Results 91 to 100 of about 111,907 (307)
Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials
iNew Medicine, EarlyView.ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong +5 more
wiley +1 more source
Type-2 Diabetic Nephropathy in Japan : From Bench to Bedside /
, 2001 Type-2 diabetic nephropathy is one of the major long-term microvascular complications occurring in nearly 40% of diabetic patients in Japan. The purpose of this book is to review recent work on the genetic background, pathogenesis and treatment of this ...
Tomino, Y.
core
iNew Medicine, EarlyView.ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little +12 more
wiley +1 more source
iNew Medicine, EarlyView.A tFNA‐based siRNA delivery system targeting IGFBP7 effectively silences IGFBP7 expression and attenuates renal dysfunction, tubular injury, and cell death in both septic (CLP) and ischemic (I/R) murine models of acute kidney injury. ABSTRACT Acute kidney injury (AKI) is a common and serious clinical condition, yet effective targeted therapies remain ...
Shao‐qi Wu +11 more
wiley +1 more source
Journal of Diabetes InvestigationAims/Introduction The molecular mechanisms of diabetic nephropathy (DN) are poorly identified. However, the advantage of an increasing amount on microarray data of diabetic nephropathy intrigued us to explore the mechanisms based on bioinformatics ...
Qibo Hu +4 more
doaj +1 more source
Experimental and Clinical Endocrinology & Diabetes, 2021 Ludwig, Merker +4 more
openaire +2 more sources
Growth factors in the pathogenesis of diabetic nephropathy
, 2011 Despite the growing toll of diabetic nephropathy on public health [1], the current armamentarium for treatment and prevention of the disease remains limited to the blocking of the renin-angiotensin-aldosterone system (RAAS) and the control of ...
Khoury C.C., Ziyadeh F.N.
core
, 2012 Objectives: National guidelines recommend angiotensin- converting enzyme inhibitors (ACE15) or angiotensin receptor blockers (ARBs) therapy for diabetic patients with hypertension and/or proteinuria to hinder renal disease progression. However, little is
YEH, HSENG-LONG;HUANG, LOREEN LI-YING;SU, SYI;YANG, MING-CHIN +1 more
core +1 more source
Effects of N-acetyl cysteine on serum lipoprotein (a) and proteinuria in type 2 diabetic patients [PDF]
, 2013 Background: About 30-40 of diabetic patients who developed nephropathy have lipoprotein disorders, especially lipoprotein a Lp(a), which is related to atherosclerosis.
Forouzan Ganji +4 more
core +1 more source
Journal of Applied Toxicology, EarlyView.ABSTRACT Heavy metal exposure is known to have various effects on renal function and blood glucose regulation. The main objective of this study was to evaluate the effects of cement dust and some metal (cadmium, manganese, nickel, and zinc) exposure on blood glucose and renal function parameters in male cement plant workers.
Duygu Seyhan Erdoğan +5 more
wiley +1 more source