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Intestinal hyperemia in experimental diabetes mellitus

American Journal of Physiology-Gastrointestinal and Liver Physiology, 1987
Intestinal blood flows were measured using the radioactive microsphere technique in anesthetized, fasted (18–24 h) rats 4 wk after administration of streptozotocin (65 mg/kg body wt) or its vehicle. Blood flow was increased along the length of the small bowel in diabetic rats relative to normal animals.
R J, Korthuis   +5 more
openaire   +2 more sources

Characteristics of Proteinuria in Experimental Diabetes Mellitus

Biochemical Medicine and Metabolic Biology, 1994
An impairment of protein charge selectivity has been invoked to explain the initial anionic proteinuria in diabetic nephropathy. The aims of this work were to investigate charge and size protein perm-selectivity abnormalities in experimental diabetes and to monitor these changes over time after diabetes induction.
MORANO, Susanna   +7 more
openaire   +3 more sources

Fatty Acid Desaturation in Experimental Diabetes Mellitus

Diabetes, 1979
Microsomal fatty acid desaturation is defective in streptozotocin-induced experimental diabetes. This defect is correctable by insulin treatment. The electron transport chain needed for microsomal fatty acid desaturation was studied in liver microsomes of streptozotocin diabetic rats, and the defect was localized to the terminal desaturase enzyme ...
M G, Eck   +3 more
openaire   +2 more sources

Intestinal capillary filtration in experimental diabetes mellitus

American Journal of Physiology-Gastrointestinal and Liver Physiology, 1987
There is indirect evidence that indicates that intestinal transcapillary fluid and solute exchange is significantly altered in diabetes mellitus. To directly assess the dynamics of microvascular fluid and solute exchange in the small intestine (jejunum-ileum), we measured lymph flow, capillary pressure, capillary filtration coefficient, plasma and ...
R J, Korthuis, V H, Pitts, D N, Granger
openaire   +2 more sources

Microvascular Anastomotic Thrombosis in Experimental Diabetes Mellitus

Plastic and Reconstructive Surgery, 1997
An experimental model was developed to investigate the effects of glycemic control and pentoxifylline administration on microvascular anastomotic patency rates in streptozotocin-induced diabetic rats. Diabetes was confirmed by blood glucose levels of more than 300 mg/dl prior to administering insulin and/or pentoxifylline.
L B, Colen   +7 more
openaire   +2 more sources

Impaired Arteriolar Mechanotransduction in Experimental Diabetes Mellitus

Journal of Diabetes and its Complications, 1999
Decreased arteriolar distensibility in diabetes may impair signal transduction mechanisms that are required for converting a pressure stimulus into smooth muscle contraction. These studies aimed to determine if pressure-induced increases in arteriolar intracellular Ca(2+) are altered in diabetes and whether diabetes is associated with alterations in ...
G, Yu, H, Zou, R L, Prewitt, M A, Hill
openaire   +2 more sources

Experimental diabetes and its relation to diabetes mellitus

The American Journal of Medicine, 1955
Summary A few selected possibilities about the nature, causation and measurement of experimental diabetes have been outlined. A modest comprehension of these experimental experiences should be of some help in the management and study of the disease in man.
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Diabetes Mellitus in Man and Experimental Animals

Annals of Internal Medicine, 1967
Excerpt In a recent communication, scientists at the Jackson Laboratory in Bar Harbor, Me., reported a mutation (db) in an inbred strain of mice which is inherited as an autosomal-recessive trait a...
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Methods to Induce Experimental Diabetes Mellitus

2015
Dysfunction of the visceral tract has been considered for a long time to be the cause of diabetes mellitus. Bomskov in 1910 reported severe diabetic symptoms in dogs after cannulation of the ductus lymphaticus. This observation, however, could not be confirmed in later experiments (Vogel HG (1963), Unpublished data).
openaire   +2 more sources

Experimental Atherosclerosis and Diabetes Mellitus

1992
Although the production of arterial lesions in animals fed high fat and cholesterol diets had been described at the beginning of the 20th century, and experimental models of diabetes were available at the time Banting and Best isolated insulin in 1920, it was not until the 1940s that attempts were made to study the interaction of diabetes and ...
openaire   +1 more source

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