Results 51 to 60 of about 2,418,589 (310)

Opportunities for diabetes prevention: risk factors for diabetes and cost-effectiveness of interventions = Mogelijkheden voor diabetespreventie : risicofactoren voor diabetes en kosteneffectiviteit van interventies [PDF]

, 2010
Diabetes is already one of the most common chronic diseases in the Dutch population and a substantial further increase in the number of people with diabetes is expected in the near future.
Jacobs-van der Bruggen, M.A.M.
core  

Gastrointestinal Complications of Diabetes [PDF]

Endocrinology and Metabolism Clinics of North America, 2013
This review provides an overview of the vast gastrointestinal tract complications of diabetes that can occur from the mouth to the anus. The presentation, diagnosis, and management of gastrointestinal disorders, ranging from gastroparesis, celiac disease, and bacterial overgrowth to nonalcoholic fatty liver disease, are reviewed to heighten awareness ...
Brigid S, Boland, Steven V, Edelman, James D, Wolosin   +2 more
openaire   +2 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Vascular Regulation by Super Enhancer-Derived LINC00607

Frontiers in Cardiovascular Medicine, 2022
Vascular endothelial cells (ECs) play a pivotal role in whole body homeostasis. Recent advances have revealed enhancer-associated long non-coding RNAs (lncRNAs) as essential regulators in EC function.
Kiran Sriram, Kiran Sriram, Yingjun Luo, Dongqiang Yuan, Naseeb Kaur Malhi, Alonso Tapia, Alonso Tapia, Vishnu Amaram Samara, Vishnu Amaram Samara, Rama Natarajan, Rama Natarajan, Zhen Bouman Chen, Zhen Bouman Chen   +12 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Metabolic health and vascular complications in type 1 diabetes [PDF]

, 2019
AIMS: Optimal glycaemic control benefits risk of microvascular and macrovascular complications in type 1 diabetes (T1DM) but the importance of other components of metabolic health is less certain, particularly in the context of routine clinical practice.
Misra, Shivani, Johnston, Desmond G, Godsland, Ian F, Bhattarai, Sandhya, Oliver, Nick   +4 more
core   +1 more source

Targeted screening and identification of chlorhexidine as a pro-myogenic circadian clock activator

Stem Cell Research & Therapy, 2023
Background The circadian clock is an evolutionarily conserved mechanism that exerts pervasive temporal control in stem cell behavior. This time-keeping machinery is required for orchestrating myogenic progenitor properties in regenerative myogenesis that
Tali Kiperman, Weini Li, Xuekai Xiong, Hongzhi Li, David Horne, Ke Ma   +5 more
doaj   +1 more source

Can Weight Loss Improve the Cardiovascular Outcomes of Patients with Obesity and Obstructive Sleep Apnea?

Hearts, 2022
Cardiovascular events are the primary cause of mortality in patients with obstructive sleep apnea and obesity. The rising prevalence of obstructive sleep apnea in recent decades has been linked to increasing rates of obesity.
Ayyad Alruwaily, Heshma Alruwaili, John Garvey, Carel W. le Roux   +3 more
doaj   +1 more source