Results 51 to 60 of about 2,935,189 (309)

“We Cannot Talk as a Family”: Complexities of Survivorship Communication Among Hispanic/Latino Young Adult Survivors of Childhood Cancer, Parents, and Clinicians

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Young adult childhood cancer survivors (YA‐CCS) have an increased risk of treatment‐related health complications throughout their lives. Lifelong survivorship care is recommended, yet many YA‐CCS experience disruptions in care during pediatric‐to‐adult transitions and do not receive recommended survivorship care.
Kevin Shanchen Pu, Nicole Fernández‐Viña, Briana C. Martin‐Villa, Daniela Ramirez, Rebecca M. Lewinsohn, Mary Smith, Heidi Boynton, Lidia Schapira, Stephanie M. Smith   +8 more
wiley   +1 more source

Sequence features of retrotransposons allow for epigenetic variability

eLife, 2021
Transposable elements (TEs) are mobile genetic elements that make up a large fraction of mammalian genomes. While select TEs have been co-opted in host genomes to have function, the majority of these elements are epigenetically silenced by DNA ...
Kevin R Costello, Amy Leung, Candi Trac, Michael Lee, Mudaser Basam, J Andrew Pospisilik, Dustin E Schones   +6 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Gaps in obesity education - thematic narrative analysis from healthcare graduates: findings from the Erasmus Mundus EMINENT project

BMC Medical Education
Background Obesity is a complex, chronic disease with significant global health implications, yet its management remains underrepresented in medical and allied health education.
Tak Ying Louise Ko, Francisca Contreras, Carel W. le Roux, Werd Al-Najim   +3 more
doaj   +1 more source

Urologic Complications of Diabetes [PDF]

Diabetes Care, 2005
Diabetes and urologic diseases are very common health problems that markedly increase in prevalence and incidence with advancing age (1–3). Diabetes is associated with an earlier onset and increased severity of urologic diseases, resulting in costly and debilitating urologic complications.
Jeanette S, Brown, Hunter, Wessells, Michael B, Chancellor, Stuart S, Howards, Walter E, Stamm, Ann E, Stapleton, William D, Steers, Stephen K, Van Den Eeden, Kevin T, McVary   +8 more
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Metabolic health and vascular complications in type 1 diabetes [PDF]

, 2019
AIMS: Optimal glycaemic control benefits risk of microvascular and macrovascular complications in type 1 diabetes (T1DM) but the importance of other components of metabolic health is less certain, particularly in the context of routine clinical practice.
Misra, Shivani, Johnston, Desmond G, Godsland, Ian F, Bhattarai, Sandhya, Oliver, Nick   +4 more
core   +1 more source

Gestational diabetes mellitus: Association with maternal and neonatal complications [PDF]

, 2023
Background and objectives: Gestational diabetes mellitus (GDM) is known to be associated with pregnancy complications but there is limited evidence about the strength of these associations in recent clinical practice, especially after the introduction of
Akolekar, R., Giacchino, T., Ramadan, G., Karkia, R., Shah, Saadia, Gough, Andrew, Andrew Gough, Ranjit Akolekar, Rebecca Karkia, Ghada Ramadan, Tara Giacchino, Saadia Shah   +11 more
core   +1 more source

Vascular Regulation by Super Enhancer-Derived LINC00607

Frontiers in Cardiovascular Medicine, 2022
Vascular endothelial cells (ECs) play a pivotal role in whole body homeostasis. Recent advances have revealed enhancer-associated long non-coding RNAs (lncRNAs) as essential regulators in EC function.
Kiran Sriram, Kiran Sriram, Yingjun Luo, Dongqiang Yuan, Naseeb Kaur Malhi, Alonso Tapia, Alonso Tapia, Vishnu Amaram Samara, Vishnu Amaram Samara, Rama Natarajan, Rama Natarajan, Zhen Bouman Chen, Zhen Bouman Chen   +12 more
doaj   +1 more source