Results 111 to 120 of about 835,910 (363)

The NLRP3 inflammasome pathway contributes to chronic inflammation in experimental autoimmune uveitis

Animal Models and Experimental Medicine, EarlyView.
The present study investigates the role of the NLRP3 inflammasome in the chronicity of ocular inflammation in uveitis using the experimental autoimmune uveitis (EAU) model. Whole eyes collected from EAU mice, 12 weeks post induction, were sectioned and subjected to immunohistochemistry. The confocal images from these sections were then assessed for the
Avik Shome, Ilva D. Rupenthal, Rachael L. Niederer, Odunayo O. Mugisho   +3 more
wiley   +1 more source

Endothelial Dysfunction in Diabetic Retinopathy

Frontiers in Endocrinology, 2020
Diabetic retinopathy (DR) is a diabetic complication which affects retinal function and results in severe loss of vision and relevant retinal diseases. Retinal vascular dysfunction caused by multifactors, such as advanced glycosylation end products and ...
Fu Gui, Zhipeng You, Shuhua Fu, Hongxi Wu, Yulan Zhang   +4 more
semanticscholar   +1 more source

Classification of Human Retinal Microaneurysms Using Adaptive Optics Scanning Light Ophthalmoscope Fluorescein Angiography [PDF]

, 2014
Purpose. Microaneurysms (MAs) are considered a hallmark of retinal vascular disease, yet what little is known about them is mostly based upon histology, not clinical observation.
Carroll, Joseph, Chui, Toco Y.P., Cooper, Robert F., Dubow, Michael, Dubra, Alfredo, Gan, Alexander, Gentile, Ronald C., Hendrix, Vernon, Pinhas, Alexander, Rosen, Richard B., Shah, Nishit, Sulai, Yusufu N., Walsh, Joseph B., Weitz, Rishard   +13 more
core   +2 more sources

Adiponectin may be used as a marker in prediction of diabetic retinopathy patients

Iraq Medical Journal, 2018
Objective To investigate the validity of serum adiponectin to differentiate diabetic retinopathy and to evaluate the relation between the tumor necrosis factor-alpha (TNFα) and adiponectin in this disease.
Zahra Saad Hatef, Shaymaa Zahraw Nada, Ali Mansoor Jasim   +2 more
doaj  

Proliferative diabetic retinopathy is associated with microalbuminuria in patients with type 2 diabetes

Brazilian Journal of Medical and Biological Research, 2006
Diabetic retinopathy is one of the leading causes of blindness in working-age individuals. Diabetic patients with proteinuria or those on dialysis usually present severe forms of diabetic retinopathy, but the association of diabetic retinopathy with ...
M.C. Boelter, J.L. Gross, L.H. Canani, L.A. Costa, H.R. Lisboa, G.S. Três, J. Lavinsky, M.J. Azevedo   +7 more
doaj   +1 more source

Neutrophil‐to‐lymphocyte and monocyte‐to‐lymphocyte ratios as inflammatory markers in the assessment of glycemic status in diabetic patients of Asir region

Animal Models and Experimental Medicine, EarlyView.
Neutrophil‐to‐lymphocyte ratio (NLR) and monocyte‐to‐lymphocyte ratio (MLR) were investigated as potential markers. A total of 3545 subjects were included in the analysis retrospectively. Adult men and women with impaired glucose metabolism were assessed. NLR and MLR may help assess inflammation in individuals with impaired glucose metabolism. Abstract
Ayed A. Dera, Abeer Abdullah Alghamdi, Mesfer Al‐Shahrani, Reem M. Al‐Gahtani, Bashayer Saad Alghamdi, Gaffar Sarwar Zaman, Mohammed Abdul Rasheed, Hassan Al‐Shehri, Lana Al‐qhtani, Syed Parween Ali, Umme Hani, Talha Bin Emran   +11 more
wiley   +1 more source

A broad study of machine learning and deep learning techniques for diabetic retinopathy based on feature extraction, detection and classification

Measurement: Sensors, 2023
Diabetic Retinopathy (DR) is a micro vasculardisorder that affects the eyes and is a long term effectofDiabetesmellitus. The likelihood to develop diabetic retinopathy is directly proportional to the age and duration of the diabetes, as well as increase ...
Krishnan Sangeetha, K. Valarmathi, T. Kalaichelvi, S. Subburaj   +3 more
doaj  

Vascular and Cardiac Target Organ Damage in Type 2 Diabetics With and Without Diabetic Retinopathy

Archives of Clinical and Experimental Surgery, 2013
Objective: In this study, we sought to assess the differences in cardiac and vascular end-organ damage in type 2 diabetics, with and without diabetic retinopathy. Methods: A cross-sectional study of 131 diabetic patients (44 with diabetic retinopathy and
Francisco Leon-Garrigosa, Jessica M Schrieber, J. Javier Servat, Luis Garcia-Ortiz, Jose Ignacio Recio-Rodriguez, Ma Carmen Patino-Alonso, Cristina Agudo-Conde, Emiliano Rodriguez Sanchez, Manuel Angel Gomez-Marcos   +8 more
doaj   +1 more source

Nanostructured drug delivery systems for posterior segment eye diseases: Strategies to defy ocular barriers

BMEMat, EarlyView.
Efficient drug delivery to the posterior segment of the eye has long been a challenging issue due to the complex ocular barriers. The review focuses on the promise held by nanoplatforms for barrier penetration and the key mechanisms involved, also highlighting their advantages in achieving efficient drug delivery and superior treatment of PSEDs ...
Yifan Shen, Ying Yao, Yan Zhang, Xinyu Shi, Ling Bai, Yang Zhong, Yan Zhang, Kun Zhang   +7 more
wiley   +1 more source

Long noncoding RNA MALAT1 and Regulation of the Antioxidant Defense System in Diabetic Retinopathy.

Diabetes, 2020
Retina experiences increased oxidative stress in diabetes, and the transcriptional activity of Nrf2, critical in regulating many antioxidant genes, is decreased. Nuclear movement-transcriptional activity of Nrf2 is mediated by its intracellular inhibitor
R. Radhakrishnan, R. Kowluru
semanticscholar   +1 more source