Results 111 to 120 of about 1,686,723 (381)

An explainable XGBoost-based approach towards assessing the risk of cardiovascular disease in patients with Type 2 Diabetes Mellitus [PDF]

arXiv, 2020
Cardiovascular Disease (CVD) is an important cause of disability and death among individuals with Diabetes Mellitus (DM). International clinical guidelines for the management of Type 2 DM (T2DM) are founded on primary and secondary prevention and favor the evaluation of CVD related risk factors towards appropriate treatment initiation.
arxiv  

The Placenta Regulates Intrauterine Fetal Growth via Exosomal PPARγ

Advanced Science, EarlyView.
The placenta expresses much higher levels of PPARγ than fetal adipose tissue. Trophoblastic exosomes transport PPARγ into fetal preadipocytes via fetoplacental circulation and thus regulate adipogenic genes distinct from endogenous PPARγ. Compromised placental PPARγ leads to fetal adipogenesis deficiency and intrauterine growth restriction, reversible ...
Xiaofang Luo, Biao Huang, Ping Xu, Hao Wang, Baozhen Zhang, Li Lin, Jiujiang Liao, Mingyu Hu, Xiyao Liu, Jiayu Huang, Yong Fu, Mark D. Kilby, Rodney E. Kellems, Xiujun Fan, Yang Xia, Philip N. Baker, Hongbo Qi, Chao Tong   +17 more
wiley   +1 more source

Global cognition and executive functions of older adults with type 1 diabetes mellitus without dementia

Journal of Diabetes Investigation
Aims/Introduction This study aimed to characterize the global cognition and executive functions of older adults with type 1 diabetes mellitus in comparison with type 2 diabetes mellitus.
Kaoru Nagasawa, Kimio Matsumura, Takayasu Uchida, Yuya Suzuki, Akihiro Nishimura, Minoru Okubo, Yukifusa Igeta, Tetsuro Kobayashi, Takashi Sakurai, Yasumichi Mori   +9 more
doaj   +1 more source

GABP Promotes Mesangial Cell Proliferation and Renal Fibrosis Through GLI1 in Diabetic Nephropathy

Advanced Science, EarlyView.
GABP is found to promote mesangial cell proliferation and ECM deposition through GLI1, while inhibiting GABP or GLI1 prevents the progression of DN by reducing ECM and fibrosis. The research results indicate that a potential therapeutic approach based on inhibiting mesangial cell proliferation and ECM accumulation can effectively treat DN, while GABP ...
Lei Du, Sijie Liu, Yinfei Lu, Dongxue Ren, Xiujuan Yu, Yue Hu, Tingting Yang, Qun Yang, Jingxian Ming, Jiawei Zhang, Xiaoxing Yin, Qian Lu   +11 more
wiley   +1 more source

A study on body mass index and its correlation with type 2 diabetes [PDF]

, 2017
Obesity and increases in body weight are among the most important risk factors for type 2 diabetes mellitus. Obesity contributes to the development of type 2 diabetes mellitus. Body mass index is also known as obesity index.
Gupta, Deepak, Gupta, Rameshwar Prasad, Jain, Madhu Kanta, Jain, Subhash Chand   +3 more
core   +1 more source

Enhancing Nonenzymatic Glucose Detection Through Cobalt‐Substituted Hafnia

Advanced Science, EarlyView.
Proposed nonenzymatic glucose sensor utilizes ultrathin hafnia films engineered with cobalt and oxygen vacancies, grown via chemical solution deposition. Cobalt atoms with multivalent state act as sites of oxidation for glucose and oxygen vacancies enhance charger transfer, allowing precise glucose oxidation with minimal interference from other ...
Jeonghyeon Oh, Avis Sin Hui Wee, Eun‐Byeol Park, Jaejin Hwang, Seon Je Kim, Hu Young Jeong, Myat Thet Khine, Pavan Pujar, Jaekwang Lee, Young‐Min Kim, Sunkook Kim   +10 more
wiley   +1 more source

Adiponectin as a Protective Factor Against the Progression Toward Type 2 Diabetes Mellitus in Postmenopausal Women. [PDF]

, 2015
Serum adiponectin levels have been suggested to be predictors of type 2 diabetes mellitus in diverse populations. However, the relationship between circulating adiponectin levels and the risk of development of type 2 diabetes in postmenopausal women has ...
Asadipooya, K, Assadi, M, Darabi, H, Dobaradaran, Sina, Kalantarhormozi, MR, Nabipour, Iraj, Ostovar, Afshin, Raeisi, Alireza, Vahdat, K   +8 more
core   +6 more sources

Intestinal Gastrin/CCKBR Axis Protects against Type 2 Diabetes by Reducing Intestinal Glucose Absorption through the PI3K/Akt/eIF4B Signaling Pathway

Advanced Science, EarlyView.
In intestinal epithelial cells, Gastrin/CCKBR stimulation prevents high glucose‐stimulated SGLT1 (SLC5A1) and GLUT2 (SLCA2) expressions, via the PI3K/AKT/eIF4B signaling pathway, with facilitatory effects on the secretion of incretins, which could be therapeutic targets for clinical treatment in T2D.
Xue Liu, Xing Liu, Yunpeng Liu, Anxiong Long, Wei Liu, Shiyun Sun, Shuaibing Lu, Xianxian Wu, Xiaodi Jia, Pedro A Jose, Qiang Wei, Xiaoliang Jiang, Haizeng Zhang, Zhiwei Yang   +13 more
wiley   +1 more source

Type 2 Diabetes Mellitus and Cognitive Impairment

Acta Medica Indonesiana, 2021
Type 2 diabetes mellitus (T2DM) is strongly associated with lower performance on multiple domains of cognitive function and with structural abnormalities of the brain.
Johanda Damanik, Em Yunir
doaj  

Insulin therapy of type 2 diabetes mellitus

Mìžnarodnij Endokrinologìčnij Žurnal, 2020
Basal insulin therapy in combination with oral hypoglycemic drugs has a special effect on fasting blood glucose. It is a simple way of introducing insulin therapy in patients with type 2 diabetes mellitus subjected to further prandial insulin therapy ...
G.F. Gendeleka, A.N. Gendeleka
doaj   +1 more source