Results 51 to 60 of about 1,112,461 (309)

Murine Nephrotoxic Nephritis as a Model of Chronic Kidney Disease

International Journal of Nephrology, 2018
Using the nonaccelerated murine nephrotoxic nephritis (NTN) as a model of chronic kidney disease (CKD) could provide an easily inducible model that enables a rapid test of treatments.
M. K. E. Ougaard, P. H. Kvist, H. E. Jensen, C. Hess, I. Rune, H. Søndergaard   +5 more
doaj   +1 more source

Sequence features of retrotransposons allow for epigenetic variability

eLife, 2021
Transposable elements (TEs) are mobile genetic elements that make up a large fraction of mammalian genomes. While select TEs have been co-opted in host genomes to have function, the majority of these elements are epigenetically silenced by DNA ...
Kevin R Costello, Amy Leung, Candi Trac, Michael Lee, Mudaser Basam, J Andrew Pospisilik, Dustin E Schones   +6 more
doaj   +1 more source

Diabetic Cardiovascular Disease Induced by Oxidative Stress. [PDF]

, 2015
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality among patients with diabetes mellitus (DM). DM can lead to multiple cardiovascular complications, including coronary artery disease (CAD), cardiac hypertrophy, and heart failure
Adam, Matti, Jagger, Ann, Kayama, Yosuke, Raaz, Uwe, Sakamoto, Masaya, Schellinger, Isabel N, Spin, Joshua M, Suzuki, Hirofumi, Toyama, Kensuke, Tsao, Philip S   +9 more
core   +2 more sources

Complications of Diabetes Therapy [PDF]

Endocrinology and Metabolism Clinics of North America, 2013
Current strategies for the treatment of type 2 diabetes mellitus promote individualized plans to achieve target glucose levels on a patient-by-patient basis while minimizing treatment related risks. Maintaining glycemic control over time is a significant challenge because of the progressive nature of diabetes as a result of declining β-cell function ...
Sarah D, Corathers, Shawn, Peavie, Marzieh, Salehi   +2 more
openaire   +2 more sources

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

Type 1 diabetes [PDF]

, 2018
Type 1 diabetes is a chronic autoimmune disease characterised by insulin deficiency and resultant hyperglycaemia. Knowledge of type 1 diabetes has rapidly increased over the past 25 years, resulting in a broad understanding about many aspects of the ...
DiMeglio, Linda A., Evans-Molina, Carmella, Oram, Richard A.   +2 more
core   +1 more source

A Bibliometric Analysis of Publications in Uremic Toxins From 1991 to 2024

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Uremic toxins are a growing area of research in nephrology, with significant implications in the progression and treatment of chronic kidney disease (CKD) and the management of end‐stage kidney disease (ESKD). This bibliometric analysis aims to evaluate the global research trends, key contributors, and the impact of publications in ...
Yuh‐Shan Ho, Karim M. Soliman, Wisit Cheungpasitporn, Wannasit Wathanavasin, Ahmed Daoud, Ahmed I. Kamal, Balázs Szamosfalvi, Tibor Fülöp   +7 more
wiley   +1 more source

Gaps in obesity education - thematic narrative analysis from healthcare graduates: findings from the Erasmus Mundus EMINENT project

BMC Medical Education
Background Obesity is a complex, chronic disease with significant global health implications, yet its management remains underrepresented in medical and allied health education.
Tak Ying Louise Ko, Francisca Contreras, Carel W. le Roux, Werd Al-Najim   +3 more
doaj   +1 more source

Targeted screening and identification of chlorhexidine as a pro-myogenic circadian clock activator

Stem Cell Research & Therapy, 2023
Background The circadian clock is an evolutionarily conserved mechanism that exerts pervasive temporal control in stem cell behavior. This time-keeping machinery is required for orchestrating myogenic progenitor properties in regenerative myogenesis that
Tali Kiperman, Weini Li, Xuekai Xiong, Hongzhi Li, David Horne, Ke Ma   +5 more
doaj   +1 more source

Vascular Regulation by Super Enhancer-Derived LINC00607

Frontiers in Cardiovascular Medicine, 2022
Vascular endothelial cells (ECs) play a pivotal role in whole body homeostasis. Recent advances have revealed enhancer-associated long non-coding RNAs (lncRNAs) as essential regulators in EC function.
Kiran Sriram, Kiran Sriram, Yingjun Luo, Dongqiang Yuan, Naseeb Kaur Malhi, Alonso Tapia, Alonso Tapia, Vishnu Amaram Samara, Vishnu Amaram Samara, Rama Natarajan, Rama Natarajan, Zhen Bouman Chen, Zhen Bouman Chen   +12 more
doaj   +1 more source