Results 131 to 140 of about 203,197 (289)

Ex Vivo Evaluation of Poly(Solketal Acrylate) Nanoparticles for Intravitreal Drug Delivery to the Posterior Eye Segment

Macromolecular Rapid Communications, EarlyView.
Nile Red‐loaded poly(solketal acrylate) nanoparticles enable fluorescence tracking and exhibit nontoxic profiles in retinal cells. Enhanced cellular uptake and deep retinal penetration after intravitreal injection highlight their excellent potential for targeted ocular drug delivery to the posterior segment of the eye.
Yasaman Pourdakheli Hamedani, José Hurst, Malte Ritter, Philipp Weingarten, Julia Skokowa, Sven Schnichels, Friederike Adams   +6 more
wiley   +1 more source

Diabetic Peripheral Neuropathy: Molecular Staging, Risk Factors, Therapeutics, and Emerging Trends

Med Research, EarlyView.
The heterogeneous landscape of DPN can be unified through a tripartite pathogenic model encompassing progressive stages of metabolic dysregulation, chronic inflammation, and overt neuronal damage. Within this framework, six clinical subtypes were identified, namely, hyperglycemia‐driven, dyslipidemia‐driven, inflammation‐driven, dysvascularity‐driven ...
Xiaofeng Dai, Mingze Tang
wiley   +1 more source

Correlation Between Gut Microbiota, Metabolites, and Diabetic Complications: A Two‐Sample Mendelian Randomization Study

Medicine Advances, EarlyView.
Fang et al. demonstrate a significant causal relationship among gut microbiota, gut metabolites, and diabetic complications, highlighting a biological link underlying mechanisms of diabetic vascular diseases. These findings provide important implications for future therapeutic strategy and risk prediction.
Jiaxi Fang, Leilei Zhai, Chan Huang, Liqin Li, Yong Wang, Jiaojiao Fan, Wei Zhou   +6 more
wiley   +1 more source

Diabetic Retinopathy: Pathogenesis, Clinical Features and the Role of Physical Activity in Prevention and Management

Quality in Sport
Background    Diabetic retinopathy (DR) is a vision-threatening microvascular complication of diabetes mellitus that affects the retina and is classified into non-proliferative (NDPR) and proliferative (PDR) forms with diabetic macular edema (DME ...
Wiktoria Marzec, Wiktoria Boral, Marek Dróżdż, Jan Puliński, Julia Linke, Michał Napierała, Szymon Stupnicki, Agnieszka Bajkacz, Bartosz Olkowski, Alicja Maczkowska   +9 more
doaj   +1 more source

Alcohol: another risk factor for diabetic retinopathy? [PDF]

, 1984
Clarke, B. F., McCulloch, D K, Prescott, Robin J, Young, R.J   +3 more
core   +1 more source

Association of Glucagon‐Like Peptide‐1 Receptor Agonists With Cancer Risk in Older Adults With Type 2 Diabetes

Obesity, EarlyView.
ABSTRACT Objective The real‐world evidence on the association between glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) and cancer risk remains limited and mixed. Methods In 2013–2020 national Medicare claims data, we included cancer‐naïve patients with type 2 diabetes (T2D). We identified those who initiated GLP‐1 RA, sodium‐glucose cotransporter 2
Ying Lu, Hao Dai, Huilin Tang, William T. Donahoo, Thomas J. George, Ramon C. Sun, Sizun Jiang, Aik Choon Tan, Yi Guo, Jonathan D. Licht, John M. Allen, Kelvin P. Lee, Jingchuan Guo, Jiang Bian   +13 more
wiley   +1 more source

Evaluating the Evolving Real‐World Adverse Events of GLP‐1RAs Using FDA Adverse Event Reporting System (FAERS)

Obesity, EarlyView.
Web portal for interrogating Adverse Events of GLP‐1 RA in diabetes vs weight control/obesity. ABSTRACT Objective This study aimed to assess the spectrum and frequency of adverse events (AEs) linked to glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) using the US FDA Adverse Event Reporting System (FAERS).
David Stone, Mary Playdon, Stephen D. Hursting, Aik Choon Tan   +3 more
wiley   +1 more source

Circadian Biorhythms of Stress-limiting Hormones in Patients with Diabetic Retinopathy and Sarcopenic Obesity

Oftalʹmologiâ
The development of diabetic retinopathy is associated with the levels of melatonin, dehydroepiandrosterone and some other stress-limiting hormones, however, the circadian biorhythms of the latter were practically not analyzed in patients with diabetic ...
A. E. Kopylov, O. L. Fabrikantov, N. M. Agarkov, D. R. Shmarova   +3 more
doaj   +1 more source

The transformative potential of artificial intelligence in pediatric medicine: Current applications, methodological challenges, and future directions

Pediatric Investigation, EarlyView.
Artificial intelligence (AI) offers transformative potential for paediatric diagnosis and treatment, yet implementation faces unique challenges, including data scarcity, algorithmic bias, and children's developmental physiology. This review examines current applications and charts a path toward transparent, equitable, and trustworthy AI in child health.
Ruisong Wang, Xiaoman Ding, Wanyue Zhang, Tieliu Shi   +3 more
wiley   +1 more source

Audio‐guided exercise at home: Preliminary findings from a pilot study on physical activity for people with low vision

PM&R, EarlyView.
Abstract Background: Individuals with severe visual impairments frequently refrain from regular physical activity due to multiple barriers, including transportation difficulties, financial constraints, and limited availability of exercise programs tailored to their needs. These factors often contribute to a gradual decline in mobility and independence.
Luca Correale, Monica Schmid, Francesco Decortes, Luca Martinis, Giulia Liberali, Luca Bandirali, Gabriella Cusella, Cristina Montomoli   +7 more
wiley   +1 more source