Results 101 to 110 of about 432,036 (307)

Immunoglobulin heavy constant gamma 1 silencing decreases tonicity‐responsive enhancer‐binding protein expression to alleviate diabetic nephropathy

Journal of Diabetes Investigation
Aims/Introduction The molecular mechanisms of diabetic nephropathy (DN) are poorly identified. However, the advantage of an increasing amount on microarray data of diabetic nephropathy intrigued us to explore the mechanisms based on bioinformatics ...
Qibo Hu, Qingxiao Yang, Hang Gao, Jing Tian, Guanghua Che   +4 more
doaj   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes.

PLoS ONE, 2018
To explore novel genetic loci for diabetic nephropathy, we performed genome-wide association studies (GWAS) for diabetic nephropathy in Japanese patients with type 2 diabetes. We analyzed the association of 5,768,242 single nucleotide polymorphisms (SNPs)
Makiko Taira, Minako Imamura, Atsushi Takahashi, Yoichiro Kamatani, Toshimasa Yamauchi, Shin-Ichi Araki, Nobue Tanaka, Natalie R van Zuydam, Emma Ahlqvist, Masao Toyoda, Tomoya Umezono, Koichi Kawai, Masahito Imanishi, Hirotaka Watada, Daisuke Suzuki, Hiroshi Maegawa, Tetsuya Babazono, Kohei Kaku, Ryuzo Kawamori, SUMMIT Consortium, Leif C Groop, Mark I McCarthy, Takashi Kadowaki, Shiro Maeda   +23 more
doaj   +1 more source

Pathogenesis and Treatment of Chronic Kidney Disease: A Review of Our Recent Basic and Clinical Data

Kidney & Blood Pressure Research, 2014
Chronic kidney disease (CKD) is a worldwide public health problem that affects millions of people from all racial and ethnic groups. At end of 2013, over 300,000 Japanese patients had maintenance dialysis therapy (JSDT). In Japan, the major causes of end
Yasuhiko Tomino
doaj   +1 more source

Growth factors in the pathogenesis of diabetic nephropathy

, 2011
Despite the growing toll of diabetic nephropathy on public health [1], the current armamentarium for treatment and prevention of the disease remains limited to the blocking of the renin-angiotensin-aldosterone system (RAAS) and the control of ...
Khoury C.C., Ziyadeh F.N.
core  

Ethnic variations in the prevalence of diabetic retinopathy in people with diabetes attending screening in the United Kingdom (DRIVE UK). [PDF]

, 2012
AIMS: To compare the prevalence of diabetic retinopathy (DR) in people of various ethnic groups with diabetes in the United Kingdom (UK). METHODS: The Diabetic Retinopathy In Various Ethnic groups in UK (DRIVE UK) Study is a cross-sectional study on the ...
Gulliford Martin C., Hiten Dodhia, Gupta Bhaskar, Sobha Sivaprasad, Evans Jennifer R., Jennifer R Evans, Evans, Jennifer R., Mohamed Moin, Moin Mohamed, Dinesh Nagi, Sivaprasad, Sobha, Nagi Dinesh, Evans, Jennifer R, Dodhia Hiten, Gulliford, Martin C., Bhaskar Gupta, Gulliford, Martin C, Dodhia, Hiten, Sivaprasad Sobha, Gupta, Bhaskar, Martin C Gulliford, Mohamed, Moin, Nagi, Dinesh   +22 more
core   +1 more source

Targeting Renal IGFBP7 With Tetrahedral Framework Nucleic Acid‐Delivered siRNA Alleviates Acute Kidney Injury

iNew Medicine, EarlyView.
A tFNA‐based siRNA delivery system targeting IGFBP7 effectively silences IGFBP7 expression and attenuates renal dysfunction, tubular injury, and cell death in both septic (CLP) and ischemic (I/R) murine models of acute kidney injury. ABSTRACT Objective Acute kidney injury (AKI) is a common and serious clinical condition, yet effective targeted ...
Shao‐qi Wu, Ying‐ying Gao, Meng‐yi Jia, Yu‐Hao Liu, Qian Zhou, Dong Liu, Yu Ren, Yu‐jie Liu, Feng‐he Li, Ya‐ru Yang, Jie Wang, Jia‐gen Wen   +11 more
wiley   +1 more source

Age at onset of type 1 diabetes between puberty and 30 years old is associated with increased diabetic nephropathy risk

Scientific Reports
Diabetic nephropathy is a critical complication of patients with type 1 diabetes, while epidemiological studies were scarce among Asian countries.
Yen-Bo Lin, Taiwan Diabetes Registry Study Group, Tien-Jyun Chang   +2 more
doaj   +1 more source

Effects of N-acetyl cysteine on serum lipoprotein (a) and proteinuria in type 2 diabetic patients [PDF]

, 2013
Background: About 30-40 of diabetic patients who developed nephropathy have lipoprotein disorders, especially lipoprotein a Lp(a), which is related to atherosclerosis.
Forouzan Ganji, Ganji, F., Rouhi, H., Rouhi-Boroujeni, H., Hamid Rouhi   +4 more
core   +2 more sources

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

iNew Medicine, EarlyView.
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang, Xinyan Li, Honglu Shi, Gaolei Song, Zhifu Xie, Jingya Li   +5 more
wiley   +1 more source