Results 61 to 70 of about 326,550 (210)

Tubulointerstitial injury and proximal tubule albumin transport in early diabetic nephropathy induced by type 1 diabetes mellitus [PDF]

, 2017
A decrease in the tubular expression of albumin endocytic transporters megalin and cubilin has been associated with diabetic nephropathy (DN), but there are no comprehensive studies to date relating early tubulointerstitial injury and the effect of the ...
Bahamonde, Javiera, Ezquer, Fernando, Ezquer, Marcelo, Giraud Billoud, Maximiliano German   +3 more
core  

Randomized multicentre pilot study of sacubitril/valsartan versus irbesartan in patients with chronic kidney disease: United Kingdom Heart and Renal Protection (HARP)- III—rationale, trial design and baseline data [PDF]

, 2016
BACKGROUND: Patients with chronic kidney disease (CKD) are at risk of progression to end-stage renal disease and cardiovascular disease. Data from other populations and animal experiments suggest that neprilysin inhibition (which augments the ...
Baigent, C., Baxter, A., Bethel, A., Bowman, L., Brunskill, N., Cockwell, P., Dayanandan, R., Emberson, J., Haynes, R., Herrington, W.G., Hill, M., Judge, P.K., Kalra, P.A., Knott, C., Landray, M.J., McMurray, John J., Murphy, K., Roderick, P., Staplin, N., Storey, B.C., Taal, M., Tomson, C., Wheatley, K., Wheeler, D.C.   +23 more
core   +1 more source

Sevelamer, a phosphate-binding resin with beneficial effect in diabetic kidney disease; a modern paradigm shift [PDF]

, 2014
The proportion of individuals diagnosed with diabetes mellitus is increasing throughout the world, which sequentially drives upward the global frequency of diabetic kidney disease (1, 2). Diabetes is a costly and deadly disease.
Baradaran, Azar., Beladi Mousavi, Seyed seifollah., Mardani, Saeed., Shahbazian, Heshmatollah., Tamadon, Mohammad Reza.   +4 more
core  

Finerenone: From the Mechanism of Action to Clinical Use in Kidney Disease

Pharmaceuticals
Diabetic kidney disease is a frequent microvascular complication of diabetes and is currently the leading cause of chronic kidney disease and end-stage kidney disease worldwide.
Nejc Piko, Sebastjan Bevc, Radovan Hojs, Robert Ekart   +3 more
doaj   +1 more source

Deletion of diacylglycerol-responsive TRPC genes attenuates diabetic nephropathy by inhibiting activation of the TGFβ1 signaling pathway [PDF]

, 2017
TRPC6 plays a critical role in proteinuric kidney diseases, and TRPC3 is involved in tubulointerstitialdamage and renal fibrosis in obstructed kidneys. Podocyte loss is a characteristic event in diabetic nephropathy(DN).
Birnbaumer, Lutz, He, Xiju, Li, Shoutian, Liao, Yanhong, Liu, Benju, Xu, Benke   +5 more
core  

Pharmacologic approaches against advanced glycation end products (ages) in diabetic cardiovascular disease [PDF]

, 2015
Advanced Glycation End-Products (AGEs) are signaling proteins associated to several vascular and neurological complications in diabetic and non-diabetic patients.
Avtaar Singh, Sanjeet Singh, Chello, Massimo, DI DOMENICO, Fabio, Nappi, Francesco, Nenna, Antonio, Spadaccio, Cristiano, Sutherland, Fraser W   +6 more
core   +2 more sources

Progress in research on correlation between pathological characteristics and prognosis of diabetic kidney disease

Linchuang shenzangbing zazhi, 2020
As one of the major complications of diabetes,diabetic kidney disease is the leading cause for end-stage renal failure.Proteinuria and serum creatinine are still the main clinical indicators for judging the occurrence and prognosis of diabetic kidney ...
ZHONG Ting, DONG Wei, LI Rui-zhao, LIANG Xin-ling   +3 more
doaj  

Impact of individual microvascular disease on the risks of macrovascular complications in type 2 diabetes: a nationwide population-based cohort study

Cardiovascular Diabetology, 2023
Background This study compared the risks of cardiovascular morbidity and mortality between patients with type 2 diabetes (T2D) with and without microvascular diseases, and between matched patients with microvascular diseases.
Fu-Shun Yen, James Cheng-Chung Wei, Ying-Hsiu Shih, Chih-Cheng Hsu, Chii-Min Hwu   +4 more
doaj   +1 more source

End stage renal disease and survival in people with diabetes:a national database linkage study [PDF]

, 2014
© The Author 2014. Published by Oxford University Press on behalf of the Association of Physicians. Funding This work was supported by the Wellcome Trust through the Scottish Health Informatics Programme (SHIP).
,, ,, Bell, S., Brady, I., Colhoun, H. M., Conway, B., Fletcher, E. H., Halbesma, N., Joss, N., Leese, G., Levin, D., Lindsay, R. S., Livingstone, S., Looker, H. C., Mcknight, J., Metcalfe, W., Pearson, D., Philip, S., Sattar, N., Traynor, J. P., Wild, S.   +20 more
core   +7 more sources

Hydrogen Sulfide: Recent Progression and Perspectives for the Treatment of Diabetic Nephropathy

Molecules, 2019
Diabetic kidney disease develops in approximately 40% of diabetic patients and is a major cause of chronic kidney diseases (CKD) and end stage kidney disease (ESKD) worldwide.
Hai-Jian Sun, Zhi-Yuan Wu, Lei Cao, Meng-Yuan Zhu, Teng-Teng Liu, Lei Guo, Ye Lin, Xiao-Wei Nie, Jin-Song Bian   +8 more
doaj   +1 more source