Results 11 to 20 of about 1,286 (153)

Disruption of Hepatic Insulin Signaling Causes Phospholipid Dysregulation in Mice. [PDF]

FASEB J
Pan et al. demonstrate that disruption of hepatic insulin signaling by insulin receptor (IR) substrate (IRS1/2) deletion led to impaired PI3K‐AKT signaling, causing increased Foxo1 activation and TGF‐β1 expression, which dysregulated the expression of the key enzymes involving phospholipid biosynthesis and remodeling.
Pan Q, Pan M, Ai W, Yang W, Jiang W, Han X, Guo S.   +6 more
europepmc   +2 more sources

Understanding the dynamic nature of plant lipid anabolic and catabolic metabolism is key to sustainable oilseed engineering. [PDF]

New Phytol
Summary Plant‐derived oils are essential sources of reduced carbon and various fatty acid (FA) structures for food, biofuels, and the oleochemical industry. Despite extensive efforts, engineering mainstream oilseed crops to produce high levels of industrially valuable unusual FAs (UFAs) remains challenging.
Parchuri P, McGuire ST, Garneau MG, Barroga NAM, Bates PD.   +4 more
europepmc   +2 more sources

Design of high-monounsaturated fatty acid soybean seed oil using GmPDCTs knockout via a CRISPR-Cas9 system. [PDF]

Plant Biotechnol J, 2023
Plant Biotechnology Journal, Volume 21, Issue 7, Page 1317-1319, July 2023.
Li H, Zhou R, Liu P, Yang M, Xin D, Liu C, Zhang Z, Wu X, Chen Q, Zhao Y.   +9 more
europepmc   +2 more sources

Protein interactomes for plant lipid biosynthesis and their biotechnological applications

Plant Biotechnology Journal, Volume 21, Issue 9, Page 1734-1744, September 2023., 2023
Summary Plant lipids have essential biological roles in plant development and stress responses through their functions in cell membrane formation, energy storage and signalling. Vegetable oil, which is composed mainly of the storage lipid triacylglycerol, also has important applications in food, biofuel and oleochemical industries.
Yang Xu, Stacy D. Singer, Guanqun Chen
wiley   +1 more source

Pathophysiology of type 2 diabetes and the impact of altered metabolic interorgan crosstalk

The FEBS Journal, Volume 290, Issue 3, Page 620-648, February 2023., 2023
Type 2 diabetes (T2D) is a complex disease involving several tissues. Here, we explore how metabolites contribute to signaling between tissues (interorgan crosstalk). Metabolite signaling can be viewed as additional option to the well‐known hormones and organokines contributing to interorgan crosstalk.
Jose Marcos Sanches, Li Na Zhao, Albert Salehi, Claes B. Wollheim, Philipp Kaldis   +4 more
wiley   +1 more source

Pyruvate transporter BnaBASS2 impacts seed oil accumulation in Brassica napus

Plant Biotechnology Journal, Volume 20, Issue 12, Page 2406-2417, December 2022., 2022
Summary Bile acid: sodium symporter family protein 2 (BASS2) is a sodium‐dependent pyruvate transporter, which transports pyruvate from cytosol into plastid in plants. In this study, we investigated the function of chloroplast envelope membrane‐localized BnaBASS2 in seed metabolism and seed oil accumulation of Brassica napus (B. napus).
Shan Tang, Ning Guo, Qingqing Tang, Fei Peng, Yunhao Liu, Hui Xia, Shaoping Lu, Liang Guo   +7 more
wiley   +1 more source

Transcriptomic Analysis and Histological Alteration of Black Sea Bream (Acanthopagrus schlegelii) Liver Fed Different Protein/Energy Ratio Diets

Aquaculture Nutrition, Volume 2022, Issue 1, 2022., 2022
To systematically investigate the effects of different protein/energy (P/E) ratio diets on the microstructure and metabolic response of black sea bream liver, fish (initial weight 11.20 ± 0.20 g) were fed three isoenergetic (20.9 kJ/g) diets with varying protein/lipid levels (LR, 28.8% protein/26.3% lipid; MR, 37.5% protein/20.9% lipid; and HR, 42.8 ...
Lei Wang, Gladstone Sagada, Bin Wang, Bingying Xu, Lu Zhen, Yunzhi Yan, Qingjun Shao, Mahmoud Dawood   +7 more
wiley   +1 more source

Camelina sativa phosphatidylcholine:diacylglycerol cholinephosphotransferase‐catalyzed interconversion does not discriminate between substrates

Lipids, Volume 56, Issue 6, Page 591-602, November 2021., 2021
Abstract Phosphatidylcholine:diacylglycerol cholinephosphotransferases (PDCT) regulate the fatty acid composition of seed oil (triacylglycerol, TAG) by interconversion of diacylglycerols (DAG) and phosphatidylcholine (PtdCho). PtdCho is the substrate for polyunsaturated fatty acid biosynthesis, as well as for a number of unusual fatty acids.
Kamil Demski, Simon Jeppson, Sten Stymne, Ida Lager   +3 more
wiley   +1 more source

DELLA proteins BnaA6.RGA and BnaC7.RGA negatively regulate fatty acid biosynthesis by interacting with BnaLEC1s in Brassica napus

Plant Biotechnology Journal, Volume 19, Issue 10, Page 2011-2026, October 2021., 2021
Summary Seed oil content (SOC) and fatty acid (FA) composition determine the quality and economic value of rapeseed (Brassica napus). Little is known about the role of gibberellic acid (GA) in regulating FA biosynthesis in B. napus. Here, we discovered that four BnaRGAs (B.
Guanbo Yan, Pugang Yu, Xia Tian, Liang Guo, Jinxing Tu, Jinxiong Shen, Bin Yi, Tingdong Fu, Jing Wen, Kede Liu, Chaozhi Ma, Cheng Dai   +11 more
wiley   +1 more source

Accumulation and deposition of triacylglycerols in the starchy endosperm of wheat grain. [PDF]

J Cereal Sci, 2021
A combination of lipidomics, transcriptomics and bioimaging has been used to study triacylglycerol synthesis and deposition in the developing starchy endosperm of wheat.
González-Thuillier I, Pellny TK, Tosi P, Mitchell RAC, Haslam R, Shewry PR.   +5 more
europepmc   +2 more sources