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Capturing the inflammatory landscape within kidney compartments of human diabetic kidney disease: a digital spatial profiling study. [PDF]
Front Endocrinol (Lausanne)Elhusseiny KM +7 more
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Clinical Cornerstone, 2003
As the epidemic of diabetes spreads so does the number of patients at risk for developing diabetic nephropathy, which occurs in 20% to 40% of all diabetic patients. Indeed, diabetes is the most common cause of end-stage renal disease (ESRD) in the United States, accounting for > 40% of patients starting renal replacement therapy each year ...
Mark E, Molitch +5 more
openaire +4 more sources
As the epidemic of diabetes spreads so does the number of patients at risk for developing diabetic nephropathy, which occurs in 20% to 40% of all diabetic patients. Indeed, diabetes is the most common cause of end-stage renal disease (ESRD) in the United States, accounting for > 40% of patients starting renal replacement therapy each year ...
Mark E, Molitch +5 more
openaire +4 more sources
Medical Clinics of North America, 1997
Diabetic nephropathy accounts for almost a third of all causes of ESRD. Microalbuminuria screening among diabetics can offer early detection of incipient nephropathy. Aggressive treatment with ACE inhibitors may delay the onset of overt renal failure or delay its progression.
CASTELLINO, Pietro +2 more
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Diabetic nephropathy accounts for almost a third of all causes of ESRD. Microalbuminuria screening among diabetics can offer early detection of incipient nephropathy. Aggressive treatment with ACE inhibitors may delay the onset of overt renal failure or delay its progression.
CASTELLINO, Pietro +2 more
openaire +6 more sources
Current Opinion in Internal Medicine, 2003
Diabetic nephropathy is the single most common disorder leading to renal failure. Its annual incidence has more than doubled in the past decade to reach 44% of all end-stage renal disease, despite recent therapeutic advances. Thus, research into diabetic nephropathy pathophysiology that could lead to new treatment approaches is urgently needed and this
M Luiza, Caramori, Michael, Mauer
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Diabetic nephropathy is the single most common disorder leading to renal failure. Its annual incidence has more than doubled in the past decade to reach 44% of all end-stage renal disease, despite recent therapeutic advances. Thus, research into diabetic nephropathy pathophysiology that could lead to new treatment approaches is urgently needed and this
M Luiza, Caramori, Michael, Mauer
openaire +2 more sources
Best Practice & Research Clinical Endocrinology & Metabolism, 1999
Diabetic nephropathy remains a leading cause of end-stage renal disease (ESRD) in western societies, accounting for over one-third of all patients beginning renal replacement therapy. Patients with Type 2 diabetes comprise the largest and fastest-growing single disease group requiring renal support therapy.
H A, Ibrahim, J P, Vora
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Diabetic nephropathy remains a leading cause of end-stage renal disease (ESRD) in western societies, accounting for over one-third of all patients beginning renal replacement therapy. Patients with Type 2 diabetes comprise the largest and fastest-growing single disease group requiring renal support therapy.
H A, Ibrahim, J P, Vora
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Disease-a-Month, 1993
Diabetic nephropathy occurs in approximately 35% of all diabetic patients, both insulin and non-insulin dependent. It accounts for the largest proportion increase of all diseases as a cause for endstage renal disease in the United States. Certain populations, i.e., Pima Indians and Mexican and black Americans, have a higher propensity for developing ...
G L, Bakris, J H, Stein
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Diabetic nephropathy occurs in approximately 35% of all diabetic patients, both insulin and non-insulin dependent. It accounts for the largest proportion increase of all diseases as a cause for endstage renal disease in the United States. Certain populations, i.e., Pima Indians and Mexican and black Americans, have a higher propensity for developing ...
G L, Bakris, J H, Stein
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Pyroptosis in diabetes and diabetic nephropathy
Clinica Chimica Acta, 2022Pyroptosis is identified as a pro-inflammatory programmed cell death, mediated by gasdermins (GSDMs) family of proteins accompanied by pro-inflammatory signals release. As essential players in innate immunity, inflammasomes are intracellular protein complexes which cleave gasdermin D (GSDMD), forming structurally stable pores in the cell membrane ...
Zhaohui, Cao +6 more
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2012
The most common cause of end stage renal disease (ESRD) requiring dialysis is diabetes. Both environmental and genetic factors have been postulated as the risk factors of Diabetic Nephropathy (DN). Hyperglycemia-induced metabolic and hemodynamic pathways are recognized to be mediators of kidney injury. Multiple biochemical pathways have been postulated
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The most common cause of end stage renal disease (ESRD) requiring dialysis is diabetes. Both environmental and genetic factors have been postulated as the risk factors of Diabetic Nephropathy (DN). Hyperglycemia-induced metabolic and hemodynamic pathways are recognized to be mediators of kidney injury. Multiple biochemical pathways have been postulated
openaire +2 more sources