Results 111 to 120 of about 753,615 (353)
Lean ZSF1 rats in basic research on heart failure with preserved ejection fraction
ESC Heart Failure, Volume 12, Issue 2, Page 1474-1478, April 2025.Abstract Aims ZSF1 obese rats harbouring two mutant leptin receptor alleles (Leprcp and Leprfa) develop metabolic syndrome and heart failure with preserved ejection fraction (HFpEF), making them a widely used animal model in cardiometabolic research.
Petra Büttner +10 more
wiley +1 more source
Hyperoside ameliorates diabetic nephropathy induced by STZ via targeting the miR-499–5p/APC axis
Journal of Pharmacological Sciences, 2021 Diabetic nephropathy is a serious complication of diabetes. Hyperoside has been widely reported to ameliorate diabetes-associated disease. The current study is designed to explore the mechanism of hyperoside in diabetic nephropathy. In the present study,
Jingbo Zhou +5 more
doaj
Metabolic and Endocrine Aspects of Diabetic Nephropathy [PDF]
, 1960 Nahed El Mahallawy +3 more
openalex +1 more source
Anti-TGF-β1 Antibody Therapy in Patients with Diabetic Nephropathy.
Journal of the American Society of Nephrology, 2017 TGF-β has been implicated as a major pathogenic factor in diabetic nephropathy. This randomized, double-blind, phase 2 study assessed whether modulating TGF-β1 activity with a TGF-β1-specific, humanized, neutralizing monoclonal antibody (TGF-β1 mAb) is ...
J. Voelker +11 more
semanticscholar +1 more source
Dapagliflozin alleviates high‐fat‐induced obesity cardiomyopathy by inhibiting ferroptosis
ESC Heart Failure, Volume 12, Issue 2, Page 1358-1373, April 2025.Abstract Aim: Dapagliflozin (Dapa) is a novel hypoglycaemic agent with multiple cardiovascular protective effects, and it is widely used in treatment of heart failure patients, but whether it can improve obese phenotype of heart failure and its mechanism is still unclear.
Di Chen +7 more
wiley +1 more source
Electronic Physician, 2015 Introduction: In type 2 diabetes mellitus, the adaptive immune system drives systemic inflammation, promoting insulin resistance and related complications, such as diabetic nephropathy.
Sameh Abouzeid, Nevine Sherif
doaj +1 more source
ESC Heart Failure, EarlyView.Abstract Aims Information about current use of finerenone in patients with heart failure (HF) finerenone in clinical practice is scarce, and its effectiveness in clinical practice in patients is scarce. We aim to assess both the baseline clinical profile and prognostic role of finerenone in patients with HF, irrespective of ejection fraction.
Gonzalo Luis Alonso Salinas +32 more
wiley +1 more source
Saudi Journal of Kidney Diseases and Transplantation, 2008 Diabetic nephropathy is found to be significantly associated with diabetic retino-pathy and coronary artery disease. Few studies have also shown an association between diabetic nephropathy and neuropathy, and peripheral vascular disease.
Chandy Anila +3 more
doaj
BMC Nephrology, 2019 Background Diabetic nephropathy is a global common cause of chronic kidney disease and end-stage renal disease. A lot of research has been conducted in biomedical sciences, which has enhanced understanding of the pathophysiology of diabetic nephropathy ...
Eduardo De la Cruz-Cano +7 more
doaj +1 more source
Oxidative Stress in Diabetic Nephropathy with Early Chronic Kidney Disease
Journal of Diabetes Research, 2016 The increase in the prevalence of diabetes mellitus (DM) and the secondary kidney damage produces diabetic nephropathy (DN). Early nephropathy is defined as the presence of microalbuminuria (30–300 mg/day), including normal glomerular filtration rate ...
A. Miranda-Díaz +3 more
semanticscholar +1 more source