, 2021
As witnessed in the past year, where the world was brought to the ground by a pandemic, fighting Life-threatening diseases have found greater focus than ever. The first step in fighting a disease is to diagnose it at the right time. Diabetes has been affecting people for a long time and is growing among people faster than ever. The number of people who
arxiv  

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

open access: yesFEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Assessing the effectiveness of a clinic-based diabetes management program in a community setting [PDF]

open access: yes, 2013
Diabetes in the United States occurs in approximately 8% of adults.[i] Diabetes, if not treated, can lead to many health problems such as blindness or loss of physical functioning, sometimes leading to amputation. However, Type 2 diabetes can be cured
Lupone, Justin
core   +1 more source

Searching for "monogenic diabetes" in dogs using a candidate gene approach [PDF]

open access: yes, 2014
BACKGROUND: Canine diabetes is a common endocrine disorder with an estimated breed-related prevalence ranging from 0.005% to 1.5% in pet dogs. Increased prevalence in some breeds suggests that diabetes in dogs is influenced by genetic factors and ...
Catchpole, B   +7 more
core   +2 more sources

Autophagy in cancer and protein conformational disorders

open access: yesFEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

The Diabetic Buddy: A Diet Regulator andTracking System for Diabetics [PDF]

open access: yesarXiv, 2021
The prevalence of Diabetes mellitus (DM) in the Middle East is exceptionally high as compared to the rest of the world. In fact, the prevalence of diabetes in the Middle East is 17-20%, which is well above the global average of 8-9%. Research has shown that food intake has strong connections with the blood glucose levels of a patient.
arxiv  

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