Results 61 to 70 of about 331,534 (287)

Serum C3 as an early-warning biomarker for renal pathological progression in DKD

Frontiers in Immunology
ObjectiveTo investigate the association between serum complement component 3 (C3) levels and renal pathological injury across different estimated glomerular filtration rate (eGFR) strata in patients with diabetic kidney disease (DKD) and evaluate its ...
Donghong Ma, Donghong Ma, Senle Dai, Senle Dai, Tongtong Dai, Tongtong Dai, Dandan Wang, Dandan Wang, Xue Shan, Jiao Zhang, Jiao Zhang, Jingjing Shi, Yulong Hou, Wenchao Li, Wenchao Li, Minghao Guo   +15 more
doaj   +1 more source

The construction of a TCM knowledge graph and application of potential knowledge discovery in diabetic kidney disease by integrating diagnosis and treatment guidelines and real-world clinical data

Frontiers in Pharmacology, 2023
Background: The complexity and rapid progression of lesions in diabetic kidney disease pose significant challenges for clinical diagnosis and treatment.
Xiaoliang Zhao, Yifei Wang, Penghui Li, Julia Xu, Yao Sun, Yao Sun, Moyan Qiu, Guoming Pang, Tiancai Wen, Tiancai Wen   +9 more
doaj   +1 more source

Microbiota signatures in type-2 diabetic patients with chronic kidney disease - A Pilot Study [PDF]

, 2019
The human microbiota is paramount for normal host physiology. Altered host-microbiome interactions are part of the pathogenesis of numerous common ailments.
Chifiriuc, Mariana Carmen, Gradisteanu, Gratiela P., Petcu, Laura, Picu, Ariana, Salmen, Teodor, Serafinceanu, Cristian, Stefan, Diana S., Stoian, Anca P., Stoica, Roxana A., Suceveanu, Adrian P.   +9 more
core   +1 more source

Apolipoprotein L1 gene variants associate with prevalent kidney but not prevalent cardiovascular disease in the Systolic Blood Pressure Intervention Trial. [PDF]

, 2015
Apolipoprotein L1 gene (APOL1) G1 and G2 coding variants are strongly associated with chronic kidney disease (CKD) in African Americans (AAs). Here APOL1 association was tested with baseline estimated glomerular filtration rate (eGFR), urine albumin ...
Bild, Diane E, Divers, Jasmin, Freedman, Barry I, Hawfield, Amret T, Kaysen, George A, Kimmel, Paul L, Langefeld, Carl D, Pajewski, Nicholas M, Raj, Dominic S, Reboussin, David M, Ricardo, Ana C, Rocco, Michael V, Sedor, John R, Systolic Blood Pressure Intervention Trial (SPRINT), Wright, Jackson T   +14 more
core   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Colquhounia root tablet improves diabetic kidney disease by regulating epithelial-mesenchymal transition via the PTEN/PI3K/AKT pathway

Frontiers in Pharmacology
BackgroundDiabetic kidney disease (DKD) is a severe microvascular complication of diabetes mellitus that can lead to end-stage renal disease. Colquhounia root tablet (CRT) has shown therapeutic potential in treating DKD, but its efficacy and underlying ...
Donghong Ma, Donghong Ma, Jiao Zhang, Lu Du, Jingjing Shi, Zhaoyan Liu, Zhaoyan Liu, Jilin Qin, Jilin Qin, Xiaoxiao Chen, Xiaoxiao Chen, Minghao Guo   +11 more
doaj   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Management of diabetic kidney disease: Recent advances

Indian Journal of Endocrinology and Metabolism, 2013
Diabetic kidney disease, in present days, is being recognized as the commonest cause of end stage renal disease. Though there is no absolute therapy for diabetic kidney disease, decades of hard work has recognized some modifiable factors that can prevent
Pankaj Agarwal
doaj   +1 more source

Renal resistive index as a marker of histopathological damage in diabetic and non-diabetic chronic kidney disease

The Egyptian Journal of Radiology and Nuclear Medicine, 2023
Background Chronic kidney disease is a worldwide public health problem with diabetes being the leading cause. Renal resistive index derived by Duplex Doppler sonography, has been in use clinically to examine intrarenal hemodynamic abnormalities. However,
Theertha Kuttancheri, Sudha Kiran Das, Manjunath Sanjeeva Shetty, Suchitha Satish, B. Bathrenathh   +4 more
doaj   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source