Results 111 to 120 of about 112,312 (307)

A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes.

PLoS ONE, 2018
To explore novel genetic loci for diabetic nephropathy, we performed genome-wide association studies (GWAS) for diabetic nephropathy in Japanese patients with type 2 diabetes. We analyzed the association of 5,768,242 single nucleotide polymorphisms (SNPs)
Makiko Taira, Minako Imamura, Atsushi Takahashi, Yoichiro Kamatani, Toshimasa Yamauchi, Shin-Ichi Araki, Nobue Tanaka, Natalie R van Zuydam, Emma Ahlqvist, Masao Toyoda, Tomoya Umezono, Koichi Kawai, Masahito Imanishi, Hirotaka Watada, Daisuke Suzuki, Hiroshi Maegawa, Tetsuya Babazono, Kohei Kaku, Ryuzo Kawamori, SUMMIT Consortium, Leif C Groop, Mark I McCarthy, Takashi Kadowaki, Shiro Maeda   +23 more
doaj   +1 more source

Pathogenesis and Treatment of Chronic Kidney Disease: A Review of Our Recent Basic and Clinical Data

Kidney & Blood Pressure Research, 2014
Chronic kidney disease (CKD) is a worldwide public health problem that affects millions of people from all racial and ethnic groups. At end of 2013, over 300,000 Japanese patients had maintenance dialysis therapy (JSDT). In Japan, the major causes of end
Yasuhiko Tomino
doaj   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

Immunization of AGE-modified albumin inhibits diabetic nephropathy progression in diabetic mice [PDF]

, 2015
Musthika Wida Mashitah,1 Nurona Azizah,1 Nur Samsu,2 Muhammad Rasjad Indra,1 Muhammad Bilal,3 Meti Verdian Yunisa,4 Amildya Dwi Arisanti41Department of Biomedicine, Faculty of Medicine, Brawijaya University, Malang, 2Department of Internal Medicine ...
Mashitah MW, Arisanti AD, Azizah N, Bilal M, Yunisa MV, Indra MR, Samsu N   +6 more
core  

Ethnic variations in the prevalence of diabetic retinopathy in people with diabetes attending screening in the United Kingdom (DRIVE UK). [PDF]

, 2012
AIMS: To compare the prevalence of diabetic retinopathy (DR) in people of various ethnic groups with diabetes in the United Kingdom (UK). METHODS: The Diabetic Retinopathy In Various Ethnic groups in UK (DRIVE UK) Study is a cross-sectional study on the ...
Gulliford Martin C., Hiten Dodhia, Gupta Bhaskar, Sobha Sivaprasad, Evans Jennifer R., Jennifer R Evans, Evans, Jennifer R., Mohamed Moin, Moin Mohamed, Dinesh Nagi, Sivaprasad, Sobha, Nagi Dinesh, Evans, Jennifer R, Dodhia Hiten, Gulliford, Martin C., Bhaskar Gupta, Gulliford, Martin C, Dodhia, Hiten, Sivaprasad Sobha, Gupta, Bhaskar, Martin C Gulliford, Mohamed, Moin, Nagi, Dinesh   +22 more
core   +1 more source

Targeting Renal IGFBP7 With Tetrahedral Framework Nucleic Acid‐Delivered siRNA Alleviates Acute Kidney Injury

iNew Medicine, EarlyView.
A tFNA‐based siRNA delivery system targeting IGFBP7 effectively silences IGFBP7 expression and attenuates renal dysfunction, tubular injury, and cell death in both septic (CLP) and ischemic (I/R) murine models of acute kidney injury. ABSTRACT Objective Acute kidney injury (AKI) is a common and serious clinical condition, yet effective targeted ...
Shao‐qi Wu, Ying‐ying Gao, Meng‐yi Jia, Yu‐Hao Liu, Qian Zhou, Dong Liu, Yu Ren, Yu‐jie Liu, Feng‐he Li, Ya‐ru Yang, Jie Wang, Jia‐gen Wen   +11 more
wiley   +1 more source

Does curcumin or metformin attenuate oxidative stress and diabetic nephropathy in rats? [PDF]

, 2019
Background: Since the importance of oxidative stress in the development of diabetic nephropathy (DN) has previously been established, the therapeutic effects of various natural antioxidant agents or synthetic drugs have so far been investigated ...
Mohammad Taghi Goodarzi, Soheila Asadi, Mohammad Hashemnia, Jamshid Karimi, Iraj Khodadadi   +4 more
core   +1 more source

Age at onset of type 1 diabetes between puberty and 30 years old is associated with increased diabetic nephropathy risk

Scientific Reports
Diabetic nephropathy is a critical complication of patients with type 1 diabetes, while epidemiological studies were scarce among Asian countries.
Yen-Bo Lin, Taiwan Diabetes Registry Study Group, Tien-Jyun Chang   +2 more
doaj   +1 more source

Nondiabetic kidney diseases in type 2 diabetic patients

Kidney Research and Clinical Practice, 2013
Background: The aim of this study was to evaluate the clinical characteristics of nondiabetic nephropathy in type 2 diabetes mellitus patients and to find a clinical significance of renal biopsy and immunosuppressive treatment in such a patient. Methods:
Ye Jin Kim, Yoo Hyung Kim, Ki Dae Kim, Kang Ryun Moon, Jae Ho Park, Bo Mi Park, Hyewon Ryu, Dae Eun Choi, Ki Ryang Na, Kwang Sun Suh, Kang Wook Lee, Young Tai Shin   +11 more
doaj   +1 more source

Glycemic Regulation and Renal Function by Heavy Metal Exposure: A Cross‐Sectional Analysis on Cement Plant Workers

Journal of Applied Toxicology, EarlyView.
ABSTRACT Heavy metal exposure is known to have various effects on renal function and blood glucose regulation. The main objective of this study was to evaluate the effects of cement dust and some metal (cadmium, manganese, nickel, and zinc) exposure on blood glucose and renal function parameters in male cement plant workers.
Duygu Seyhan Erdoğan, Fatma Bozdag, Fatıma Betül Topcu, Osman Burak Demirbas, Sultan Pinar Cetintepe, Mustafa Necmi Ilhan   +5 more
wiley   +1 more source