Results 141 to 150 of about 331,620 (273)

Mechanistic Evaluation of Luteolin in Wound Healing of Diabetic Foot Ulcer via Nrf2 Signaling

open access: yesPhytotherapy Research, EarlyView.
Proposed mechanism by which Luteolin (LU) promotes diabetic foot ulcer healing. LU attenuates hyperglycemia‐induced oxidative stress and lipid peroxidation, improves endothelial cell viability, and suppresses ferroptosis through Nrf2‐dependent antioxidant signaling, thereby accelerating angiogenesis and wound repair. ABSTRACT Diabetic foot ulcers (DFUs)
Muhammed Yusuf   +2 more
wiley   +1 more source

Age‐related clinical heterogeneity and peripheral T cell profile alterations in primary Sjögren's disease: A retrospective study of 5778 patients

open access: yesRheumatology &Autoimmunity, EarlyView.
This large‐scale retrospective study of 5778 primary Sjögren's disease (SjD) patients, stratified by diagnostic age, defines a distinct clinical and immunological profile for early‐diagnosed (<45 years) disease. We identified early diagnosis as an independent risk factor for hypergammaglobulinemia and interstitial lung disease, underpinned by a ...
Yuan Ning   +7 more
wiley   +1 more source

Syndromic Mitochondrial Optic Neuropathies

open access: yes, 2012
In some of the hereditary optic neuropathies, optic nerve dysfunction is typically isolated. In others, various neurologic and systemic abnormalities are regularly observed.IC-E2dii5-other-mitochondrial ...
Nancy J. Newman, MD
core  

Driving Drugs Deeper: Force‐Driven Microneedle Systems for Active Therapy and Their Road Towards Clinical Implementation

open access: yesSmall, EarlyView.
Force‐driven microneedles are presented as active therapeutic microdevices that overcome the diffusion limits of conventional patches. By integrating gas generation, magnetic actuation, cavitation, or iontophoresis, these systems drive payloads deeper into tissue, enabling faster, more controlled delivery and highlighting key design principles and ...
Majed Amini   +3 more
wiley   +1 more source

Sensory profile of cats with potential pain‐related diabetic neuropathy

open access: yesVeterinary Record, EarlyView.
Abstract Background Diabetes mellitus (DM) can cause peripheral neuropathy. This study aimed to evaluate sensory function by measuring the mechanical nociceptive thresholds (MNT) and diffuse noxious inhibitory control (DNIC) of cats with diabetes mellitus (DMcats).
Hélène L. M. Ruel   +4 more
wiley   +1 more source

Respiratory Variability during Exercise: Associations with Motor Severity in Parkinson's Disease

open access: yes
Movement Disorders Clinical Practice, EarlyView.
Marcela S. Araújo   +7 more
wiley   +1 more source

Biomarkers to predict outcomes in diabetic foot ulcers

open access: yesVIEW, EarlyView.
Studies attempting to predict the healing outcome of diabetic foot ulcers (DFUs) have investigated various biological materials and recovered molecules that may aid in discriminating wounds that will heal and those that will not heal. This graphical abstract captures the commonly studied classes of biomarkers in the context of DFUs.
Julie Okiro   +6 more
wiley   +1 more source

Gut microbiota dysbiosis in the inflammatory pathogenesis of diabetic retinopathy

open access: yesVIEW, EarlyView.
This graphical abstract illustrates how gut dysbiosis drives diabetic retinopathy through the gut‐retina axis, a process unfolding in three interconnected stages. First, in the gut, a decrease in beneficial bacteria and an increase in pro‐inflammatory taxa compromise the intestinal barrier, causing a “leaky gut” that allows LPS to translocate into the ...
Junyan Hu, Jingxiang Zhong
wiley   +1 more source

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