Results 51 to 60 of about 447,312 (181)

Exploratory Evidence of a Gene–Smoking Interaction Involving MTR rs1805087 in Type 2 Diabetes Mellitus

ELECTROPHORESIS, EarlyView.
The graphical abstract illustrates how smoking interacts with an MTR rs1805087 gene variant to promote insulin resistance and β‐cell dysfunction through alterations in the folate cycle. PCR–RFLP genotyping and machine‐learning analysis support an exploratory assessment linking these combined factors to increased Type 2 diabetes risk in susceptible ...
João Pedro Costa Roriz, Leandro Prado Assunção, Nayane Soares de Lima, Diolina Gonçalves da Silva, Rodrigo da Silva Santos, Angela Adamski da Silva Reis   +5 more
wiley   +1 more source

Diabetic polyneuropathy, sensory neurons, nuclear structure and spliceosome alterations: a role for CWC22

Disease Models & Mechanisms, 2017
Unique deficits in the function of adult sensory neurons as part of their early neurodegeneration might account for progressive polyneuropathy during chronic diabetes mellitus.
Masaki Kobayashi, Ambika Chandrasekhar, Chu Cheng, Jose A. Martinez, Hilarie Ng, Cristiane de la Hoz, Douglas W. Zochodne   +6 more
doaj   +1 more source

Tolerability of Adjuvant Nivolumab in Esophageal or Gastroesophageal Junction Cancer: A Real‐World Study

International Journal of Cancer, EarlyView.
ABSTRACT Adjuvant nivolumab is approved for esophageal or gastroesophageal junction cancer after neoadjuvant chemoradiotherapy and resection. In the CheckMate‐577 trial, Grade 3–5 nivolumab‐related adverse events (AEs) occurred in 5% of patients, with early discontinuation due to toxicity in 9%. However, real‐world data on immunotherapy‐related adverse
Michelle Koops van ’t Jagt, Anniek Strijdhorst, Tamara Jessica Huizer, Esther Albertien Kleibeuker, Sarah Derks, Bianca Mostert, Hanneke van Laarhoven, Jacco Juri de Haan   +7 more
wiley   +1 more source

Somatic neuropathy is an independent predictor of all- and diabetes-related mortality in type 2 diabetic patients: a population-based 5-year follow-up study (KCIS No. 29)

, 2014
Background and purpose: To investigate the relationships of diabetic neuropathy to all-cause and diabetes-related mortality in patients with type 2 diabetes after controlling for significant correlates.
Hsu, W. -C.;Chiu, S. Y. -H.;Yen, A. M. -F.;Chen, L. -S.;Fann, C. -Y.;Liao, C. -S.;Chen, H. -H., 陳秀熙   +1 more
core   +1 more source

Sustainable Effects of Human Dental Pulp Stem Cell Transplantation on Diabetic Polyneuropathy in Streptozotocine-Induced Type 1 Diabetes Model Mice

Cells, 2021
Dental pulp stem cells (DPSCs) are suitable for use in regenerative medicine. Cryopreserved human DPSCs (hDPSCs) ameliorate diabetic polyneuropathy, and the effects of hDPSC transplantation are related to VEGF and NGF secretion.
Masaki Hata, Maiko Omi, Yasuko Kobayashi, Nobuhisa Nakamura, Megumi Miyabe, Mizuho Ito, Tasuku Ohno, Yuka Imanishi, Tatsuhito Himeno, Hideki Kamiya, Jiro Nakamura, Hitoshi Miyachi, Shogo Ozawa, Ken Miyazawa, Akio Mitani, Toru Nagao, Shigemi Goto, Jun Takebe, Tatsuaki Matsubara, Keiko Naruse   +19 more
doaj   +1 more source

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

The sensitivity of electromyoneurography in the diagnosis of diabetic polyneuropathy

, 2011
Diabetic polyneuropathy is a complex set of clinical syndromes, which deplete various regions of the nervous system. The process leading to diabetic neuropathy is multi-factorial. Its symptoms are paresthesia, dysesthesia and pain.
Miroslav Ilin, Zita Jovin, Milan Cvijanovic, Sofija Banic-Horvat, Petar Slankamenac   +4 more
core   +1 more source

Prevalence and Associations of Abnormal Levels of Vitamin B6 in People with Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background In people with Parkinson's disease, abnormal levels of vitamin B6 may be associated with polyneuropathy and epileptic seizures, including medication‐refractory status epilepticus. Objectives To estimate the prevalence and explore associations of abnormal levels of vitamin B6 in people with Parkinson's disease.
Karlo J. Lizarraga, Lu Wang, Hannah Mesmer, Nami Shah, William Barbosa, Eric Logigian, Michael P. McDermott, Anthony E. Lang   +7 more
wiley   +1 more source

Blink reflex alterations in diabetic patients with or without polyneuropathy

, 2008
The main aim of this study is to evaluate the role of blink reflex for early diagnosis of cranial neuropathy in diabetic patients with or without polneuropathy.
Guney, Figen, Demir, Orhan, Gonen, Mustafa Sait   +2 more
core   +1 more source

Inborn errors of immunity in children with neuroinflammation

Developmental Medicine &Child Neurology, EarlyView.
Abstract Inborn errors of immunity (IEIs), an expanding group of monogenic disorders with diverse clinical manifestations, are increasingly recognized to include neuroinflammatory disease. Examples of diseases included under this umbrella are Aicardi–Goutières syndrome, deficiency of adenosine deaminase 2, familial haemophagocytic lymphohistiocytosis ...
Eppie M Yiu, Dilan Dissanayake, Jessie Cunningham, Helen Branson, Ori Scott, E Ann Yeh   +5 more
wiley   +1 more source