Results 61 to 70 of about 37,693 (353)

The clinical epidemiology of young adults starting renal replacement therapy in the UK:presentation, management and survival using 15 years of UK Renal Registry data [PDF]

, 2017
Background: Clinical epidemiology data for young adults on renal replacement therapy (RRT) is lacking. Whilst mostly transplanted, they have an increased risk of graft loss during young adulthood. Methods: We combined the UK Renal Registry paediatric and
Ben-Shlomo, Yoav, Caskey, Fergus, Casula, Anna, Hamilton, Alexander, Inward, Carol   +4 more
core   +2 more sources

SETDB2 Mitigates Podocyte Dysfunction in Diabetic Kidney Disease Through Epigenetic Silencing of SMAD3

Advanced Science, EarlyView.
SETDB2 epigenetically represses Smad3 transcription by increasing H3K9me3 enrichment at its promoter, thereby mitigating podocyte dysfunction in DKD. The transcription factor TCF21 binds directly to the Setdb2 promoter and enhances its expression in podocytes. Abstract Podocyte dysfunction represents both an early pathological hallmark and a key driver
Lanfang Li, Shimin Jiang, Qi Jin, Peng Qu, Yingjie Guo, Xushan Lan, Xinyu Li, Cuiting Sun, Sinan Ai, Xin Li, Weiliang Sun, Jing Guo, Wenge Li, Liang Peng, Lihong Liu   +14 more
wiley   +1 more source

A machine learning model for predicting worsening renal function using one‐year time series data in patients with type 2 diabetes

Journal of Diabetes Investigation
Background and Aims To prevent end‐stage renal disease caused by diabetic kidney disease, we created a predictive model for high‐risk patients using machine learning.
Mari Watanabe, Shu Meguro, Kaiken Kimura, Michiaki Furukoshi, Tsuyoshi Masuda, Makoto Enomoto, Hiroshi Itoh   +6 more
doaj   +1 more source

Mesenchymal stem cells modulate albumin-induced renal tubular inflammation and fibrosis. [PDF]

, 2014
Bone marrow-derived mesenchymal stem cells (BM-MSCs) have recently shown promise as a therapeutic tool in various types of chronic kidney disease (CKD) models. However, the mechanism of action is incompletely understood.
Chan, LYY, Lai, KN, Leung, JCK, Li, RX, Lian, Q, Lin, M, Tang, SCW, Tse, HF, Wong, DWL, Wu, HJ, Yiu, WH, Zhang, Y   +11 more
core   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Novel thinking of renal pathology on the diagnosis and prognosis of diabetic nephropathy

Linchuang shenzangbing zazhi, 2021
Diabetes mellitus（DM）has been a great challenge to human health. is As one of the most important complications, diabetic nephropathy（DN）is a major cause of end-stage renal disease（ESRD）.
Zhou Ting, Wang Nian-song, Fan Ying
doaj  

Doença Renal na Região Autónoma da Madeira: Experiência de Vinte e Sete Anos de Biópsias de Rim Nativo [PDF]

, 2014
Introduction: Renal biopsy plays an essential role either in the diagnosis or in the prognosis of patients with renal disease. In order to assess its epidemiology and evolution in Madeira Islands, we analysed twenty-seven years of native kidney biopsies.
Alves Teixeira, Araújo, J, Brinca, A, Carvalho, F, Durães, JM, Galvão, MJ, Gonçalves, AM, Resende, L, Rodrigues, F, Rosa, N, Silva, G, Viana, H, Vieira, P   +12 more
core   +1 more source

Multicentric validation of proteomic biomarkers in urine specific for diabetic nephropathy [PDF]

, 2010
Background: Urine proteome analysis is rapidly emerging as a tool for diagnosis and prognosis in disease states. For diagnosis of diabetic nephropathy (DN), urinary proteome analysis was successfully applied in a pilot study.
A Kottgen, Alaa Alkhalaf, AS Levey, BA Julian, BA Julian, Bart Janssen, Beate Tiran, BJ Williams, Brigitte M. Winklhofer-Roob, CD Stehouwer, Christine Fischer, D Fliser, D McLerran, D Theodorescu, DM Good, DM Good, DM Good, DM Good, EM Weissinger, F Goodsaid, F Huang, Gerjan J. Navis, H Mischak, Harald Mischak, Harald Sourij, Henk J. G. Bilo, HH Parving, Ivan Rychlík, J Jantos-Siwy, JK Snell-Bergeon, JM DeLeo, Johannes M. Roob, K Rossing, K Rossing, K Rossing, KA Baggerly, Karel Medek, Kasper Rossing, M Girolami, M Haubitz, MA Knepper, Marie Cerna, Massimo Federici, N Neuhoff, O Soylemezoglu, P Lescuyer, P Zürbig, P Zürbig, Peter Rossing, Petra Zürbig, PV Rao, S Decramer, S Schaub, S Wittke, SA Varghese, Sebastian Fuchs, Stephan J. L. Bakker, TY Wong, Y Benjamini, YM Smulders, ZR Yang, ZR Yang   +61 more
core   +5 more sources

pdx1 Knockout Leads to a Diabetic Nephropathy– Like Phenotype in Zebrafish and Identifies Phosphatidylethanolamine as Metabolite Promoting Early Diabetic Kidney Damage [PDF]

, 2022
Lucas M. Wiggenhauser, Lena Metzger, Katrin Bennewitz, Silas Soleymani, Mike Boger, Christoph T. Tabler, Ingrid Haußer, Carsten Sticht, Paulus Wohlfart, Nadine Volk, Elena Heidenreich, Michael Buettner, Hans‐Peter Hammes, Jens Krøll   +13 more
openalex   +1 more source

Modulation of Network Plasticity Opens Novel Therapeutic Possibilities in Cancer, Diabetes, and Neurodegeneration

Advanced Science, EarlyView.
Plasticity changes of molecular networks form a cellular learning process. Signaling network plasticity promotes cancer, metastasis, and drug resistance development. 55 plasticity‐related cancer drug targets are listed (20 having already approved drugs, 9 investigational drugs, and 26 being drug target candidates).
Márk Kerestély, István Narozsny, Levente Szarka, Daniel V. Veres, Peter Csermely, Dávid Keresztes   +5 more
wiley   +1 more source