Results 111 to 120 of about 111,907 (307)

Does curcumin or metformin attenuate oxidative stress and diabetic nephropathy in rats? [PDF]

, 2019
Background: Since the importance of oxidative stress in the development of diabetic nephropathy (DN) has previously been established, the therapeutic effects of various natural antioxidant agents or synthetic drugs have so far been investigated ...
Mohammad Taghi Goodarzi, Soheila Asadi, Mohammad Hashemnia, Jamshid Karimi, Iraj Khodadadi   +4 more
core   +1 more source

Impact of severe periodontitis and diabetes mellitus on recurrent cardiovascular outcomes

Journal of Periodontology, EarlyView.
Abstract Background This post hoc analysis of the Periodontitis and Coronary Heart Disease study (ClinicalTrials.gov Identifier: NCT01045070) aimed to determine the association between diabetes and recurrent cardiovascular events (CVEs) in patients with cardiovascular disease (CVD) and severe periodontitis.
Stefan Reichert, Axel Schlitt, Selina Rehm, Susanne Schulz   +3 more
wiley   +1 more source

Prevalence and risk factors of diabetic nephropathy among type 2 diabetes patients in family medicine clinic AFHSR Khamis Mushait

Journal of Family Medicine and Primary Care
Background: Diabetic nephropathy is a frequent complication of diabetes mellitus, affecting a considerable proportion of patients. Despite confirmed rising prevalence worldwide, little is known about its epidemiology in Saudi Arabia or its connection to ...
Saeed Mohammed Al-Shahrani, Bandar Mohammed Shaher, Yahya Mohammed Alragea, Fatima Mohammad Ali Alqahtani, Amjad Saeed Mansour Binghamiah, Mansour Ali Mansour Alqahtani, Saad Abdullah Mufrrih   +6 more
doaj   +1 more source

Role of alteration in Treg/Th17 cells’ balance in nephropathic patients with Type 2 diabetes mellitus

Electronic Physician, 2015
Introduction: In type 2 diabetes mellitus, the adaptive immune system drives systemic inflammation, promoting insulin resistance and related complications, such as diabetic nephropathy.
Sameh Abouzeid, Nevine Sherif
doaj   +1 more source

Erk5 Mediates TGFβ1-induced Loss of Phenotype and Function in Human Podocytes

, 2014
Diabetic nephropathy is one of the most common causes of renal impairment. Podocytes are specialised cells integral to normal kidney physiology, however in diabetes injury occurs leading to compromised function which is a critical factor in the ...
Irbaz I. Badshah, Irbaz Isaac Badshah, Deborah L. Baines, Dockrell, ME, Baines, DL, Mark Edward Dockrell, Mark E. Dockrell, Deborah L Baines, Badshah, II   +8 more
core   +1 more source

Association between periodontitis and oral health–related quality of life in patients with systemic conditions: A meta‐analysis

Journal of Periodontology, EarlyView.
Abstract Background The objective of this systematic review is to evaluate whether periodontitis is associated with impaired oral health–related quality of life (OHRQoL) in adults with systemic conditions. Methods Five databases were searched to identify observational studies that tested the association between periodontitis (diagnosed by clinical ...
Rafael Vargas Bortolaso, Catiusse Crestani Del' Agnese, Leandro Machado Oliveira, Patricia A. Miguez, Fabricio Batistin Zanatta, Raquel Pippi Antoniazzi   +5 more
wiley   +1 more source

Diabetic nephropathy – complications and treatment

, 2014
Andy KH Lim1–3 1Department of Nephrology, Monash Medical Center, Monash Health, 2Department of General Medicine, Dandenong Hospital, Monash Health, 3Department of Medicine, Monash University, Clayton, VIC, Australia Abstract: Diabetic nephropathy ...
Lim AK
core  

Therapeutic approaches to slowing the progression of diabetic nephropathy – is less best?

, 2013
Objective: Angiotensin II receptor blockers (ARBs) and angiotensin-converting enzyme (ACE) inhibitors are known to reduce proteinuria and have been the first-line agents in the management of diabetic nephropathy for the past 20 years.
Chelsea Mannebach, Eva Vivian
core   +1 more source

Lysosome Evanescence Mediates Autophagic Flux Impairment in Glucose Imbalanced Environments

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Schwann cells (SCs) support axonal function and promote nerve regeneration. This study investigated how various glucose concentrations influence SC viability, oxidative stress, and autophagy, which contribute to diabetic neuropathy. RSC96 SCs were cultured under five glucose conditions (0, 2.5, 5.5, 50, or 100 mM) for 24, 48, and 72 h.
Yuan‐Chen Cheng, Ling‐Li Chang, Hung‐Chen Wang, Wei‐Chun Hung, Chia‐Hua Hsieh, Yi‐Hsuan Wang, Kuang‐I Cheng   +6 more
wiley   +1 more source

METTL14 Ameliorates Mitochondrial Dysfunction and Autophagy in Lens Epithelial Cells of Diabetic Cataracts via m6A Modification of RPL3

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Diabetic cataracts are a leading cause of blindness, with lens epithelial cells (LECs) exhibiting mitochondrial dysfunction and autophagy inhibition under high glucose (HG) conditions. Methyltransferase‐like 14 (METTL14), an RNA methyltransferase, regulates N6‐methyladenosine (m6A) RNA modification; however, its role in modulating ...
Rui Li, Xue Wang, Wei Du, Qian Li, Hong‐Ping Cui   +4 more
wiley   +1 more source